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1

Effect of botulinum toxin [BTX] on the chemical coding of nerve fibres supplying the canine urinary bladder

100%
Lew S., Bossowska A., Radziszewski P., Majewski M., Kwiatkowska M., Kuleta Z.
Bulletin of the Veterinary Institute in Puławy
|
2010
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tom 54
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nr 1
69-74
The objective of this study was to investigate the distribution and chemical coding patterns of nerve fibres supplying the canine urinary bladder before and after botulinum toxin (BTX) injection. The experimental material comprised six bitches. The injection of the BTX into the urinary bladder wall in dogs clearly altered the bladder's innervation pattern, indicating that BTX affects the components of both the sensory and parasympathetic nervous systems, and that degenerative changes are accompanied by restorative processes.
2
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Conantokin G-induced changes in the chemical coding of dorsal root ganglion neurons supplying the porcine urinary bladder

84%
Bossowska A., Majewski M.
Polish Journal of Veterinary Sciences
|
2012
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tom 15
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nr 1
Conantokin G (CTG), isolated from the venom of the marine cone snail Conus geographus, is an antagonist of N-methyl-d-aspartate receptors (NMDARs), the activation of which, especially those located on the central afferent terminals and dorsal horn neurons, leads to hypersensitivity and pain. Thus, CTG blocking of NMDARs, has an antinociceptive effect, particularly in the case of neurogenic pain treatment. As many urinary bladder disorders are caused by hyperactivity of sensory bladder innervation, it seems useful to estimate the influence of CTG on the plasticity of sensory neurons supplying the organ. Retrograde tracer Fast Blue (FB) was injected into the urinary bladder wall of six juvenile female pigs. Three weeks later, intramural bladder injections of CTG (120 μg per animal) were carried out in all animals. After a week, dorsal root ganglia of interest were harvested from all animals and neurochemical characterization of FB+ neurons was performed using a routine double-immunofluorescence labeling technique on 10-μm-thick cryostat sections. CTG injections led to a significant decrease in the number of FB+ neurons containing substance P (SP), pituitary adenylate cyclase activating polypeptide (PACAP), somatostatin (SOM), calbindin (CB) and nitric oxide synthase (NOS) when compared with healthy animals (20% vs. 45%, 13% vs. 26%, 1.3% vs. 3%, 1.2 vs. 4% and 0.9% vs. 6% respectively) and to an increase in the number of cells immunolabelled for galanin (GAL, 39% vs. 6.5%). These data demonstrated that CTG changed the chemical coding of bladder sensory neurons, thus indicating that CTG could eventually be used in the therapy of selected neurogenic bladder illnesses.
3
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The influence of resiniferatoxin on the chemical coding of neurons in dorsal root ganglia supplying the urinary bladder in the female pig

84%
Bossowska A., Majewski M.
Polish Journal of Veterinary Sciences
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2012
|
tom 15
|
nr 1
Although resiniferatoxin (RTX) becomes more often used in experimental therapies of sensory system disorders, so far there is no data concerning the influence of RTX on the chemical coding of neurons in dorsal root ganglia (DRG) supplying the urinary bladder in the pig, an animal species considered as a reliable animal model for investigation dealing with human lower urinary tract disorders. Retrograde tracer Fast Blue (FB) was injected into the wall of the right half of the urinary bladder in six juvenile female pigs, and three weeks later, bladder instillation of RTX (500 nmol per animal) was carried out in all the animals. After a week, DRGs were harvested from all the pigs and the neurochemical characterization of FB+ neurons was performed using routine single-immunofluorescence labeling technique on 10-μm-thick cryostat sections. RTX instillation resulted in a distinct decrease in the numbers of FB+ cells containing calcitonin gene-related peptide (CGRP), nitric oxide synthase (NOS), somatostatin (SOM) and calbindin (CB) when compared with those found in the healthy animals (18% vs. 36%, 1% vs. 6%, 0.8% vs. 4% and 0.5% vs. 3%, respectively), and an increase in the number of pituitary adenylate cyclase-activating polypeptide (PACAP)- and galanin (GAL)-immunoreactive (IR) nerve cells (51% vs. 26% and 47% vs. 6.5%). The results obtained suggest that RTX could be taken into consideration when the neuroactive agents are planned to be used in experimental therapies of selected neurogenic bladder illnesses.
4

The distribution and chemical coding of neurons in the celiac-superior mesenteric ganglion complex supplying the normal and inflamed ileum in the pig

84%
Kaleczyc J., Pidsudko Z., Franke-Radowiecka A., Sienkiewicz W., Majewski M., Lakomy M., Timmermans J. P.
Polish Journal of Veterinary Sciences
|
2004
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tom 07
|
nr 3
The present study investigated the chemical coding of neurons in the celiac-superior mesenteric ganglion complex supplying the normal (n = 4) and inflamed (n=4) ileum (chemically-in- duced inflammation) in juvenile pigs using retrograde tracing combined with immunohistochem- istry. Ileum-projecting neurons (IPN) were predominantly distributed in the left and right superior mesenteric pools of the ganglion. The majority of them were adrenergic (tyrosine hydroxylase-positive) and also contained neuropeptide Y, somatostatin or galanin. No clear-cut differences in the distribution and chemical coding of IPN were found between normal and inflamed pigs. However, in the inflamed group, the density of peptidergic, IPN-associated nerve fibres was higher than that found in the control group.
5

Distribution and chemical coding pattern of the cocaine- and amphetamine-regulated transcript (CART) immunoreactivity in the preoptic area of the pig

67%
Bogus-Nowakowska K., Robak A., Rowniak M., Wasilewska B., Najdzion J., Kolenkiewicz M., Zakowski W., Majewski M.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 4
6

Distribution and chemical coding of calretinin- and calbindin-expressing enteric neurons in the duodenum of the sheep

67%
Arciszewski M. B., Calka J., Wasowicz K., Majewski M.
Polish Journal of Veterinary Sciences
|
2009
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tom 12
|
nr 4
Recent decades has brought significant advances in our knowledge of the chemical coding and function of enteric neurons. Calcium ions are important second messenger involved in many aspects of neuron physiology. In the present study, we analyzed immunohistochemically the presence of calcium binding proteins (calretinin and calbindin) in various subpopulations of enteric neurons from the ovine duodenum. Ten percent of submucous neurons were immunoreactive (IR) to calretinin. The presence of calretinin was not detected in myenteric neurons. Calretinin-expressing nerve fibres were found in both myenteric and submucous ganglia, between the circular and longitudinal smooth muscle layers and in the lamina muscularis mucosae. Calretinin-IR submucous neurons did not exhibit the presence of SP, NPY and VIP. Co-localization of calretinin and serotonin was found only in a small number of submucous neurons. Calbindin was expressed in 35% of myenteric neurons and in 60% of submucous neurons. Nerve fibres containing calbindin were localized in myenteric and submucous ganglia where they frequently formed basket-like formations. Calbindin-positive nerve fibres emerging from myenteric ganglia ran between the circular and longitudinal smooth muscle layers. Immunoreactivity to calbindin was also visualized in the lamina muscularis mucosae, around mucosal glands and blood vessels. None of calbindin-IR myenteric neurons revealed immunoreactivity to SP, NPY, VIP and serotonin. Virtually all calbindin-expressing submucous neurons were SP-positive. In moderate numbers of submucous perikarya, co-incidence of calbindin and NPY, calbindin and VIP or calbindin and serotonin was observed. We conclude that in the ovine duodenum, the expression of calretinin and calbindin is species specific. Co-localization studies and distribution patterns indicate that in the duodenum of the sheep, calretinin and calbindin may be present in several functional subclasses of enteric neurons.
7

Distribution and chemical coding pattern of somatostatin immunoreactivity in the dorsal striatum of the guinea pig

67%
Wasilewska B., Robak A., Rowniak M., Bogus-Nowakowska K., Najdzion J., Zakowski W., Majewski M.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 4
8

Differences in the chemical coding of nerve fibres supplying major populations of neurons between the caudal mesenteric ganglion and anterior pelvic ganglion in the male pig

67%
Kaleczyc J., Sienkiewicz W., Klimczuk M., Czaja K., Lakomy M.
Folia Histochemica et Cytobiologica
|
2003
|
tom 41
|
nr 4
9

Analysis of the chemical coding of neurons in the intermediate thoracic ganglion of the pig

59%
NouriNezhad J., Wasowicz K., Bukowski R., Skobowiat C.
Polish Journal of Veterinary Sciences
|
2010
|
tom 13
|
nr 3
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