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Instability of hemispheric asymmetry in dyslexic children

100%

Koltuska B., Grabowska A.

Acta Neurobiologiae Experimentalis

1992

tom 52

nr 1

The neuroprotective effect of 2-oxoglutarate in the experimental ischemia of hippocampus

80%

Kovalenko T. N., Ushakova G. A., Osadchenko I., Skibo G. G., Pierzynowski S. G.

Journal of Physiology and Pharmacology

2011

tom 62

nr 2

In this study we investigated the potential neuroprotective effect of 2-oxoglutarate (2-OG) on the hippocampus in the transient vessel occlusion ischemia model in the Mongolian gerbil. The morphological and biochemical studies were performed at 7 days after occlusion of carotid arteries. The acute reduction of NeuN-positive neurons in the CA1 pyramidal layer of the hippocampus was accompanied by increased staining intensity for GFAP-positive astrocytes, indicative of glial reaction. The neuron death in the CA1 area coincided with a strong 2.4 fold decrease in the membrane forms of neuronal cell adhesion molecules and elevated levels of astrocyte-specific proteins (soluble GFAP to 2,6 times; filament GFAP to 1,5 times; calcium-binding protein S-100b to 1,6 times). Treatment with 2-oxoglutarate (2.28 g/l drinking water) for between 7 and 21 days attenuated the neuronal death and reactive astrogliosis in this model of experimental ischemia by 20-50%. Our results suggest that 2-OG may prevent the disturbances of neural cells that usually take place during ischemic pathology.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Journal of Physiology and Pharmacology

1 Grabowska A.

1 Koltuska B.

1 Kovalenko T. N.

1 Osadchenko I.

1 Pierzynowski S. G.

1 Skibo G. G.

1 Ushakova G. A.

1 2011

1 1992

Wyniki wyszukiwania

Instability of hemispheric asymmetry in dyslexic children

The neuroprotective effect of 2-oxoglutarate in the experimental ischemia of hippocampus