Wyniki wyszukiwania

1

Fractal description of cerebellum surface during fetal period

100%

Rybaczuk M., Kedzia A., Blaszczyk E.

Folia Morphologica

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1996

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tom 55

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nr 4

2

The tetraploidy of Purkinje cells in the cerebellum in reference to the problem of polyploidy

100%

Kowalska E., Marcinkowski T.

Folia Histochemica et Cytobiologica

|

1997

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tom 35

|

nr 2

3

Fractal analysis of adults cerebellum surface NMR observations

88%

Rybaczuk M., Kedzia A.

Folia Morphologica

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1996

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tom 55

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nr 4

4

An influence of lesions of the catecholaminergic cerebellar innervation on the harmaline-induced tremor in rats

75%

Wardas J., Kolasiewicz W., Kuter K., Berghauzen K., Nowak P., Mikolajun U., Zapala M., Ossowska K.

Acta Neurobiologiae Experimentalis

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2013

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tom 73

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nr 1

Recent studies have suggested a crucial role of the cerebellum in different forms of tremor. Abnormal synchronous activation of the glutamatergic olivo-cerebellar pathway and Purkinje cells results in the essential tremor in humans and the harmaline-induced tremor in animals. Moreover, an increased neuronal activity of the cerebellum has been found to contribute to the tremor in Parkinson’s disease (PD). Since the cerebellum receives dopaminergic and noradrenergic pathways arising from regions affected in PD, the aim of the present study was to examine a contribution of the cerebellar catecholaminergic innervation to the harmaline-induced tremor in rats. Rats were bilaterally injected into the cerebellar vermis (lobules 8–10) with 6-hydroxydopamine (6-OHDA) (8 μg/0.5 μl) either alone or this treatment was preceded by desipramine (15 mg/kg i.p.). Harmaline was administered at a dose of 7.5 mg/kg i.p. on the 9th post-operative day. Tremor of forelimbs was measured as a number of episodes. After completion of behavioural experiments rats were killed by decapitation and the levels of monoamines and their metabolites were measured by HPLC in lobules 1–3, 4–7 and 8–10 of the cerebellum. 6-OHDA injected alone decreased the noradrenaline level by ca. 40–80% in the cerebellum and enhanced the harmaline-induced tremor. When 6-OHDA administration was preceded by desipramine, it decreased dopaminergic transmission in some regions of the cerebellum but induced its compensatory activation in others. Finally no influence of the latter treatment on the tremor induced by harmaline was observed. The present study indicates that the noradrenergic innervation of the cerebellum plays an inhibitory role in the harmaline-induced tremor. The study was supported by the grant of the Ministry of Science and Higher Education No N N401 570638, and partly by Statutory Funds of the Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland.

5

Venous angioarchitecture of human cerebellum in fetal period

75%

Kedzia A., Kedzia W.

Folia Morphologica

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1996

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tom 55

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nr 4

6

The early development of the external germinal layer of the human embryonic cerebellum

75%

Janczewski M., Bruska M., Wozniak W.

Folia Morphologica

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1998

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tom 57

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nr 1

7

Effect of alkylating drugs on rat cerebellum

63%

Maslinska D.

Folia Histochemica et Cytobiologica

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1986

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tom 24

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nr 1

8

Arteries that supply the brain and the formation of circulus arteriosus cerebri in donkeys

63%

Ozgel O., Dursun N., Oto C.

Medycyna Weterynaryjna

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2007

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tom 63

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nr 12

1561-1563

The study investigated the anatomy of the arteries of the brain in seven donkeys following intravascular injection of colored latex via the a. vertebralis and a. carotis communis. Arterial blood washed the brain via the bilateral a. carotis interna and a. vertebralis and via the unpaired a. basilaris. A. carotis interna entered the cavum cranii at the level of sulcus pontocruralis, and ramified at the level of the corpus mamillare into a. cerebri rostralis and a. communicans caudalis. At the level intracranial entry, a. carotis interna gave rice to a. caroticobasillaris which was bilaterally present in 4 cases and unilaterally in 1 animal, a. caroticobasillaris, whereas the other branch was and a. constant a. intercarotica caudalis which was located at the level of sulcus pontocruralis. In one cadaver, a very slender a. intercarotica rostralis originated from a. carotis interna at the level of the origin of a. cerebri rostralis, and joined its counterpart vessel at the border between tuber cinereum and chiasma opticum. In all cases, a. ethmoidalis interna originated from a. cerebri rostralis. It was observed that a. cerebri rostralis dextra et sinistra fused directly into a. single median vessel named a. communicans rostralis.

9

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Spontaneous and evoked activities of interpositus nucleus neurons before and after lesion of the cerebellar cortex

63%

Tarnecki R., Morrison A. R., Rajkowski J., Sarna M. F., Zurawska I.

Acta Physiologica Polonica

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1987

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tom 38

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nr 4

10

Effect of sex and localization dependent differences of Na,K-ATPase properties in brain of rats

63%

Kolocayova B., Vrbjar N.

Journal of Physiology and Pharmacology

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2020

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tom 71

|

nr 2

11

New method of longitudinal spinal cord slice culture

63%

Koniusz S., Kawalec M., Sypecka J., Sarnowska S.

Acta Neurobiologiae Experimentalis

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2013

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tom 73

|

nr 1

Organotypic slice cultures were established as a model that own properties of both cell culture and animal model. The most often used slice culture is derived from hippocampus but depending on the part of brain affected with pathology, researchers established cultures from cerebellum, midbrain or striatum. Above mentioned models allowed the investigation of disorders resulting from e.g. ischemia, trauma or toxic injury. Besides the brain injury, numerous studies were focused on spinal cord pathology connected with demyelination, inflammation or injury. Here, we describe the development of an in vitro model of longitudinal spinal cord slice culture. Compared to cell (neuron-oligodendrocyte) co-cultures, organotypic slices retain tissue organization as well as cell-cell contacts and therefore more closely mimic the environment in vivo. We demonstrate the applicability of this approach for xenograft transplantation of oligodendrocyte precursor cells derived from rat brain and mesenchymal stem cells derived from human umbilical cord. Stem cells fate after transplantation was observed in two paradigms: after cell transplantation on the top of spinal cord slice cultures (SCC) or cocultivation of cell culture with SCC space separated for 24 h. We observed the different morphology and protein expression of stem cells derived from different sources. Moreover, the same stem cells co-cultured with slices derived from different part of brain (hippocampus or spinal cord) expressed other markers. The method of longitudinal spinal cord slices enables observation of long fibers trajectory, new connections and neurorepair mechanisms. Moreover, it provides a time-efficient and costeffective adjunct to cell lines or in vivo transplantation models for study spinal cord pathology or experimental therapies. Furthermore, the approach can be readily used to assess the effect of pharmacological manipulations on myelin, providing a tool to better understand myelination and develop effective therapeutic strategies to treat myelin-related diseases. Supported by National Science Centre grant: 05728/B/NZ4/2011/01

12

Sex-dependent changes in cerebellar thyroid hormone-dependent gene expression following perinatal exposure to thimerosal in rats

63%

Khan A., Sulkowski Z. L., Chen T., Zavacki A. M., Sajdel-Sulkowska E. M.

Journal of Physiology and Pharmacology

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2012

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tom 63

|

nr 3

13

Ultrastructural picture of rat cerebellum in culture subjected to the action of antiglial immune serum

63%

Weinrauder H., Gajkowska B.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1987

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tom 35

|

nr 1-3

14

Contribution of neuronal nitric oxide (NO) synthase to N-acetylcysteine-induced increase of NO synthase activity in the brain of normotensive and hypertensive rats

63%

Pechanova O., Kunes J., Dobesova Z., Vrankova S., Zicha J.

Journal of Physiology and Pharmacology

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2009

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tom 60

|

nr 4

21-25

The goal of our study was to determine a contribution of nNOS to the increase of brain NO synthase activity induced by chronic N-acetylcysteine (NAC) treatment. Young 4-week-old male Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were subjected to treatment with NAC (1.5 g/kg/day) for 8 weeks. At the end of experiment total NOS activity was determined in the brainstem and cerebellum with and without specific nNOS inhibitor S-methyl-L-thiocitrulline (SMTC, 10-6 mol/l) by measuring the formation of L-[3H] citrulline from L-[3H] arginine. Chronic NAC treatment had no effect on blood pressure (BP) of WKY, while it attenuated BP increase in young SHR. Total NOS activity was increased in the brainstem of SHR compared to WKY, but this strain difference was abolished by SMTC. Chronic NAC treatment of SHR increased total NOS activity by 32% in the brainstem and by 67% in the cerebellum. After the incubation of brainstem and cerebellum with SMTC there were no significant differences in NOS activity of NAC-treated rats compared to strain-matched controls. Taken together, nNOS seems to be responsible for the increase of total NOS activity in the brain of SHR. SMTC inhibited 86% and 70% of NAC-induced increase of total NOS activity in the brainstem and cerebellum, respectively. Thus, nNOS is responsible not only for strain differences but also for NAC-induced increase of total NOS activity in the brain.

15

Vascularization of the brain in guinea pig. III. Vascular architecture of the medulla oblongata, pons, and cerebellum

63%

Majewska-Michalska E.

Folia Morphologica

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1997

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tom 56

|

nr 1

16

Pontocerebellar projection to the rabbit paramedian lobule by means of axonal collaterals: evidence for intralobular connections

63%

Bukowska D., Zguczynski L., Mierzejewska-Krzyzowska B.

Acta Neurobiologiae Experimentalis

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2003

|

tom 63

|

nr 4

17

Histochemical detection of dystrophin in Purkinje neurons of mouse cerebellum

63%

Rowinski J., Kozlowska H., Gorecki D. C., Barnard E. A.

Folia Morphologica

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1996

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tom 55

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nr 4

18

The cerebellar paraflocculus and the subarcuate fossa in Monodelphis domestica and other marsupial mammals - ontogeny and phylogeny of a brain-skull interaction

63%

Sanchez-Villagra M. R.

Acta Theriologica

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2002

|

tom 47

|

nr 1

The development of the subarcuate fossa and the cerebellar paraflocculus was studied in an ontogenetic series of Monodelphis domestica Wagner, 1842 The spatial relation between these structures was examined qualitatively in adult specimens of several marsupial taxa. The fossa is first formed without participation of the cerebellar paraflocculus, which fills the fossa first fully and then partially later in development. The correlation between the size of the petrosal lobule of the paraflocculus and the subarcuate fossa in adults is weak. The volume of the subarcuate fossa was measured in 68 specimens representing 19 species of recent marsupials. Its size is negatively allometric with respect to skull size. The didelphids examined ('large opossums') have relatively smaller subarcuate fossae than the other marsupials examined, and Sarco- philus laniarius is the major outlier, with a very small fossa. Loss of the subarcuate fossa has occurred at least twice in metatherian evolution (some sparassodonts and wombats). All marsupials examined to date, with the exception of wombats, have a differentiated petrosal lobule of the paraflocculus.

19

Cerebellar abnormality in autism: a nonspecific effect of early brain damage?

63%

Ciesielski K. T., Knight J. E.

Acta Neurobiologiae Experimentalis

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1994

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tom 54

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nr 2

20

Effect of cadmium and ionizing radiation on DNA and RNA content in the rat hemispheres and cerebellum

63%

Klimova S., Misurova E.

Bulletin of the Veterinary Institute in Puławy

|

2002

|

tom 46

|

nr 1

Ograniczanie wyników

Fractal description of cerebellum surface during fetal period

The tetraploidy of Purkinje cells in the cerebellum in reference to the problem of polyploidy

Fractal analysis of adults cerebellum surface NMR observations

An influence of lesions of the catecholaminergic cerebellar innervation on the harmaline-induced tremor in rats

Venous angioarchitecture of human cerebellum in fetal period

The early development of the external germinal layer of the human embryonic cerebellum

Effect of alkylating drugs on rat cerebellum

Arteries that supply the brain and the formation of circulus arteriosus cerebri in donkeys

Spontaneous and evoked activities of interpositus nucleus neurons before and after lesion of the cerebellar cortex

Effect of sex and localization dependent differences of Na,K-ATPase properties in brain of rats

New method of longitudinal spinal cord slice culture

Sex-dependent changes in cerebellar thyroid hormone-dependent gene expression following perinatal exposure to thimerosal in rats

Ultrastructural picture of rat cerebellum in culture subjected to the action of antiglial immune serum