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The study was designed to assess the antioxidant defense mechanisms, either enzymatic or non-enzymatic, in a group of sixteen centenarians (one male and fifteen female subjects aged 101 to 105 years) living in the Upper Silesia district (Poland) in order to evaluate the potential role of antioxidant defenses in human longevity. The results of our preliminary study showed that in comparison with young healthy female adults the centenarians had significantly higher red blood cell glutathione reductase and catalase activities and higher, although insignificantly, serum vitamin E level.
The aim of the study was to determine the preferences and nutritional habits of Warsaw centenarians during their "third period" of life. The study was conducted by a questionnaire method among 29 centenarians. Most of centenarians had general good health condition. Almost 60% of centenarians performed manual labor in the past. Then they drank small amounts of alcohol irregularly. Several percent of centenarians smoked in the past. Before the age of sixty less people then at present snacked between meals. Sweets both now and in the past were preferred products, however, in the past sweets were rarely eaten by centenarians. At the present time centenarians ate more often yogurt, skim curd, fish, lean meat products, plant oils and sweets. The changes in eating habits were probably caused by civilization changes.
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Neuroendocrine control of metabolic homeostasis in Polish centenarians

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Neuropeptides play a pivotal role in the control of metabolic homeostasis. We aimed to evaluate the release of neuropeptides involved in the control of energy homeostasis in relation to metabolic status in aging humans. The study group consisted of 183 women: 75 centenarians (above 100 yrs old), 26 elderly women (below 70 yrs), 45 younger women (mean 26 yrs) and 37 obese women (mean 41.6 yrs). Fasting plasma concentration of leptin, adiponectin, ghrelin active, neuropeptide Y (NPY) and insulin were measured. Our results showed several differences in the metabolic and neurohormonal status in the centenarian group. The incidence of hypertension, glucose intolerance, insulin resistance and dyslipidemia was lower compared with obese women. Leptin and NPY concentrations were significantly lower than in elderly and obese subjects. Moreover, NPY level was higher than that in the younger group. Plasma adiponectin values were higher than in any of the other group. Insulin levels were significantly lower compared with the young and obese groups. Furthermore, a negative correlation was found between adiponectin and HOMA-IR, and adiponectin and insulin. Ghrelin active concentrations were significantly lower compared with the young subjects. However, ghrelin levels were higher than in obese subjects. We conclude that altered neuropeptide activity in centenarians may play a role in the mechanisms contributing to prolonged survival.
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Anthropometric chest structure of Polish centenarians

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The aim of the study was to analyze somatometric chest structure in persons aged over 100 years. The study group included 83 women and 13 men, aged 100-108 yr (median age -100.8 yr), who participated in the scientific project: 'Genetic and Environmental Factors of Longevity of Polish Centenarians' in 2002-2004. The Rohrer index of chest structure using acromion-acromion length and body height were compared with the results of pulse oximetry, spirometry, and the level of general physical activity. The majority of the centenarians had a pyknic structure of the chest, most likely as a result of a progressive reduction of body height and chest stooping. In comparison with the women who had marked alterations of chest structure, females with less profound changes had a lower respiratory rate, better tolerance of exercise, higher forced vital capacity, and a higher physical activity. A small number of male subjects studied made it impossible to analyze statistical correlations in this group. We conclude that there is a need to redefine anthropometric indices for a reliable assessment of chest structure in senescent subjects.
The aim of the study was to assess energy, protein, fat and carbohydrates intake by centenarians living in Warsaw. The study was conducted between the years 2001 and 2004. An average dietary energy covered only approximately 81% of Polish RDA for elderly people over 60 years of age, and for 7 persons (1 male and 6 females) was lower than 66.7% of the RDA. Protein and fat intake fully covered nutritional recommendations for these nutrients with exception of 2 women for protein and 4 women for fat. The energy distribution figures were slightly higher for protein and fat, while for carbohydrates lower than recommended. It is very difficult to assess whether energy and nutrient intake by centenarians were adequate because of a lack of nutritional recommendations for such old people. It is necessary to determine the RDA values for a group of 85+ years old.
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