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Transcription factors in cellular senescence and death

100%

Sikora E.

Acta Biochimica Polonica

1993

tom 40

nr 3

p21WAF1 and hypoxia/reoxygenation-induced premature senescence of H9c2 cardiomyocytes

51%

Wang D., Zhang Y.-Z., Yang B., Zhang F.-X., Cao M.-Y., Wang C., Chen M.-L.

Folia Histochemica et Cytobiologica

2011

tom 49

nr 3

Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence

51%

Wesierska-Gadek J., Ranftler C., Schmid G.

Journal of Physiology and Pharmacology. Supplement

2005

tom 56

nr 2

77-88

Ageing of organisms is among the most complex processes currently known. Understanding the molecular mechanism of physiological ageing is one of the most essential issues in biology and medicine because it is not possible to predict when and how a certain individual will start ageing. In the past centuries human life expectancies increased. Extension of life span is associated with increased susceptibility to a number of chronic diseases. Insight into the cellular and molecular targets of the ageing process would offer the opportunity to prevent at least some of the destructive processes. In the present paper the involvement of two tumor suppressor proteins: wild-type p53 and poly(ADP-ribose)polymerase-1 (PARP-1) in the regulation of cellular senescence and physiological ageing was reviewed. Moreover, the interaction and cross-talk between p53 and PARP1-1 was discussed.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Folia Histochemica et Cytobiologica

1 Journal of Physiology and Pharmacology. Supplement

1 Cao M.-Y.

1 Chen M.-L.

1 Ranftler C.

1 Schmid G.

1 Sikora E.

1 Wang C.

1 Wang D.

1 Wesierska-Gadek J.

1 Yang B.

1 Zhang F.-X.

1 Zhang Y.-Z.

1 2011

1 2005

1 1993

Wyniki wyszukiwania

Transcription factors in cellular senescence and death

p21WAF1 and hypoxia/reoxygenation-induced premature senescence of H9c2 cardiomyocytes

Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence