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  1. 6 Cellular and Molecular Biology Letters

  2. 6 Folia Histochemica et Cytobiologica

  3. 5 Journal of Physiology and Pharmacology

  4. 4 Folia Biologica

  5. 2 Acta Biochimica Polonica

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  1. 5 Madeja Z.

  2. 5 Sroka J.

  3. 2 Czyz J.

  4. 2 Janik P.

  5. 2 Korohoda W.

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  1. 1 2018

  2. 2 2017

  3. 1 2015

  4. 1 2014

  5. 1 2012

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1

Promoting phorbol-ester-TPA enhances migration of C3H 10T1-2 cells. The role of protein kinase C and its relation to carcinogenesis

100%
Janik P., Szaniawska B., Kowalczyk D., Maternicka K.
Folia Biologica
|
1995
|
tom 43
|
nr 3-4
2

Development of the human cerebral cortex: cortical patterning and migration

86%
Wozniak W.
Acta Biologica Cracoviensia. Series Botanica. Supplement
|
2008
|
tom 50
|
nr 1
3

Ascorbic acid inhibits the migration of Walker 256 carcinosarcoma cells

86%
Wybieralska E., Koza M., Sroka J., Czyz J., Madeja Z.
Cellular and Molecular Biology Letters
|
2008
|
tom 13
|
nr 1
103-111
The results of several experimental studies have shown that ascorbic acid inhibits tumor growth and metastasis. Ascorbic acid is an antioxidant that acts as a scavenger for a wide range of reactive oxygen species (ROS). Both tumour metastasis and cell migration have been correlated with the intracellular ROS level, so it was postulated that the inhibitory effect of ascorbic acid derivatives on cell motility may be caused by scavenging of ROS. Time-lapse analyses of Walker 256 carcinosarcoma cell migration showed that both the speed of movement and the cell displacement were inhibited by ascorbic acid applied in concentrations ranging from 10 to 250 μM. This effect correlated with a reduction in the intracellular ROS level in WC 256 cells, suggesting that ROS scavenging may be a mechanism responsible for the inhibition of WC 256 cell migration. However, another potent antioxidant, N-acetyl-L-cysteine, also efficiently decreased the intracellular ROS level in WC 256 cells, but did not affect the migration of the investigated cells. These results demonstrate that intact, unmodified ascorbic acid applied in physiologically relevant and nontoxicconcentrations exerts an inhibitory effect on the migration of WC 256 carcinosarcoma cells, and that this may be one of the factors responsible for the anti-metastatic activity of vitamin C. However, our data does not support the hypothesis that the scavenging of intracellular ROS is the main mechanism in the inhibition of cancer cell migration by ascorbic acid.
4

Sodium hydrosulfide exerts a transitional attenuating effect on spermatozoa migration in vitro

86%
Wilinski B., Wilinski J., Gajda M., Jasek E., Somogyl E., Glowacki M., Sliwa L.
Folia Biologica
|
2015
|
tom 63
|
nr 2
5
Content available remote

Impairment by allyl isothiocyanate of gastric epithelial wound repair through inhibition of ion transporters

86%
Hayashi S., Nakamura E., Kubo Y., Takahashi N., Yamaguchi A., Matsui H., Hagen S. J., Takeuchi K.
Journal of Physiology and Pharmacology
|
2008
|
tom 59
|
nr 4
691-706
Isothiocyanate is a transient receptor potential ankyrin 1 (TRPA1) agonist and also an inhibitor of ion transporters such as anion exchanger (AE) and Na+/HCO3- co-transporter (NBC). We examined the expression of TRPA1 and ion transporters in monolayers of the rat gastric epithelial cell line RGM1 and investigated the involvement of these factors in the inhibitory action of isothiocyanate on epithelial wound healing. After obtaining a confluent monolayer, a round artificial wound of constant size was induced in the center of the cell monolayer using a pencil-type mixer with a rotating silicon tip. Immediately after the wound induction, cells at the edge of the wound started to form lamellipodia, migrating towards the center of wound, and the cell-free area decreased with time. Addition of allyl isothiocyanate to standard buffer suppressed the recovery of the wound in a concentration-dependent manner without affecting the viability of the RGM1 cells. Icilin, another TRPA1 agonist, dose-dependently inhibited wound repair. Likewise, 4,4’-diisothio- cyanatostilbene-2,2’-disulfonic acid (DIDS), a stilbene compound containing an isothiocyanate group, also inhibited the recovery of epithelial wounds. In addition, the repair of epithelial wounds was suppressed when the cells were incubated in Na+, Cl- or HCO3- free buffer. The RGM1 cells expressed the mRNAs of AE2a and NBC1 but not TRPA1. These results suggested that isothiocyanate impairs the repair of epithelial wounds in RGM1 cells, probably through the inhibition of ion transporters such as AE2a and NBC1 and not the activation of the TRPA1 channel. It is assumed that the process of epithelial repair is associated with the regulation of cell volume and intracellular pH (pHi) by these ion transporters.
6

Comparison of proliferation and motile activity between human keratinocytes isolated from skin and oral mucosa

86%
Drukala J., Zarzecka J., Gojniczek K., Waligorska A., Zapala J., Korohoda W.
Folia Biologica
|
2005
|
tom 53
|
nr 1-2
7

Regulation of beta1 integrin expression in endothelial cells by chimeric tRNA Va1 ribozyme

86%
Papiewska-Pajak I., Antoszczyk S.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr 2
To downregulate expression of the β1 integrin subunit in endothelial cells, plasmid encoding the ribozyme cassette containing hammerhead ribozyme flanked at the 5' terminus by tRNAVal and at the 3' terminus by constitutive transport element sequences was constructed. When used to transfect immortalized human endothelial cell line EA.hy 926, it selectively blocked the synthesis of the β1 integrin subunit and thus inhibited migration and proliferation of the cells. Thus, this construct may be a valuable tool to control the proangiogenic phenotype of stimulated endothelial cells.
8

The effect of triethyllead on the motile activity of Walker 256 carcinosarcoma cells

86%
Sroka J., Kaminski R., Michalik M., Madeja Z., Przestalski S., Korohoda W.
Cellular and Molecular Biology Letters
|
2004
|
tom 09
|
nr 1
The effect of triethyllead (TriEL) on the morphology and motile activity of Walker 256 carcinosarcoma cells was investigated. It was found that both 2 and 5 μM TriEL affected the cellular motility in a dose- and time- dependent manner. Initially, 2 μM TriEL caused the formation of blebs instead of lamellipodia at the front of some cells and stimulated the migration of Walker cells, but after 2 hours of 2 μM TriEL treatment, a reduction of cellular motility was observed. In the presence of 5 μM TriEL, Walker 256 carcinosarcoma cells rounded up, and their rate of movement was reduced. Moreover, the treatment of Walker carcinosarcoma cells with TriEL caused the disruption of microtubules and affected the F-actin distribution at both concentrations. At a concentration of 2 μM TriEL, the actin staining intensity was greatest in the tail of front-tail polarised blebbing cells and the actin layer was very thin at the leading edge. The control cells showed linear cortical F-actin distribution and somewhat less intense cytoplasmic staining at the same TriEL concentration. Cells treated with 5 μM TriEL showed an under-membrane pattern of actin distribution.
9

Inhibition of EGFR nuclear shuttling decreases irradiation resistance in HeLa cells

72%
Wei H., Zhu Z., Lu L.
Folia Histochemica et Cytobiologica
|
2017
|
tom 55
|
nr 2
10

Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase gamma1 expression

72%
Zhuang L., Zhang B., Zeng G., Dai L., Qian H., Hu T., Song G., Zhang B., Xia C.
Folia Histochemica et Cytobiologica
|
2014
|
tom 52
|
nr 3
11

RSK1 promotes murine breast cancer growth and metastasis

72%
Czaplinska D., Gorska M., Mieczkowski K., Peszynska-Sularz G., Zaczek A. J., Romanska H. M., Sadej R.
Folia Histochemica et Cytobiologica
|
2018
|
tom 56
|
nr 1
12
Content available remote

Interferon lambda 2 promotes mammary tumor metastasis via angiogenesis extension and stimulation of cancer cell migration

72%
Pingwara R., Witt-Jurkowska K., Ulewicz K., Mucha J., Tonecka K., Pilch Z., Taciak B., Zabielska-Koczywas K., Mori M., Berardozzi S., Botta B., Rygiel T. P., Krol M.
Journal of Physiology and Pharmacology
|
2017
|
tom 68
|
nr 4
13

The use of an electric field to enhance bacterial movement and hydrocarbon biodegradation in soils

72%
Olszanowski A., Piechowiak K.
Polish Journal of Environmental Studies
|
2006
|
tom 15
|
nr 2
Bioremediation is the effective remediation technology for soils contaminated by biodegradable contamination. However, bioremediation of soils contaminated by hydrophobic compounds still remains a major challenge for the scientific and industrial world. There is still the need to develop techniques which allow an increase in bioremediation efficiency. A possible solution seems to be the stimulation of bacteria migration through the subsurface while using bioremediation. In this study a weak electric field in combination with the following bacterial strains: Pseudomonas putida, Bacillus subtilis and Klebsiella pneumoniae was used to stimulate bacterial cell migration, as well as the biodegradation of crude oil contamination in soil samples. Bacterial cell migration under the influence of the weak electric field and crude oil biodegradation were estimated during the experiments. The effect of changes in electrode polarization were also included in this study. Results show that weak electric field application has a great influence on the speed and direction of bacterial migration in soil samples and biodegradation of the pollution. From the study of the application of the electric field in soil bacteria migration can be forced in the desired direction and consequently stimulate biodegradation of contamination in selected areas.
14

All roads lead to Rome: pathways of NKT cells promoting asthma

72%
Jinquan T., Li W., Yuling H., Lang C.
Archivum Immunologiae et Therapiae Experimentalis
|
2006
|
tom 54
|
nr 5
15

Maspin and c-erbB-2 expression in correlation with microvessel density in invasive ductal breast cancer

72%
Sopel M., Kasprzyk I., Berdowska I.
Folia Histochemica et Cytobiologica
|
2005
|
tom 43
|
nr 2
16
Content available remote

TGF-beta signalling pathway: its role in gastrointestinal pathophysiology and modulation of ulcer healing

72%
Tanigawa T., Pai R., Arakawa T., Higuchi K., Tarnawski A. S.
Journal of Physiology and Pharmacology
|
2005
|
tom 56
|
nr 1
Gastrointestinal ulcer healing is a complex process, involving cell migration, proliferation, angiogenesis and extracellular matrix deposition, all ultimately leading to reconstruction of tissue architecture within the ulcer scar. These processes are controlled by growth factors, cytokines and hormones. Transforming growth factor-ß (TGF-ß ), one of the multifunctional peptide growth factors, has been reported to positively regulate gastrointestinal ulcer healing. Although TGF-ß inhibits cell proliferation in a variety of cells, it induces cell migration, angiogenesis, and enhances extracellular matrix production necessary for gastrointestinal ulcer healing. TGF-ß exerts its action by binding to its transmembrane serine/threonine kinase receptors, which in turn triggers activation of various intracellular signaling pathways. Smads are intermediate effector proteins that play key roles in biological activities of TGF-ß by transmitting the signals from the cell surface directly into the nucleus and initiating transcription. New insight into the mechanisms underlying TGF-ß-Smad modulation of gastrointestinal ulcer healing will likely enhance our understanding of the mechanisms controlling the healing processes of gastrointestinal ulcers.
17
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Content available

Polyamines and cell migration

72%
McCormack S. A., Johnson L. R.
Journal of Physiology and Pharmacology
|
2001
|
tom 52
|
nr 3
18
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Subserosal application of transforming growth factor-beta 1 in rats with chronic gastric ulcers: effect on gastric ulcer healing and blood flow

72%
Ernst H., Konturek P. C., Brzozowski T., Konturek S. J., Hahn E. G.
Journal of Physiology and Pharmacology
|
1996
|
tom 47
|
nr 3
19

The effect of wortmannin and promoting phorbol ester [TPA] on migration of ovary carcinoma cells

72%
Miloszewska J., Szaniawska B., Kowalczyk D., Janik P.
Cellular and Molecular Biology Letters
|
1999
|
tom 04
|
nr 2
The purpose of the present study was to determine the role of PI 3 kinase in tumor cell migration. The migration of ovary carcinoma cells (OVP10) was strongly inhibited by wortmannin to the same extent as by TPA treatment. The strongest additive inhibitory effect was noted after cell treatment with wortmannin and TPA together. Western blotting studies showed activation / partial down regulation of PKC after TPA treatment and decreased amount of the enzyme following wortmannin exposure. Altogether, it looks like wortmannin inhibits migration of studied cells.
20

Contact guidance of Walker carcinosarcoma cells by the underlying normal fibroblasts is inhibited by RGD-containing synthetic peptides

72%
Madeja Z., Sroka J.
Folia Histochemica et Cytobiologica
|
2002
|
tom 40
|
nr 3
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