Wyniki wyszukiwania

1

The kinase suppressor of Ras [KSR-1] is required for differentiation of HL60 cells induced by near-physiological levels of 1,25 dihydroxyvitamin D3

100%

Wang X., Studzinski G. P.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr Suppl.

2

Synergistic cell growth inhibition by combination of antifolates

100%

Balinska M.

Acta Biochimica Polonica

|

1993

|

tom 40

|

nr 3

3

Isolation of two xyloglucan endotransglycosylase genes that are expressed during cucumber somatic embryogenesis

75%

Malinowski R., Wisniewska A., Filipecki M., Malepszy S.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr Suppl.

4

Regulation of nuclear phospholipase C activity

75%

Manzoli L., Billi A. M., Martelli A. M., Cocco L.

Acta Biochimica Polonica

|

2004

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tom 51

|

nr 2

A body of evidence, linking inositide-specific phospholipase C (PI-PLC) to the nucleus, is quite extensive. The main isoform in the nucleus is PI-PLQCß1, whose activity is up-regulated in response to insulin-like growth factor-1 (IGF-1) or insulin stimulation. Whilst at the plasma membrane this PI-PLC is activated and regulated by Gaq/a11 and Gßy subunits, there is yet no evidence that qa/a11 is present within the nuclear compartment, neither GTP-y-S nor AlF4 can stimulate PI-PLCß1 activity in isolated nuclei. Here we review the evidence that upon occupancy of type 1 IGF receptor there is translocation to the nucleus of phosphorylated mitogen-activated protein kinase (MAPK) which phosphorylates nuclear PI-PLCß1 and triggers its signalling, hinting at a separate pathway of regulation depending on the subcellular location of PI-PLCß1. The difference in the regulation of the activity of PI-PLCß1 mirrors the evidence that nuclear and cytoplasmatic inositides can differ markedly in their signalling capability. Indeed, we do know that agonists which affect nuclear inositol lipid cycle at the nucleus do not stimulate the one at the plasma membrane.

5

Physiological and biochemical changes associated with cotton fiber development. V. Acid invertase and sugars

75%

Thaker V. S., Saroop S., Vaishnav P. P., Singh Y. D.

Acta Physiologiae Plantarum

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1992

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tom 14

|

nr 1

6

Afs1-yeast inductor of apoptosis inhibits CK2 activity in vitro

75%

Jach M., Kubinski K., Zielinski R., Sajnaga E., Szyszka R.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.2

7

Estrogen receptors in sheep ovarian follicle development

75%

Tomanek M., Pisselet C., Monget P., Madigou T., Thieulant M. L., Monniaux D.

Folia Histochemica et Cytobiologica. Supplement

|

1997

|

tom 35

|

nr 2

8

The subcellular distribution of the p53 tumour suppressor, and organismal ageing

75%

Wesierska-Gadek J., Schmid G.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr 3

9

Effect of epidermal growth factor [EGF] on Tetrahymena pyriformis

75%

Kohidai L., Keresztesi M., Csaba G.

Acta Protozoologica

|

2001

|

tom 40

|

nr 3

10

Viewing nuclear pore contraction with the atomic force microscope

75%

Rakowska A., Schneider S. W., Danker T., Schuricht B., Oberleithner H.

Cellular and Molecular Biology Letters

|

1997

|

tom 02

|

nr 2

11

Gamma linolenic acid suppresses hypoxia-induced gastric cancer cell growth and epithelial-mesenchymal transition by inhibiting the Wnt/b-catenin signaling pathway

63%

Wang Y., Shi J., Gong L.

Folia Histochemica et Cytobiologica

|

2020

|

tom 58

|

nr 2

12

Phosphorylation sites of HER2/c-erbB-2: role in cell growth and in disease

63%

Khurshid R., Saleem M., Gul-e-Raana, Akhthar M. S.

Acta Biochimica Polonica

|

2014

|

tom 61

|

nr 4

13

The identification and characterization of a new GTP-binding protein [Gbp45] involved in cell proliferation and death related to mitochondrial function

63%

Kira Y., Nishikawa M.

Cellular and Molecular Biology Letters

|

2008

|

tom 13

|

nr 4

570-584

We describe the identification and characterization of a GTP-binding protein with a molecular weight of 45 kD (Gbp45). Gbp45 cDNA was found to overlap with a hypothetical human protein, PTD004, the sequence of which was previously deposited in the databases. The gene for PTD004 was recently found to be one of the ATPases, hOLA1 (human Obg-like ATPase 1). The Gbp45 gene encodes a protein of 396 amino acid residues. Immunocytochemical analysis and examination with GFP-tagged protein revealed that Gbp45 is primarily located in the cytosolic compartment. Immunoblot analysis showed that the Gbp45 protein is strongly expressed in the neuronal tissues and pancreas. T43N and T56N mutations resulted in a loss of Gbp45’s ability to bind to GTP and a loss of GTPase activity. In cultured cells, the transfection of wild-type Gbp45 accelerated cell proliferation, though T43N and T56N mutations induced cell death. Down-regulating Gbp45 expression decreased the cell proliferation rate and increased the rate of cell death induced by the inhibition of mitochondrial electron transport. These findings indicate that Gbp45 plays important roles in cell proliferation and death related to mitochondrial function.

14

Sirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during aging

63%

Vakhrusheva O., Braeuer D., Liu Z., Braun T., Bober E.

Journal of Physiology and Pharmacology. Supplement

|

2008

|

tom 59

|

nr 9

201-212

15

The tumor supressor function of STGC3 and its reduced expression in nasopharyngeal carcinoma

63%

He X. S., Deng M., Yang S., Xiao Z.-Q., Luo Q., He Z.-M., Hu B., Chen Z.-C.

Cellular and Molecular Biology Letters

|

2008

|

tom 13

|

nr 3

339-352

STGC3 is a novel candidate tumor suppressor gene that was found to be associated with nasopharyngeal carcinoma (NPC) via the cDNA cloning and RACE processes. The biological function of the STGC3 protein and its expression level in nasopharyngeal carcinoma remain unknown. This study aimed to evaluate the STGC3 protein expression level in NPC and to investigate the inhibitory function of STGC3 as a candidate tumor suppressor gene. We assessed the expression of the STGC3 protein in NPC biopsies and normal control specimens via Western blot and immunohistochemical analysis. The expression of STGC3 as induced by doxycycline (Dox) via a tetracycline (Tet)-regulated system in human nasopharyngeal carcinoma cell line CNE2 was also established, and the effect of STGC3 restoration on the biological behavior of CNE2 was observed. A reduced level of STGC3 expression (0.978 ± 0.213 versus 0.324 ± 0.185, P < 0.05) was detected in NPC versus normal nasopharyngeal tissue by Western blot assay. Immunohistochemical assays for STGC3 detected positive staining in the nuclei and cytoplasm of epithelial cells, and the positive expression rate in NPC, 8 of 21 (38%), was lower than that in normal nasopharynx samples, 16 of 22 (72%). After STGC3 expression was restored, the growth capacity and clone formation potential of CNE2 cells in soft agar were significantly suppressed, and the cell percentage in G0/G1 phase increased, while the percentage of cells entering the S and G2 phases decreased. This indicates that an abnormality in STGC3 expression is associated with nasopharyngeal carcinogenesis and that it may play an important role in controlling cell growth and regulating the cell cycle.

16

Gastrin activates tyrosine kinase and phospholipase C in isolated rat colonocytes

63%

Malecka-Panas E., Tureaud J., Majumdar A. P. N.

Acta Biochimica Polonica

|

1996

|

tom 43

|

nr 3

Postreceptor regulation of the trophic action of gastrin is not fully elucidated. Tyrosine kinase (Tyr-kinase) has been associated with receptors of a number of growth factors and plays an important role in regulation of cellular growth within the gastrointestinal tract. The aim of this study was to determine, whether Tyr-kinase plays a role in mediating the growth promoting action of gastrin and whether phospholipase C (PLC) is involved in the signal transduction pathway. Colonocytes isolated from Fischer 344 rats were incubated for 2 min with gastrin (10-8 M) and assayed for Tyr-kinase and PLC activities. Incubations with gastrin resulted in 60%-70% rise in Tyr-kinase and 150%-200% rise in PLC activities over the corresponding basal levels. When processed separately, in proximal colon Tyr-kinase activation by gastrin was 15%-20%, while in distal colon 70%-80% as compared to the buffer control. Gastrin activation of both Tyr-kinase and PLC was abolished by Tyr-kinase inhibitor, tyrphostin-25 (3.2 nM) and was not affected by staurosporine (20 ng/ml). We conclude that Tyr-kinase is involved in the mechanism of trophic action of gastrin, and PLC activation appears to be the next step in the signal transduction pathway.

17

The role of SMG-1, a member of the PIKK [phosphoinositide 3-kinase related kinases] family, in mRNA surveillance; Molecular mechanism and therapeutic implications

63%

Ohno S.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.2

18

Effect of symplasmic isolation and antigibberellin treatment on morphogenesis in Chara

63%

Kwiatkowska M.

Folia Histochemica et Cytobiologica

|

1995

|

tom 33

|

nr 2

19

The effect of rh TNF-alpha on morphology of placenta in pregnant rabbits

63%

Terlikowski S., Sulkowski S.

Folia Histochemica et Cytobiologica

|

1997

|

tom 35

|

nr 2

20

When [2-3H]inositol is added to intra-abdominal Ehrlich tumour cell growths in mice, the ATP and GTP of the harvested cells are stably labelled with 3H in both ribose and base

63%

Christensen S., Klenow H., Overgaard-Hansen K.

Cellular and Molecular Biology Letters

|

1999

|

tom 04

|

nr 3

Ograniczanie wyników

The kinase suppressor of Ras [KSR-1] is required for differentiation of HL60 cells induced by near-physiological levels of 1,25 dihydroxyvitamin D3

Synergistic cell growth inhibition by combination of antifolates

Isolation of two xyloglucan endotransglycosylase genes that are expressed during cucumber somatic embryogenesis

Regulation of nuclear phospholipase C activity

Physiological and biochemical changes associated with cotton fiber development. V. Acid invertase and sugars

Afs1-yeast inductor of apoptosis inhibits CK2 activity in vitro

Estrogen receptors in sheep ovarian follicle development

The subcellular distribution of the p53 tumour suppressor, and organismal ageing

Effect of epidermal growth factor [EGF] on Tetrahymena pyriformis

Viewing nuclear pore contraction with the atomic force microscope

Gamma linolenic acid suppresses hypoxia-induced gastric cancer cell growth and epithelial-mesenchymal transition by inhibiting the Wnt/b-catenin signaling pathway

Phosphorylation sites of HER2/c-erbB-2: role in cell growth and in disease

The identification and characterization of a new GTP-binding protein [Gbp45] involved in cell proliferation and death related to mitochondrial function

Sirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during aging

The tumor supressor function of STGC3 and its reduced expression in nasopharyngeal carcinoma

Gastrin activates tyrosine kinase and phospholipase C in isolated rat colonocytes

The role of SMG-1, a member of the PIKK [phosphoinositide 3-kinase related kinases] family, in mRNA surveillance; Molecular mechanism and therapeutic implications

Effect of symplasmic isolation and antigibberellin treatment on morphogenesis in Chara