Wyniki wyszukiwania - AGRO

1

Mechanisms of DNA damage and repair, studied during the cell cycle

100%

Rzeszowska J.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

2

The influence of cAMP and calcium on the modulation of the MP and ion conductivity in developing embryos

88%

Chaban V., Goida E.

Biophysics of Membrane Transport

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1994

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tom 12

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nr 2

3

The effect of lead on cyclin expression in lupine roots

88%

Deckert J., Gwozdz E. A.

Acta Physiologiae Plantarum

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1999

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tom 21

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nr 3

4

DNA replication reaction in Xenopus cell-free system is suppressed by high pressure

88%

Takahashi H., Yamaguchi T., Koga M., Kageura H., Terada S.

Cellular and Molecular Biology Letters

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2004

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tom 09

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nr 3

Previously, we demonstrated that when mouse erythroleukemia cells are exposed to a pressure of 80 MPa, the cell-cycle progression of S-phase cells is retarded. To examine the effects of high pressure on DNA replication, we used a Xenopus cell-free system. From cell-cycle progression of sperm nuclei, it was found that sperm nuclei are stable to a pressure of 80 MPa, whereas egg extracts are susceptible to high pressure. Similarly, biotin-16-dUTP was incorporated into 80 MPa-treated sperm nuclei in pressure-untreated extracts, but not into naive sperm nuclei in 80 MPa-treated extracts. These results indicate that DNA replication in Xenopus cell-free system is suppressed by the susceptibility of the extracts to a pressure of 80 MPa.

5

A characterization of the temperature-sensitivity of an ovarian carcinoma cell line [OvBH-1], independent of p53 status

88%

Bar J. K., Harlozinska A., Wyrodek W., Kartarius S., Montenarh M., Rodriguez-Parkitna J. M., Kochman M., Ozyhar A.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

6

Genes regulating the cell cycle, mitosis and meiosis

88%

Rogalska S. M.

Prace Naukowe Uniwersytetu Śląskiego w Katowicach

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1998

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tom 1696

7

Structural studies on CDK2-inhibitor complexes

88%

Endicott J.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

8

Influence of G2 arrest on the cytotoxicity of DNA topoisomerase inhibitors toward human carcinoma cells with different p53 status

88%

Bozko P., Larsen A. K., Raymond E., Skladanowski A.

Acta Biochimica Polonica

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2002

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tom 49

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nr 1

We here report the influence of the cell cycle abrogator UCN-01 on RKO human colon carcinoma cells differing in p53 status following exposure to two DNA damaging agents, the topoisomerase inhibitors etoposide and camptothecin. Cells were treated with the two drugs at the IC90 concentration for 24 h followed by post-incubation in drug-free medium. RKO cells expressing wild-type, functional p53 arrested the cell cycle progression in both the Gj and G2 phases of the cell cycle whereas the RKO/E6 cells, which lack functional p53, only arrested in the G2 phase. Growth-arrested cells did not resume proliferation even after prolonged incubation in drug-free medium (up to 96 h). To evaluate the importance of the cell cycle arrest on cellular survival, a non-toxic dose of UCN-01 (100 nM) was added to the growth-arrested cells. The addition of UCN-01 was accompanied by mitotic entry as revealed by the appearance of condensed chromatin and the MPM-2 phosphoepitope, which is characteristic for mi- totic cells. G2 exit and mitotic transit was accompanied by a rapid activation of caspase-3 and apoptotic cell death. The influence of UCN-01 on the long-term cytotoxic effects of the two drugs was also determined. Unexpectedly, abrogation of the G2 arrest had no influence on the overall cytotoxicity of either drug. In contrast, addition of UCN-01 to cisplatin-treated RKO and RKO/E6 cells greatly increased the cytotoxic effects of the alkylating agent. These results strongly suggest that even prolonged cell cycle arrest in the G2 phase of the cell cycle is not necessarily coupled to efficient DNA repair and enhanced cellular survival as generally believed.

9

Rapid proliferation of activated lymph node CD4plus T cells is achieved by greatly curtailing the duration of gap phases in cell cycle progression

75%

Mishima T., Toda S., Ando Y., Matsunaga T., Inobe M.

Cellular and Molecular Biology Letters

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2014

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tom 19

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nr 4

Peripheral T cells are in G0 phase and do not proliferate. When they encounter an antigen, they enter the cell cycle and proliferate in order to initiate an active immune response. Here, we have determined the first two cell cycle times of a leading population of CD4+ T cells stimulated by PMA plus ionomycin in vitro. The first cell cycle began around 10 h after stimulation and took approximately 16 h. Surprisingly, the second cell cycle was extremely rapid and required only 6 h. T cells might have a unique regulatory mechanism to compensate for the shortage of the gap phases in cell cycle progression. This unique feature might be a basis for a quick immune response against pathogens, as it maximizes the rate of proliferation.

10

The use of quantitative methods of cytochemical studies covering the nuclear chromatin in the determination of cell cycle phases. I. Feulgen method

75%

Kowalska E.

Folia Morphologica

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1986

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tom 45

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nr 1

11

Tobacco smoking alters the number of oral epithelial cells with apoptotic features

75%

Michcik A., Cichorek M., Daca A., Chomik P., Wojcik S., Zawrocki A., Wlodarkiewicz A.

Folia Histochemica et Cytobiologica

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2014

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tom 52

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nr 1

12

Impact of roscovitine, a selective CDK inhibitor, on cancer cells: bi-functionality increases its therapeutic potential

75%

Wesierska-Gadek J., Brzoza A., Komina O., Maurer M.

Acta Biochimica Polonica

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2009

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tom 56

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nr 3

495-501

Increased expression and activity of proteins driving cell cycle progression as well as inactivation of endogenous inhibitors of cyclin-dependent kinases (CDKs) enhance the proliferative potential of cells. Escape of cells during malignant transformation from the proper cell cycle control rendering them independent from growth factors provides rationale for therapeutic targeting of CDKs. Exposure of rapidly growing human MCF-7 breast cancer and HeLa cervix cancer cells to roscovitine (ROSC), a selective inhibitor of CDKs, inhibits their proliferation by induction of cell cycle arrest and/or apoptosis. The outcome strongly depends on the intrinsic traits of the tumor cells, on their cell cycle status prior to the onset of treatment and also on ROSC concentration. At lower dose ROSC primarily inhibits the cell cycle-related CDKs resulting in a strong cell cycle arrest. Interestingly, ROSC arrests asynchronously growing cells at the G2/M transition irrespective of the status of their restriction checkpoint. However, the exposure of cancer cells synchronized after serum starvation in the late G1 phase results in a transient G1 arrest only in cells displaying the intact G1/S checkpoint. At higher dosage ROSC triggers apoptosis. In HeLa cells inhibition of the activity of CDK7 and, in consequence, that of RNA polymerase II is a major event that facilitates the initiation of caspase-dependent apoptosis. In contrast, in the caspase-3-deficient MCF-7 breast cancer cells ROSC induces apoptosis by a p53-dependent pathway. HIPK2-mediated activation of the p53 transcription factor by phosphorylation at Ser46 results in upregulation of p53AIP1 protein. This protein after de novo synthesis and translocation into the mitochondria promotes depolarization of the mitochondrial membrane.

13

The use of quantitative methods of cytochemical studies covering the nuclear chromatin in the determination of cell cycle phases. II. Method of autoradiography

75%

Kowalska E.

Folia Morphologica

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1986

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tom 45

|

nr 2

14

3-Fluoromethcathinone, a structural analog of mephedrone, inhibits growth and induces cell cycle arrest in HT22 mouse hippocampal cells

75%

Siedlecka-Kroplewska K., Szczerba A., Lipinska A., Slebioda T., Kmiec Z.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 2

15

Integration of oral structures in cdaA1 mutant of Tetrahymena thermophila

75%

Kaczanowska J.

Acta Protozoologica

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1990

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tom 29

|

nr 4

16

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Reduced expression of AURKA in peripheral blood of breast cancer patients

75%

Goh L. P. W., See E. U. H., Chua K. H., Lee P.-C.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2018

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tom 99

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nr 1

17

Protein and siRNA delivery by transportan and transportan 10 into colorectal cancer cell lines

75%

Wierzbicki P. M., Kogut-Wierzbicka M., Ruczynski J., Siedlecka-Kroplewska K., Kaszubowska L., Rybarczyk A., Alenowicz M., Rekowski P., Kmiec Z.

Folia Histochemica et Cytobiologica

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2014

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tom 52

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nr 4

18

Protein phosphatase 2A: Variety of forms and diversity of functions

75%

Lechward K., Awotunde O. S., Swiatek W., Muszynska G.

Acta Biochimica Polonica

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2001

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tom 48

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nr 4

Protein phosphatase 2A (PP2A) comprises a diverse family of phosphoserine- and phosphothreonine-specific phosphatases present in all eukaryotic cells. All forms of PP2A contain a catalytic subunit (PP2Ac) which forms a stable complex with thestructural subunit PR65/A. The heterodimer PP2Ac-PR65/A associates with regulatory proteins, termed variable subunits, in order to form trimeric holoenzymes attributed with distinct substrate specificity and targeted to different subcellular compartments. PP2Ac activity can be modulated by reversible phosphorylation on Tyr307 and methylation on C-terminal Leu309. Studies on PP2A have shown that this enzyme may be implicated in the regulation of metabolism, transcription, RNA splicing, translation, differentiation, cell cycle, oncogenic transformation and signal transduction.

19

Effects of an inhibitor of tripeptidyl peptidase II [Ala-Ala-Phe-chloromethylketone] and its combination with an inhibitor of the chymotrypsin-like activity of the proteasome [PSI] on apoptosis, cell cycle and proteasome activity in U937 cells

75%

Bury M., Mlynarczuk I., Pleban E., Hoser G., Kawiak J., Wojcik C.

Folia Histochemica et Cytobiologica

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2001

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tom 39

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nr 2

20

Antimitotic properties of plant hormone-derived inhibitors of cyclin-dependent kinases in plant and animal cells

75%

Strnad M., Hajduch M., Havlicek L., Binarova P., Bogre L.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

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