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1

Rapid proliferation of activated lymph node CD4plus T cells is achieved by greatly curtailing the duration of gap phases in cell cycle progression

100%
Mishima T., Toda S., Ando Y., Matsunaga T., Inobe M.
Cellular and Molecular Biology Letters
|
2014
|
tom 19
|
nr 4
Peripheral T cells are in G0 phase and do not proliferate. When they encounter an antigen, they enter the cell cycle and proliferate in order to initiate an active immune response. Here, we have determined the first two cell cycle times of a leading population of CD4+ T cells stimulated by PMA plus ionomycin in vitro. The first cell cycle began around 10 h after stimulation and took approximately 16 h. Surprisingly, the second cell cycle was extremely rapid and required only 6 h. T cells might have a unique regulatory mechanism to compensate for the shortage of the gap phases in cell cycle progression. This unique feature might be a basis for a quick immune response against pathogens, as it maximizes the rate of proliferation.
2

Promoted megakaryocytic differentiation of K562 cells through oxidative stress caused by near ultraviolet irradiation

100%
Nurhayati R. W., Ojima Y., Nomura N., Taya M.
Cellular and Molecular Biology Letters
|
2014
|
tom 19
|
nr 4
Reactive oxygen species (ROS) have been proven to be important activators for various cellular activities, including cell differentiation. Several reports showed the necessity of ROS during cell differentiation of the megakaryocytic (MK) lineage. In this study, we employed near ultraviolet (near-UV) irradiation to generate endogenous oxidative stress in an MK differentiation process of K562 cells with phorbol 12-myristate 13-acetate (PMA) induction. A significant increase in the intracellular ROS level was detected on day 1 after near-UV irradiation. In the initial stage of differentiation, a shifted fraction of G1 and G2 phase cells was obtained using near-UV irradiation, giving an increased percentage of G2 phase cells (up from 31.1 to 68.7%). The near-UV irradiation-induced upregulation of the p21 gene, which is a cell cycle inhibitor, suggested that the G2 phase cells were prevented from undergoing cell division. It was found that the percentage of high ploidy (8N and 16N) cells was enhanced significantly at the later stage of the K562 cell culture with near-UV irradiation. Moreover, time-lapse analysis showed that near-UV irradiation encouraged the expression of CD41, a specific surface marker of megakaryocytes. This is the first report that the elevated oxidative stress through the near-UV irradiation promoted the MK differentiation of PMA-induced K562 cells.
3

The clinical significance of serum soluble interleukin 2 receptor concentration in lung cancer

100%
Naumnik W., Chyczewska E.
Folia Histochemica et Cytobiologica. Supplement
|
2001
|
tom 39
|
nr 1
4

Alteration of parafollicular [C] cells activity in the experimental model of hypothyroidism in rats

100%
Zbucki R. L., Winnicka M. M., Sawicki B., Szynaka B., Andrzejewska A., Puchalski Z.
Folia Histochemica et Cytobiologica
|
2007
|
tom 45
|
nr 2
5

Quantitative RT-PCR assay for mRNA of VEGF and histones H2b, H4 in determination of proliferative and angiogenic activity in vulvar pathology

100%
Michalski B., Mazurek U., Olejek A., Graniczka M., Loch T., Wilczok T., Poreba R.
Folia Histochemica et Cytobiologica. Supplement
|
2001
|
tom 39
|
nr 1
6

Cannabinoids enhance gastric X-A - like cells activity

84%
Zbucki R. L., Sawicki B., Hryniewicz A., Winnicka M. M.
Folia Histochemica et Cytobiologica
|
2008
|
tom 46
|
nr 2
219-224
7

The influence of AB0 blood groups, Rh antigens and cigarette smoking on the level of NK activity in normal population

84%
Lasek W., Jakobisiak M., Plodziszewska M., Gorecki D.
Archivum Immunologiae et Therapiae Experimentalis
|
1989
|
tom 37
|
nr 3-4
8

Prolongation of heart graft survival and spleen suppressor cell activity after donor specific blood transfusions in rats differing accross the MHC

84%
Wasowska B., Adamczyk G., Ryffa T., Ziolkowska H., Olszewski W. L.
Archivum Immunologiae et Therapiae Experimentalis
|
1989
|
tom 37
|
nr 1-2
9

ETS transcription factors and regulation of immunity

84%
Gallant S., Gilkeson G.
Archivum Immunologiae et Therapiae Experimentalis
|
2006
|
tom 54
|
nr 3
10

Effect on peripheral blood natural killer cytotoxic cell activity in rats after intraperitoneal implantation of double veloured polyester [Dacron] prosthesis

84%
Jurkowski M. K., Bobek-Billewicz B., Cwiklinska-Jurkowska M., Jurkowski P.
Archivum Immunologiae et Therapiae Experimentalis
|
2004
|
tom 52
|
nr 2
11
Content available remote

Functional-eicosanoid-test (FET) and disease

67%
Baenkler H.-W.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 12
65-72
Eicosanoids are involved in most cellular activities. Measurement of their levels in tissue or blood renders information about the function of activated cells. An extended analysis will improve the conclusions regarding eicosanoid-related diseases. Peripheral white blood cells (WBC) were used for the test. Stimulating or inhibiting substances to influence the generation and the metabolism of eicosanoids were separately added to the samples. Prostaglandins (PG) and leukotrienes (LT) were measured after incubation in culture medium for 20 minutes at room temperature. Healthy controls rendered normal data. Patients with intolerance to acetylsalicylic acid (ASS) showed an elevated output of PG and LT upon stimulation. Addition of ASS shifted from PG to LT. An altered pattern of eicosanoids also was found in patients suffering from gastroduodenal ulcer and in intestinal malignancy. The senstivity regarding the ASS-intolerance is >80% and the specifity in the same group >70%. We concluded that the FET is a suitable test for the demonstration and verification of intolerance to ASS. It also detects an imbalance of the eicosanoids in intestinal malignancy. This makes the FET a helpful tool for diagnosis and for the elucidation of pathogenic mechanisms.
12

Immunoreactivity of ATF-2 and Fra-2 in human dental follicle

67%
Bolat I., Keklikoglu N.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 2
197-201
13

Improvement of growth and some metabolites of the salt affected Anabaena circinalis by calcium

67%
Hifney A. F.
Journal of Biology and Earth Sciences
|
2013
|
tom 03
|
nr 1
14

Recombinant tumor necrosis factor alpha inhibits growth of methylcholanthrene-induced sarcoma and enhances natural killer activity of tumor-infiltrating lymphocytes in aging rats

67%
Ziolkowska M., Nowak J. J., Janiak M., Ryzewska A.
Archivum Immunologiae et Therapiae Experimentalis
|
1993
|
tom 41
|
nr 5-6
15

Rhythms of immunity

67%
Plytycz B., Seljelid R.
Archivum Immunologiae et Therapiae Experimentalis
|
1997
|
tom 45
|
nr 2-3
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