Wyniki wyszukiwania

1

Pharmacological caspase inhibitors: research towards therapeutic perspectives

100%

Kudelova J., Fleischmannova J., Adamova E., Matalova E.

Journal of Physiology and Pharmacology

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2015

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tom 66

|

nr 4

2

Immunolocalization of leptin receptor and mRNA expression of leptin and estrogen receptors as well as caspases in the chorioallantoic membrane (CAM) of the chicken embryo

84%

Grzegorzewska A. K., Lis W., Sechman A.

Folia Biologica

|

2016

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tom 64

|

nr 2

3

Orexin A modulates endocrine function and viability of porcine pancreatic islets

84%

Sassek M., Pruszynska-Oszmalek E., Nowak K. W.

Journal of Physiology and Pharmacology

|

2017

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tom 68

|

nr 6

4

In vitro effects of TCDD, PCB126 and PCB153 on estrogen receptors, caspases and metalloproteinase-2 mRNA expression in the chicken shell gland

84%

Hrabia A., Lesniak A., Sechman A.

Folia Biologica

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2013

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tom 61

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nr 3-4

5

Activation of the intrinsic and extrinsic pathways in high pressure-induced apoptosis of murine erythroleukemia cells

84%

Yamaguchi T., Hashiguchi K., Katsuki S., Iwamoto W., Tsuruhara S., Terada S.

Cellular and Molecular Biology Letters

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2008

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tom 13

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nr 1

49-57

We previously demonstrated that caspase-3, an executioner of apoptosis, is activated in the pressure-induced apoptosis of murine erythroleukemia (MEL) cells (at 100 MPa). Here, we examined the pathway of caspase-3 activation using peptide substrates and caspase inhibitors. Using the substrates of caspases-8 and -9, it was found that both are activated in cells under high pressure. The production of nuclei with sub-G1 DNA content in 100 MPa-treated MEL cells was suppressed by inhibitors of caspases-8 and -9, and pan-caspase. In 100 MPa-treated cells, pan-caspase inhibitor partially prevented the cytochrome c release from the mitochondria and the breakdown of mitochondrial membrane potential. These results suggest that the intrinsic and extrinsic pathways are activated in apoptotic signaling during the high pressure-induced death of MEL cells.

6

Effect of ghrelin on the apoptosis of various cells. A critical review

84%

Kurowska P., Mlyczynska E., Rak A.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 1

7

Caspases as the key effectors of inflammatory responses against bacterial infection

84%

Uchiyama R., Tsutsui H.

Archivum Immunologiae et Therapiae Experimentalis

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2015

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tom 63

|

nr 1

8

The wine polyphenol resveratrol modulates autophagy and induces apoptosis in MOLT-4 and HL-60 human leukemia cells

84%

Siedlecka-Kroplewska K., Wozniak M., Kmiec Z.

Journal of Physiology and Pharmacology

|

2019

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tom 70

|

nr 6

9

Ellagic acid protects against diabetic cardiomyopathy in rats by stimulating cardiac silent information regulator 1 signaling

84%

Altamimi J. Z., Alfaris N. A., Alshammari G. M., Alagal R. I., Aljabryn D. H., Aldera H., Alkhateeb M. A., Yahya M. M.

Journal of Physiology and Pharmacology

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2020

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tom 71

|

nr 6

10

Inhibition of fibroblast apoptosis by Borrelia afzelii, Coxiella burnetii and Bartonella henselae

84%

Chmielewski T., Tylewska-Wierzbanowska S.

Polish Journal of Microbiology

|

2011

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tom 60

|

nr 3

Apoptosis is a genetically controlled mechanism of cell death involved in the regulation of tissue homeostasis. The aim of this study was to investigate the influence of Borrelia afzelii, Coxiella burnetii, and Bartonella henselae bacteria on apoptosis measured as the level of caspase 3 activity in human fibroblast cells HEL-299. Our findings show that C. burnetii bacteria may inhibit the process of apoptosis in the host cells for a long time. This can permit intracellular survival in the host and mediatingthe development of chronic disease.

11

Bacterial putative metacaspase structure from Geobacter sulfureducens as a template for homology modelling of type II Triticum aestivum metacaspase (TaeMCAII)

84%

Dudkiewicz M. Z., Piszczek E.

Acta Biochimica Polonica

|

2012

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tom 59

|

nr 3

Metacaspases, cysteine proteases belonging to the peptidase C14 family, are suspected of being involved in the programmed cell death of plants, although their sequences and substrate specificity differ from those of animal caspases. At present, the knowledge on the metacaspase reaction mechanism is based only on biochemical data and homology models constructed on caspase templates. Here we propose a novel template for metacaspase modeling and demonstrate important advantages in comparison to the conventionally used caspase templates. We also point out the connection between plant and bacterial metacaspases, underlining the prokaryotic roots of Programmed Cell Death (PCD).

12

The DFF40-CAD endonuclease and its role in apoptosis

84%

Widlak P.

Acta Biochimica Polonica

|

2000

|

tom 47

|

nr 4

The sequential generation of large-scale DNA fragments followed by internucleosomal chromatin fragmentation is a biochemical hallmark of apoptosis. One of the nucleases primarily responsible for genomic DNA fragmentation during apoptosis is called DNA Fragmentation Factor 40 (DFF40) or Caspase-activated DNase (CAD). DFF40/CAD is a magnesium-dependent endonuclease specific for double stranded DNA that generates double strand breaks with 3'-hydroxyl ends. DFF40/CAD is activated by caspase-3 that cuts the nuclease's inhibitor DFF45/ICAD. The nuclease preferentially attacks chromatin in the internucleosomal linker DNA. However, the nuclease hypersensitive sites can be detected and DFF40/CAD is potentially involved in large-scale DNA fragmentation as well. DFF40/CAD-mediated DNA fragmentation triggers chromatin condensation that is another hallmark of apoptosis.

13

Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons

84%

Nath R., McGinnis K., Dutta S., Shivers B., Wang K. K. W.

Cellular and Molecular Biology Letters

|

2001

|

tom 06

|

nr 2

14

Stroke, myocardial infarction, acute and chronic inflammatory diseases: caspase and other apoptotic molecules as targets for drug development

84%

Kreuter M., Langer C., Kerkhoff C., Reddanna P., Kania A. L., Maddika S., Chlichlia K., Bui T. N., Los M.

Archivum Immunologiae et Therapiae Experimentalis

|

2004

|

tom 52

|

nr 3

15

Complement in cancer and cancer immunotherapy

67%

Kolev M., Towner L., Donev R.

Archivum Immunologiae et Therapiae Experimentalis

|

2011

|

tom 59

|

nr 6

16

Comparison of acetaminophen toxicity in primary hepatocytes isolated from transgenic mice with different apolipoprotein E alleles

67%

Mezera V., Kucera O., Moravcova A., Peterova E., Rousar T., Rychtrmoc D., Sobotka O., Cervinkova Z.

Journal of Physiology and Pharmacology

|

2015

|

tom 66

|

nr 6

17

Cell-specific cytotoxic effect of pyrazole derivatives on breast cancer cell lines MCF7 and MDA-MB-231

67%

Lehmann T. P., Kujawski J., Kruk J., Czaja K., Bernard M. K., Jagodzinski P. P.

Journal of Physiology and Pharmacology

|

2017

|

tom 68

|

nr 2

18

Apoptosis in lymphocytes of pancreatic cancer patients: influence of preoperative enteral immunonutrition and extensive surgery

67%

Slotwinski R., Olszewski W., Slodkowski M., Lech G., Zaleska M., Kedziora S., Wluka A., Domaszewska A., Slotwinska S., Krasnodebski W., Wojcik Z.

Archivum Immunologiae et Therapiae Experimentalis

|

2011

|

tom 59

|

nr 5

19

Caspases - their role in apoptosis and other physiological processes as revealed by knock-out studies

67%

Sadowski-Debbing K., Coy J. F., Mier W., Hug H., Los M.

Archivum Immunologiae et Therapiae Experimentalis

|

2002

|

tom 50

|

nr 1

20

Viral modulation of cell death by inhibition of caspases

67%

Cassens U., Lewinski G., Samraj A. K., Von Bernuth H., Baust H., Khazaie K., Los M.

Archivum Immunologiae et Therapiae Experimentalis

|

2003

|

tom 51

|

nr 1

Ograniczanie wyników

Pharmacological caspase inhibitors: research towards therapeutic perspectives

Immunolocalization of leptin receptor and mRNA expression of leptin and estrogen receptors as well as caspases in the chorioallantoic membrane (CAM) of the chicken embryo

Orexin A modulates endocrine function and viability of porcine pancreatic islets

In vitro effects of TCDD, PCB126 and PCB153 on estrogen receptors, caspases and metalloproteinase-2 mRNA expression in the chicken shell gland

Activation of the intrinsic and extrinsic pathways in high pressure-induced apoptosis of murine erythroleukemia cells

Effect of ghrelin on the apoptosis of various cells. A critical review

Caspases as the key effectors of inflammatory responses against bacterial infection

The wine polyphenol resveratrol modulates autophagy and induces apoptosis in MOLT-4 and HL-60 human leukemia cells

Ellagic acid protects against diabetic cardiomyopathy in rats by stimulating cardiac silent information regulator 1 signaling

Inhibition of fibroblast apoptosis by Borrelia afzelii, Coxiella burnetii and Bartonella henselae

Bacterial putative metacaspase structure from Geobacter sulfureducens as a template for homology modelling of type II Triticum aestivum metacaspase (TaeMCAII)

The DFF40-CAD endonuclease and its role in apoptosis

Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons

Stroke, myocardial infarction, acute and chronic inflammatory diseases: caspase and other apoptotic molecules as targets for drug development

Complement in cancer and cancer immunotherapy

Comparison of acetaminophen toxicity in primary hepatocytes isolated from transgenic mice with different apolipoprotein E alleles

Cell-specific cytotoxic effect of pyrazole derivatives on breast cancer cell lines MCF7 and MDA-MB-231

Apoptosis in lymphocytes of pancreatic cancer patients: influence of preoperative enteral immunonutrition and extensive surgery

Caspases - their role in apoptosis and other physiological processes as revealed by knock-out studies

Viral modulation of cell death by inhibition of caspases