Wyniki wyszukiwania

1

Angiotensin-(1-7): an active member of the renin-angiotensin system

100%

Kucharewicz I., Pawlak R., Matys T., Chabielska E., Buczko W.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 4,1

Angiotensin-(1-7) [Ang-(1-7)] is an active member of renin-angiotensin system (RAS). It counterbalances vasoconstriction, mitogenic, arrhythmogenic and prothrombotic actions of Ang II. Inducing natiuresis and diuresis opposes also the water and sodium retention produced by Ang II. Till now the specific receptor side for Ang-(1-7) has been not cloned, but the current data strongly suggest that an interaction (cross- talk) between angiotensin receptors may play a role in the effects of Ang-(1-7).

2

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Effect of work rate on cardiorespiratory response to rhythmic static exercise

100%

Grucza R., Miyamoto Y., Nakazono Y.

Journal of Physiology and Pharmacology

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1994

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tom 45

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nr 4

3

Influence of disturbed calcium-phosphate metabolism on the cardiovascular system in patients with chronic renal failure

88%

Rzeszotarski J., Walasek L., Marszalek A.

Journal of Elementology

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2005

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tom 10

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nr 4 Suppl.1

91-92

4

Aerobics and pregnancy

75%

Genti M., Serbezis V., Mavridis G.

Studies in Physical Culture and Tourism

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2009

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tom 16

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nr 4

5

The effect of omega-3 fatty acids on expression of connexin-40 in Wistar rat aorta after lipopolysaccharide administration

75%

Frimmel K., Vlkovicova J., Sotnikova R., Navarova J., Bernatova I., Okruhlicova L.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 1

6

Latest aspects of aldosterone actions on the heart muscle

75%

Kritis A. A., Gouta C. P., Liaretidou E. I., Kallaras K. I.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 1

7

Secretory functions of the vascular endothelium

75%

Vane J. R., Botting R. M.

Journal of Physiology and Pharmacology

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1992

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tom 43

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nr 3

The endothelial cells which line the blood vessels as a monolayer exert a remarkable control over the vascular system. Indeed, the endothelium can be regarded as a highly active metabolic and endocrine organ in its own right. On the hand, vasoactive substances such as serotonin and bradykinin are inactivated and on the other the cells can enzymatically produce the vasoconstrictor, angiotensin II and secrete endothelin-1 ((ET-1). Perhaps more importantly, the cells also produce two unstable vasodilator substances, which potently inhibit platelet clumping: prostacyclin and endothelium-derived relaxing factor (EDRF) which has been identified as nitric oxide (NO; 1). Both substances seem well designated as local hormones, released to influence adjacent cells. The endothelial cell, therefore, exerts control over the cardiovascular system by elaborating dilator substances as well as vasconstrictors.

8

Centrally applied vasopressin prevents posthemorrhagic hypotension in WKY rats

75%

Ufnal M., Zera T.

Acta Neurobiologiae Experimentalis

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2002

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tom 62

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nr 1

9

Nitric oxide signalling in the cardiovascular system - physiology and pathology

75%

Malinski T.

Postępy Higieny i Medycyny Doświadczalnej

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1999

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tom 53

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nr 2

10

A new face of endocannabinoids in pharmacotherapy. Part II: Role of endocannabinoids in inflammation-derived cardiovascular diseases infarction

63%

Zubrzycki M., Liebold A., Janecka A., Zubrzycka M.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 2

11

Haemodynamic responses to the dynamic exercise in subjects exposed to different gravitational conditions

63%

Puchalska L., Belkania G. S.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 11

103-113

Different types of adaptation of the cardiovascular system to the gravitational forces (hypokinetic and hyperkinetic) have been described in the healthy and the sick subjects under resting conditions. The aim of the present study was to elucidate whether haemodynamic responses to the dynamic exercise performed under various gravitational conditions are determined by the type of adaptation of the cardiovascular system to the gravitational forces at rest. The study was performed on 249 healthy men, 20-60 years old. To assess the type of regulation of the cardiovascular system arterial blood pressure (MABP), heart rate (HR), stroke volume (SV), cardiac output (CO), and systolic function (SF) of the heart were determined in each subject at rest in the upright (orthostatic state) and in the supine position. Subsequently, the subjects were performing exercise on a cycloergometer in the sitting and the supine position. Four gradually increasing workloads were applied. Measurements of HR, MABP, SV, CO, and SF were repeated at the end of each workload. SV, CO and SF were determined by means of rheography. The results revealed that in the individuals showing at rest the hypokinetic type of orthostatic cardiovascular adaptation the augmentation of CO during exercise in the sitting position was caused by significant increases of HR and SV. In contrast, the subjects with the hyperkinetic type of orthostatic adaptation the increase in CO during exercise in the sitting position was much smaller and resulted predominantly from acceleration of HR. It is concluded that the cardiovascular adaptation to the dynamic exercise depends not only on the position of the body in which the exercise is performed but it is also determined by the type of adaptation of the cardiovascular system to the gravitational forces at rest. In the sitting position the pumping capacity of the heart is significantly greater in the hypokinetic than in the hyperkinetic type of the cardiovascular regulation; this relationship being reversed during exercise in the horizontal position.

12

Crataegus special extract WS 1442: up-to-date review of experimental and clinical experiences

63%

Zorniak M., Szydlo B., Krzeminski T. F.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 4

13

The role of serotonergic 5-HT1A receptors in central cardiovascular regulation in hemorrhagic shock in rats

63%

Sowa P., Adamczyk-Sowa M., Zwirska-Korczala K., Namyslowski G., Misiolek M., Pierzchala K.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 2

14

Hypotrophic effect of long-term neuronal NO-synthase inhibition on heart and conduit arteries of the Wistar rats

63%

Kristek F., Cacanyiova S., Gerova M.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 2

21-27

We demonstrate the effect of long-term nNOS inhibition with 7-nitroindazole (7NI) on the heart and conduit arteries. Ten weeks old Wistar rats were used: two groups of controls and rats receiving 7-NI (10 mg/kg b.w./day) for 6 weeks in drinking water. Blood pressure (BP) was measured by the plethysmographic method. In first group mesenteric, carotid and coronary arteries were excised after perfusion fixation (120 mmHg) for morphological study, in second group mesenteric artery was taken for functional investigation. 7NI did not affect BP, heart/body weight was decreased. In all arteries inner diameter (ID) did not changed, wall thickness (WT) (intima+media), cross sectional area (CSA) (intima+media), and WT/ID decreased. In carotid artery volume density (VD) (percentual proportion) of intima and media did not change; VD and CSAs of endothelial and smooth muscle cells decreased, CSAs of extracellular matrix in intima and media did not change. No difference was found in relaxation of mesenteric artery to acetylcholine (10-9-10-5 mol/L). Contraction induced by transmural nerve stimulation (8Hz) augmented and contraction to exogennous noradrenaline (10-9-10-5 mol/L) attenuated. Long-term 7NI administration evoked pressure independent cardiac hypotrophy and due to decrease of endothelial and smooth muscle cell mass arterial wall hypotrophy associated with decreased contractile efficiency.

15

AVE 0991 - angiotensin-(1-7) receptor agonist, inhibits atherogenesis in apoE - knockout mice

63%

Toton-Zuranska J., Gajda M., Pyka-Fosciak G., Kus K., Pawlowska M., Niepsuj A., Wolkow P., Olszanecki R., Jawien J., Korbut R.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 2

Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes. It was also proved that Ang II promotes atherogenesis. Angiotensin-(1-7) [Ang-(1-7)] opposites Ang II action. Therefore, we would like to find out whether Ang-(1-7) receptor agonist: AVE 0991, could ameliorate atherosclerosis progression in an experimental model of atherosclerosis: apolipoprotein E (apoE) - knockout mice. AVE 0991 inhibited atherogenesis, measured both by “en face” method (7.63±1.6% vs. 14.6±2.1%) and “cross-section” method (47 235±7 546 µm2 vs. 91 416±8 357 µm2). This is the first report showing the effect of AVE 0991 on atherogenesis in gene-targeted mice.

16

Aldosterone and mineralocorticoid receptors in regulation of the cardiovascular system and pathological remodelling of the heart and arteries

63%

Sztechman D., Czarzasta K., Cudnoch-Jedrzejewska A., Szczepanska-Sadowska E., Zera T.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 6

17

Improvement in the face-name association performance after three months of physical training in elderly women

63%

Zlomanczuk P., Milczarek B., Dmitruk K., Sikorski W., Adamczyk W., Zegarski T., Tafil-Klawe M., Chesy G., Klawe J. J., Rakowski A.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

417-424

Several lines of evidence suggest that physical exercise not only influences the development of muscles, cardiovascular and respiratory systems, but also exerts a significant influence on the central nervous system. We examined the influence of strength and endurance training on cognitive performance in 33 healthy elderly volunteers (women, mean age 63.5 ±4.5 yr) over a 3-month period of supervised training program. A control group consisted of 8 age-matched (mean age 66.3 ±4.6) healthy volunteers who did not participate in any exercise training program. To evaluate the cognitive performance in our subjects we used two tests: face/name association test and Stroop test. The tests were applied shortly before and immediately after the training program. In the experimental group, a significant improvement in the association test performance, on average, from 71.6 ±7.3% to 79.7 ±7.2% (P<0.0001) was observed over the 3-month training period. There were no changes in the Stroop test results over the same time. Likewise, there were no changes in the control groups. Our data demonstrate that the training regime that is strictly followed over a relatively short period of time may improve the performance in associative memory tasks in elderly subjects. The study supports the notion that physical exercise influences cognitive performance and extend this notion to be valid for healthy elderly subjects.

18

Experimental autoimmune myocarditis in rats and therapeutic histamine H1 – H4 receptor inhibition

63%

Stasiak A., Gola J., Kraszewska K., Mussur M., Kobos J., Mazurek U., Stark H., Fogel W. A.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 6

19

The aortic valve and other heart structures of selected species of sea birds in a morphological and imaging scope

63%

Bartyzel B. J.

Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine

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2009

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tom 12

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nr 4

20

Modulation of connexin-43 by omega-3 fatty acids in the aorta of old spontaneously hypertensive rats

63%

Dlugosova K., Okruhlicova L., Mitasikova M., Sotnikova R., Bernatova I., Weismann P., Slezak J., Tribulova N.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 3

63-69

Hypertension alters expression of connexin-43 (Cx43) in cardiovascular system. The aim of the study was to investigate the effect of omega-3 polyunsaturated fatty acids (30 mg/day for 2 months) on expression of Cx43 in the aorta of 1-year-old male spontaneously hypertensive rats (SHR). Spatial distribution and expression of Cx43 in aortic wall of SHR and age-matched Lewis rats were determined by immunofluorescent method and Western blot. NO synthase (NOS) activity and endothelium-dependent relaxation of the aorta were measured as well. Immunofluorescent pattern of Cx43 was identified in endothelial and smooth muscle cells of the aorta of all experimental groups studied. However, local decrease in the number and intensity of fluorescent spots and reduced phosphorylation of Cx43 were observed in SHR in contrast to normotensive LEW. Omega-3 fatty acid diet increased Cx43 immunolabeling in endothelium and media of SHR comparing to untreated ones. Parallel, 3-fatty acids significantly elevated phosphorylation of Cx43 in the aorta of SHR (p<0.001). Despite the omega-3 fatty acids reduced blood pressure and stimulated aortic NOS activity in SHR, endothelium-dependent relaxation of the aorta did not significantly change. Results indicate that the aorta of old SHR might partially benefit from 3-PUFA supplementation due to increased Cx43 phosphorylation, NOS activity and decreased blood pressure.

Ograniczanie wyników

Angiotensin-(1-7): an active member of the renin-angiotensin system

Effect of work rate on cardiorespiratory response to rhythmic static exercise

Influence of disturbed calcium-phosphate metabolism on the cardiovascular system in patients with chronic renal failure

Aerobics and pregnancy

The effect of omega-3 fatty acids on expression of connexin-40 in Wistar rat aorta after lipopolysaccharide administration

Latest aspects of aldosterone actions on the heart muscle

Secretory functions of the vascular endothelium

Centrally applied vasopressin prevents posthemorrhagic hypotension in WKY rats

Nitric oxide signalling in the cardiovascular system - physiology and pathology

A new face of endocannabinoids in pharmacotherapy. Part II: Role of endocannabinoids in inflammation-derived cardiovascular diseases infarction

Haemodynamic responses to the dynamic exercise in subjects exposed to different gravitational conditions