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Plasma adrenomedullin response to maximal exercise in healthy subjects

100%

Krzeminski K., Mikulski T., Kruk B., Nazar K.

Journal of Physiology and Pharmacology

2003

tom 54

nr 2

The aim of the study was to find out whether maximal exercise performed by healthy young men influences plasma adrenomedullin concentration (ADM) and is the peptide level related to the cardiovascular, metabolic and hormonal changes induced by exercise. Ten subjects (age 24 ± 1.0 yr) participated in the study. They performed graded bicycle ergometer exercise until exhaustion. Heart rate (HR) and blood pressure (BP) were measured throughout the test. Before and at the end of exercise venous blood samples were taken for [ADM], noradrenaline [NA], adrenaline [A], growth hormone [hGH], cortisol and lactate [LA] determination. Plasma [ADM] decreased during exercise from 1.71 ± 0.09 to 1.53 ± 0.10 pmol × l-1 (p< 0.01). This was accompanied by increases in plasma catecholamines and [hGH], while plasma cortisol level did not change. Positive correlation was found between the exercise-induced decreases in plasma ADM and diastolic BP. Blood [LA], systolic and mean BP at the end of exercise correlated negatively with plasma [ADM]. No significant interrelationships were found between plasma ADM, catecholamines or the other hormones measured. The present data suggests, that maximal exercise inhibits ADM secretion in young healthy men. Metabolic acidosis and a decrease in peripheral resistance might be involved in this effect.

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Effects of three-day bed rest on metabolic, hormonal and circulatory responses to an oral glucose load in endurance or strength trained athletes and untrained subjects

80%

Smorawinski J., Kaciuba-Uscilko H., Nazar K., Kubala P., Kaminska E., Ziemba A. W., Adrian J., Greenleaf J. E.

Journal of Physiology and Pharmacology

2000

tom 51

nr 2

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

2 Nazar K.

1 Adrian J.

1 Greenleaf J. E.

1 Kaciuba-Uscilko H.

1 Kaminska E.

1 Kruk B.

1 Krzeminski K.

1 Kubala P.

1 Mikulski T.

1 Smorawinski J.

1 Ziemba A. W.

1 2003

1 2000

Wyniki wyszukiwania

Plasma adrenomedullin response to maximal exercise in healthy subjects

Effects of three-day bed rest on metabolic, hormonal and circulatory responses to an oral glucose load in endurance or strength trained athletes and untrained subjects