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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Sacral insufficiency fracture following rectal cancer treatment – case report

100%
Pikula A., Pikula T. S., Pastuszak M.
Journal of Pre-Clinical and Clinical Research
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2020
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tom 14
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nr 4
2

Serum matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in esophageal cancer patients

84%
Groblewska M., Mroczko B., Kozlowski M., Niklinski J., Laudanski J., Szmitkowski M.
Folia Histochemica et Cytobiologica
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2012
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tom 50
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nr 4
3
Content available remote

The assessment of serum and diagnostic peritoneal lavage concentration of matrix metalloproteinase-2, matrix metalloproteinase-9, carbohydrate antigen 19-9, and carcinoembryonic antigen in patients with pancreatic cancer and chronic pancreatitis

84%
Dranka-Bojarowska D., Lewinski A., Lekstan A., Gajda M., Ciosek J., Mrowiec S.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 5
4

Selected tumour biomarker levels in sheep with pulmonary adenomatosis

84%
Ozkan C., Yildirim S., Huyut Z., Ozbek M.
Journal of Veterinary Research
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2020
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tom 64
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nr 1
5
Content available remote

Differentiation of pancreatobiliary cancer from benign biliary strictures using neutrophil gelatinase-associated lipocalin

84%
Budzynska A., Nowakowska-Dulawa E., Marek T., Boldys H., Nowak A., Hartleb M.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 1
6
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Gullo’s syndrome – case report

84%
Rycyk A., Furtak P., Madro A., Kasztelan-Szczerbinska B., Cichoz-Lach H.
Journal of Pre-Clinical and Clinical Research
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2020
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tom 14
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nr 4
7

Carcinoembryonic antigen as an adhesion molecule

84%
Krop-Watorek A., Lisowska E.
Archivum Immunologiae et Therapiae Experimentalis
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1998
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tom 46
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nr 3
8

Adhesive properties of carcinoembryonic antigen glycoforms expressed in glycosylation-deficient Chinese hamster ovary cell lines

84%
Krop-Watorek A., Klopocki A. G., Czerwinski M., Lisowska E.
Acta Biochimica Polonica
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2002
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tom 49
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nr 1
Carcinoembryonic antigen (CEA) is an oncofoetal cell surface glycoprotein that serves as an important tumour marker for colorectal and some other carcinomas. Its immunoglobulin-like structure places CEA within the immunoglobulin superfamily. CEA functions in several biological roles including homotypic and heterotypic (with other CEA family members) cell adhesion. Cell-cell interaction can be modulated by different factors, e.g., post-translational modifications such as glycosylation. The pur­pose of this study was to examine whether changes in carbohydrate composition of CEA oligosaccharides can influence homotypic (CEA-CEA) interactions. In order to modulate glycosylation of CEA we used two different glycosylation mutants of Chi­nese hamster ovary (CHO) cells, Lec2 and Lec8. Lec2 cells should produce CEA with nonsialylated N-glycans, while Lec8 cells should yield more truncated sugar struc­tures than Lec2. Parental CHO (Pro5) cells and the glycosylation deficient mutants were stably transfected with CEA cDNA. All three CEA glycoforms, tested in a solid-phase cell adhesion assay, showed an ability to mediate CEA-dependent cell ad­hesion, and no qualitative differences in the adhesion between the glycoforms were observed. Thus, it may be assumed that carbohydrates do not play a role in homotypic adhesion, and the interactions between CEA molecules depend solely on the poly- peptide structure.
9

Clinical studies monitoring circulating and disseminated tumor cells in gastrointestinal cancers

67%
Eliasova P., Kolostova K., Kobierzycki C., Bobek V.
Folia Histochemica et Cytobiologica
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2013
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tom 51
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nr 4
10

Clinical significance of serum levels of matrix metalloproteinase 2 (MMP-2) and its tissue inhibitor (TIMP-2) in gastric cancer

67%
Mroczko B., Lukaszewicz-Zajac M., Gryko M., Kedra B., Szmitkowski M.
Folia Histochemica et Cytobiologica
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2011
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tom 49
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nr 1
11

Cytochrome P4502C9 genotype in Southeast Anatolia and possible relation with some serum tumour markers and cytokines

67%
Yilmaz N., Erbagci A. B., Aynacioglu A. S.
Acta Biochimica Polonica
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2001
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tom 48
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nr 3
Substrates for CYP2C9 include fluoxetine, phenytoin, warfarin, losartam and nu­merous nonsteroidal anti-inflammatory drugs. Polymorphisms in the coding region of the CYP2C9 gene produce variants at amino-acid residues 144 Arg/Cys and 359 Ile/Leu of the CYP2C9 protein. Individuals homozygous for Leu359 have markedly diminished metabolic capacities for most CYP2C9 substrates, the frequency of this al­lele is, however, rather low. Consistently with the modulation of enzyme activity by ge­netic and other factors, wide interindividual variability occurs in the elimination and/or dosage requirements of prototypic CYP2C9 substrates. The polymorphic en­zyme CYP2C9 takes part in the metabolism of alkylating agents and polycyclic aro­matic hydrocarbons like benzo(a)pyrene, a carcinogen present in tobacco smoke. Al­though the impact of impaired enzyme activity in metabolism of carcinogens and procarcinogens has not been fully defined, an association of CYP2C9 variant alleles to DNA adduct levels in lung tissues as well as to lung cancer risk have been reported. In this study 64 healthy subjects (44M/22F) were analysed for CYP2C9 genotype with PCR-RFLP and for serum carcinoembryonic antigen (CEA), α-fetoprotein (AFP), CA 19-9, CA 15-3, ferritin, IL-6, IL-8 concentrations by chemiluminescence or electro- chemiluminescence methods. CYP2C9*1 was found to be the most prevalent allele and CYP2C9*1/CYP2C9*1 was the most frequent genotype represented in 64% of the population in southeastern Anatolia (Gaziantep). Although slight differences in serum tumour marker and cytokine concentrations were observed for CYP2C9 genotypes the differences were statistically insignificant (P > 0.05). This could be due to the complexity of the role of CYP2C9 in benzo(a)pyrene metabo­lism as well as from other contributing factors like interindividual variability of di­verse enzymes participating in the same metabolic pathway, unequal expression of the variant alleles and differences in exposure to carcinogens. However, determination of CYP2C9 phenotypes in a larger group of subjects might clarify these slight differences.
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