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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Effects of calmidazolium, carbachol and derivatives of cyclic GMP on the longitudinal internal resistivity in rabbit atrial trabeculae

100%
Tuganowski W.
Journal of Physiology and Pharmacology
|
1991
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tom 42
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nr 4
The effects of calmidazolium, carbachol and membrane permeable derivatives of cGMP (dipalmitoyl cGMP and 8-Bromo cGMP) on the longitudinal internal resistivity (Ri) were studied in the rabbit atiial trabeculae by means of electrophysiological recording techniques and histological planimetry. Calmidazolium as well as carbachol decreased Ri whereas cGMP-derivatives enhanced this resistivity. The effect of calmidazolium suggested that calmodulin reduced the cell coupling under control conditions. Carbachol decreased the Ca-inward current, and probably it prevented the calmodulin activation. The action of the nucleotides showed that cGMP did not mediate the cholinergic effect on the cell coupling. The possible interaction between calmodulin and cGMP was discussed.
2
Content available remote

Effect of constitutive- and inducible-cyclooxygenase in the carbachol-induced pituitary-adrenocortical response during social stress

100%
Bugajski J., Gadek-Michalska A., Bugajski A. J.
Journal of Physiology and Pharmacology
|
2002
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tom 53
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nr 3
Acetylcholine potently stimulates the hypothalamic-pituitary-adrenal (HPA) axis. Cholinergic receptor agonist carbachol, given intraperitoneally (i.p.) or into the lateral cerebral ventricle (i.c.v.) to non-anesthetized rats acts via multiple pathways to stimulate the HPA axis. The present study sought to determine 1) the functional selectivity of carbachol for cholinergic muscarinic and/or nicotinic receptors involved in the stimulation of HPA axis; 2) the involvement of prostaglandins (PGs) generated by constitutive and inducible cyclooxygenase (COX-1 and COX-2) in the carbachol-induced ACTH and corticosterone secretion in non-stressed rats and animals exposed to social crowding stress for 7 days (24 per a cage for 6). Carbachol was given i.c.v. or i.p. and cholinergic receptor antagonists or cyclooxygenase isoenzyme antagonists were given by the same routes 15 min earlier. One hour after the last injection trunk blood was taken for ACTH and corticosterone determinations. Atropine (0.1 µg i.c.v.), a cholinergic receptor antagonist, totally abolished the carbachol (2 µg i.c.v.)-induced ACTH and corticosterone secretion and mecamylamine (20 µg i.c.v.), a selective nicotinic receptor antagonist, did not affect this secretion. This finding indicates that carbachol functions as a selective central cholinergic muscarinic receptor agonist for the HPA axis stimulation. Crowding stress significantly diminished the carbachol (0.2 mg/kg i.p.)-induced plasma ACTH and corticosterone levels measured 1 hr after administration. Pretreatment with indomethacin (2 mg/kg i.p.), a non-selective cyclooxygenase inhibitor, significantly diminished the ACTH and corticosterone responses to carbachol (0.2 mg/kg i.p.) in control rats and moderately decreased these responses in stressed rats. Piroxicam (0.2 and 2.0 mg/kg i.p.), a COX-1 inhibitor, considerably impaired the carbachol-induced ACTH and corticosterone responses in control rats and markedly diminished these responses in stressed rats. A selective COX-2 blocker, compound NS-398 (0.2 and 2.0 mg/kg i.p.), substantially decreased the carbachol-induced hormones secretion in control rats but did not markedly alter this secretion in stressed rats. These results indicate that in the carbachol-induced HPA axis activation PGs generated by COX-1 are considerably and to a much greater extent involved than PGs generated by COX-2. Social stress markedly diminishes the mediation of PGs generated by COX-1 but PGs synthesized by COX-2 do not substantially participate in the carbachol-induced HPA response.
3
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Histaminergic components in carbachol -induced pituitary-adrenocortical activity

84%
Bugajski J., Gadek-Michalska A., Borycz J., Bugajski A. J., Glod R.
Journal of Physiology and Pharmacology
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1994
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tom 45
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nr 3
4

Cholinergic-GABAergic interaction in the production of EEG theta oscillations in rat hippocampal formation in vitro

84%
Golebiewski H., Eckersdorf B., Konopacki J.
Acta Neurobiologiae Experimentalis
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1996
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tom 56
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nr 1
5
Content available remote

The involvement of nitric oxide and prostaglandins in the cholinergic stimulation of hypothalamic-pituitary-adrenal response during crowding stress

84%
Bugajski A. J., Gadek-Michalska A., Bugajski J.
Journal of Physiology and Pharmacology
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2006
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tom 57
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nr 3
The aim of the present study was to determine the effect of social crowding stress and significance of nitric oxide (NO) and prostaglandins (PG) generated by constitutive and inducible nitric oxide synthase (NOS) and cyclooxygenase (COX) in the stimulation of hypothalamic-pituitary-adrenal (HPA) axis by cholinergic muscarinic receptor agonist carbachol. Inhibitors of neuronal NOS (nNOS) L-NNA, general NOS L-NAME and inducible NOS (iNOS) aminoguanidine, as well as inhibitors of COX-1, piroxicam, and COX-2, compound NS-398 were administered 15 min prior to carbachol to control or crowded rats (24 rats in cage for 7, during 3 and 7 days). In stressed rats L-NAME, L-NNA and aminoguanidine significantly intensified the carbachol-induced ACTH and corticosterone secretion, like in control rats. Piroxicam, markedly decreased the carbachol-induced ACTH and corticosterone response under either basal or stress conditions. Compound NS-398 did not markedly alter the carbachol-induced HPA response in control and stressed rats. Crowding stress (3 days) significantly impaired the i.c.v. prostaglandin E2-induced ACTH response. Corticotropin releasing hormone (CRH) receptor antagonists, alpha-helical CRH [9-14], given i.c.v. did not alter the PGE2-evoked corticosterone response in either control or stressed rats, indicating that hypothalamic CRH is not involved in the PGE2-induced central stimulation of HPA axis. In control rats L-NAME considerably enhanced, while L-arginine, a physiological NOS substrate, abolished the PGE2-induced ACTH and corticosterone response. In stressed rats this NOS blocker significantly increased and L-Arg reduced the stimulatory effect of PGE2 on ACTH and corticosterone secretion. The carbachol-induced corticosterone response was significantly increased by pretreatment with nNOS inhibitor L-NNA and was considerably reduced by indomethacin, a general COX inhibitor. Pretreatment with both antagonists left the carbachol-induced corticosterone level unchanged, suggesting an independent and reciprocal effect of NO and PG in the cholinergic stimulation of pituitary-adrenocortical response. These results indicate that in the stimulatory action of muscarinic agonist, carbachol, NO is an inhibitory transmitter under basal and crowding stress conditions. This psychosocial stress does not functionally affect the NOS/NO systems. Prostaglandins are involved in the cholinergic muscarinic-induced stimulation of HPA response to a significant extent in non-stressed rats. PGE2 may be involved in the carbachol-elicited HPA response under basal and stress conditions. Prostaglandins released in response to muscarinic stimulation did not evoke the hypothalamic CRH mediation. NO significantly impairs and PG stimulates the carbachol-induced HPA response in rats under basal and social stress conditions.
6

Reduced glutathione and protein-bound SH in organs of mice after acetylcholine, carbachol or nivalin administration

84%
Lach H., Srebro Z., Dziubek K., Wachna E.
Acta Biologica Cracoviensia. Series Zoologia
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1999
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tom 41
7

The effect of carbachol on the phase of free-running locomotor activity rhythm under constant darkness [DD] and constant light [LL] in mice

84%
Gaweda M.
Folia Biologica
|
1998
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tom 46
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nr 3-4
8
Content available remote

The aging heart: changes in the pharmacodynamic electrophysiological response to verapamil in aged rabbit hearts

67%
Salameh A., Dhein S., Fleischmann B., Grohe C., Hescheler J., Linz K. W., Meyer R.
Journal of Physiology and Pharmacology
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2010
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tom 61
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nr 2
The aim of this study was to investigate whether the L-type calcium current (ICa.L) may be altered in aged hearts and whether the classical calcium antagonist verapamil may exhibit altered pharmacological profile in aged hearts. We examined male New Zealand rabbits aged either 6 months or 26 months. To examine ICa.L whole-cell patch-clamp technique was performed on isolated cells. Moreover, activation-recovery intervals (ARI) of isolated hearts (Langendorff method) were assessed using an epicardial 256 channel mapping system. We found that the ICa.L density, normalised to the cell volume was significantly reduced (p<0.001). Maximum conductance was also significantly decreased (p=0.01) and steady state inactivation was shifted to more positive potentials in aged hearts (p<0.001). A slightly reduced effect of ß-adrenergic modulation of the ICa.L in aged hearts, and a significantly reduced effect of carbachol on isoprenaline-stimulated ICa.L in aged hearts was observed. L-type 1c subunit, SERCA2-ATPase and the Na+/Ca2+-exchanger expression were neither significantly different in atrial and ventricular tissues nor between young and old animals. Using the mapping system, isolated hearts were exposed to verapamil (0.005, 0.01, 0.02, 0.05 µM/L). While verapamil did not affect ARI in young hearts, in aged hearts ARI was concentration-dependently reduced and the negative inotropic effect of verapamil was significantly attenuated in aged hearts (p<0.05). From these results we conclude that there are distinct alterations in the electrophysiology of ICa.L (reduced maximum conductance, a shift of the steady state inactivation) in the aged heart which may influence the response to verapamil.
9
Content available remote

Muscarinic acetylcholine receptor subtype 4 is esssential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin

67%
Takeuchi K., Kita K., Takahashi K., Aihara E., Hayashi S.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 3
10

Cholinergic modulation of synaptic transmission in horizontal connections of rat motor cortex

67%
Hess G., Krawczyk R.
Acta Neurobiologiae Experimentalis
|
1996
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tom 56
|
nr 4
11
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Social stress adapts signalling pathways involved in stimulation of the hypothalamic-pituitary-adrenal axis

67%
Bugajski J.
Journal of Physiology and Pharmacology
|
1999
|
tom 50
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nr 3
12
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Involvement of the central noradrenergic system in cholinergic stimulation of the pituitary-adrenal response

67%
Bugajski J., Borycz J., Gadek-Michalska A.
Journal of Physiology and Pharmacology
|
1998
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tom 49
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nr 2
13

Hippocampal rhythmic slow activity [RSA] in the cat after intraseptal injections of muscarinic cholinolytics

67%
Gralewicz S., Eckersdorf B., Golebiewski H.
Acta Neurobiologiae Experimentalis
|
1992
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tom 52
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nr 4
14

Age-related changes in muscarinic receptor and post-receptor mechanisms in brain and ileum strip of rats

67%
Michalek H., Fortuna S., Pintor A.
Acta Neurobiologiae Experimentalis
|
1993
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tom 53
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nr 1
15
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Phospholipase D mediated transphospatidylation as a possible new pathway of ethanol metabolism in isolated rat pancreatic acini

67%
Rydzewska G., Jurkowska G., Gabryelewicz A.
Journal of Physiology and Pharmacology
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1996
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tom 47
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nr 2
16

The influence of adrenergic and cholinergic agents on the respiratory burst of human neutrophils from peripheral blood and synovial fluid

67%
Gajewski M., Gujski M., Ksiezopolska-Pietrzak K., Jozwicka M., Maslinski S.
Journal of Physiology and Pharmacology. Supplement
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1997
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tom 48
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nr 2
17

Enhanced responsiveness of rat cardiac myocytes to muscarinic cholinergic stimulation during chemically-induced hypoxia

67%
Gajewski M., Laskowska-Bozek H., Moutiris J. A., Maslinski S., Ryzewski J.
Acta Neurobiologiae Experimentalis
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1993
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tom 53
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nr 1
18
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Mediation by nitric oxide of the carbachol-induced corticosterone secretion in rats

67%
Bugajski J., Borycz J., Gadek-Michalska A., Glod R., Bugajski A. J.
Journal of Physiology and Pharmacology
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1997
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tom 48
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nr 2
19

Behaviour - related effects of physostigmine on the rat visual evoked potential

67%
Bringmann A.
Acta Neurobiologiae Experimentalis
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1994
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tom 54
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nr 4
20

Epidermal growth factor signalling in rat pancreatic acinar cells

59%
Stryjek-Kaminska D.
Journal of Physiology and Pharmacology. Supplement
|
1998
|
tom 49
|
nr 1
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