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  1. 9 Archivum Immunologiae et Therapiae Experimentalis

  2. 5 Cellular and Molecular Biology Letters

  3. 3 Acta Biochimica Polonica

  4. 2 Folia Histochemica et Cytobiologica

  5. 2 Journal of Applied Genetics

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Autorzy help

  1. 2 Kusnierczyk H.

  2. 2 Radzikowski C.

  3. 2 Rak J.

  4. 2 Strzadala L.

  5. 1 Abuamara T. M. M.

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  1. 2 2021

  2. 1 2019

  3. 1 2018

  4. 2 2017

  5. 1 2016

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1

Nuclisome - a novel strategy for radionuclide cancer therapy

100%
Ickenstein L. M., Gedda L., Carlsson J., Sjoberg S., Edwards K.
Cellular and Molecular Biology Letters
|
2005
|
tom 10
|
nr Suppl.
2

Cyclin-dependent kinase inhibitor olomoucine II interacts with CDK2 and CDK9

100%
Krystof V., Orsag M., Paprskarova M., Muller P., Vojtesek B., Strnad M.
Cellular and Molecular Biology Letters
|
2005
|
tom 10
|
nr Suppl.2
3

Cancer stem cells: the theory and perspectives in cancer therapy

75%
Gil J., Stembalska A., Pesz K. A., Sasiadek M. M.
Journal of Applied Genetics
|
2008
|
tom 49
|
nr 2
193-199
The cancer stem cell theory elucidates not only the issue of tumour initiation and development, tumour’s ability to metastasise and reoccur, but also the ineffectiveness of conventional cancer therapy. This review examines stem cell properties, such as self-renewal, heterogeneity, and resistance to apoptosis. The ‘niche’ hypothesis is presented, and mechanisms of division, differentiation, self-renewal and signalling pathway regulation are explained. Epigenetic alterations and mutations of genes responsible for signal transmission may promote the formation of cancer stem cells. We also present the history of development of the cancer stem cell theory and discuss the experiments that led to the discovery and confirmation of the existence of cancer stem cells. Potential clinical applications are also considered, including therapeutic models aimed at selective elimination of cancer stem cells or induction of their proper differentiation.
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Nanoantibodies: small molecules, big possibilities

75%
Pedreanez A., Mosquera-Sulbaran J., Munoz N., Tene D., Robalino J.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2021
|
tom 102
|
nr 3
5

Combination of combretastatin A4 phosphate and doxorubicin-containing liposomes affetcs growth of B16-F10 tumors

75%
Mitrus I., Sochanik A., Cichon T., Szala S.
Acta Biochimica Polonica
|
2009
|
tom 56
|
nr 1
161-165
The study aimed to check the effectiveness of anticancer therapy combining a vascular-disruptive drug (combretastatin phosphate, CA4P) and a liposomal formulation of a chemotherapeutic (doxorubicin). CA4P was synthesized in our laboratory according to a previously described procedure. The antivascular drug and long-circulating doxorubicin-loaded liposomes were used to treat B16-F10 murine melanoma experimental tumors. Seventy-four hours after drug administration, a decrease in the number of tumor blood vessels was apparent and necrotic areas within tumors were visible. Combination therapy consisting of alternate administrations of CA4P and liposomal doxorubicin yielded greater inhibition of tumor growth than monotherapies alone. The best therapeutic results were obtained with the antivascular drug administered intratumorally every second day at 50 mg/kg body mass. In the case of combined therapy, the best results were obtained when the vascular-disruptive agent (CA4P) and the antineoplastic agent (liposomal doxorubicin) were administered in alternation.
6
Content available remote

Small molecule inhibitors of DNA-PK for tumor sensitization to anticancer therapy

75%
Pospisilova M., Seifrtova M., Rezacova M.
Journal of Physiology and Pharmacology
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2017
|
tom 68
|
nr 3
7

The intrabody targeting of hTERT attenuates the immortality of cancer cells

75%
Zhu X., Yang N., Cai J., Yang G., Liang S., Ren D.
Cellular and Molecular Biology Letters
|
2010
|
tom 15
|
nr 1
32-45
hTERT (human telomerase reverse transcriptase) plays a key role in the process of cell immortalization. Overexpression of hTERT has been implicated in 85% of malignant tumors and offers a specific target for cancer therapy. In this paper, we describe an effective approach using a single-chain variable fragment (scFv) intrabody derived from monoclonal hybridoma directed against hTERT to attenuate the immortalization of human uterine cervix and hepatoma cells. The scFv we constructed had a high affinity to hTERT, and specifically neutralized over 70% of telomere synthesis activity, thereby inhibiting the viability and proliferation of the cancer cells. Our results indicate that this anti-hTERT intrabody is a promising tool to target hTERT and intervene in the immortalization process of cancer cells.
8

Telomerase as a therapeutic target

75%
Huminiecki L.
Acta Biochimica Polonica
|
1996
|
tom 43
|
nr 3
Ribonucleoprotein telomerase is an enzyme that elongates telomeric DNA. In cells without detectable telomerase activity telomeres shorten with every cell generation and reaching critical length is a signal for cell death. Normal human somatic cells express undetectable, or low (bone marrow and peripheral leukocytes), telomerase activity. Reactivation of telomerase (immortalization) is probably necessary during development of a fully malignant cancer. Consequently, telomerase was proposed to be a therapeutic target for the cancer therapy. Potential results (including side-effects) of telomerase inhibition are being considered. After all, telomerase inhibition can be useful not only in the therapy, but also in cancer biology research, elucidating ageing and immortalization phenomena.
9

Regulatory T cell as a target for cancer therapy

63%
de Rezende L. C. D., Silva I. V., Rangel L. B. A., Guimaraes M. C. C.
Archivum Immunologiae et Therapiae Experimentalis
|
2010
|
tom 58
|
nr 3
179-190
10

Effect of hyperthermic shock on RNP structures in isolated RAT hepatocytes

63%
Orkisz S., Puvion E.
Folia Histochemica et Cytobiologica
|
1984
|
tom 22
|
nr 2
11

Transplantable mouse 16/C mammary adenocarcinoma as a model in experimental cancer therapy. II. Modification of tumor-host interactions by therapeutic procedures

63%
Rak J., Strzadala L., Kusnierczyk H., Radzikowski C.
Archivum Immunologiae et Therapiae Experimentalis
|
1989
|
tom 37
|
nr 3-4
12
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Anti-cancer effect of betulin and its derivatives, with particular emphasis on the treatment of melanoma

63%
Cabaj J., Bak W., Wroblewska-Luczka P.
Journal of Pre-Clinical and Clinical Research
|
2021
|
tom 15
|
nr 2
13

Transplantable mouse mammary adenocarcinoma 16/C as a model in experimental cancer therapy. III. Sensitivity to antitumor drugs

63%
Rak J., Kusnierczyk H., Strzadala L., Klosiewicz S., Radzikowski C.
Archivum Immunologiae et Therapiae Experimentalis
|
1989
|
tom 37
|
nr 3-4
14

In vitro evaluation of electroporated gold nanoparticles and extremely-low frequency electromagnetic field anticancer activity against Hep-2 laryngeal cancer cells

63%
Alshehri M. A., Wierzbicki P. M., Kaboo H. F., Nasr M. S. M., Amer M. E., Abuamara T. M. M., Badr D. A., Saleh K. A., Fazary A. E., Mohamed A. F.
Folia Histochemica et Cytobiologica
|
2019
|
tom 57
|
nr 4
15
Content available remote

Drug delivery systems improving chemical and physical properties of anticancer drugs currently investigated for treatment of solid tumors

63%
Aleksandrowicz R., Taciak B., Krol M.
Journal of Physiology and Pharmacology
|
2017
|
tom 68
|
nr 2
16

Cancer stem cells as targets for cancer therapy: selected cancers as examples

63%
Hombach-Klonisch S., Paranjothy T., Wiechec E., Pocar P., Mustafa T., Seifert A., Zahl C., Gerlach K. L., Biermann K., Steger K., Hoang-Vu C., Schulze-Osthoff K., Los M.
Archivum Immunologiae et Therapiae Experimentalis
|
2008
|
tom 56
|
nr 3
17

Biochemical and immunological characteristics of 4-1BB [CD137] receptor and ligand and potential applications in cancer therapy

63%
Sica G., Chen L.
Archivum Immunologiae et Therapiae Experimentalis
|
1999
|
tom 47
|
nr 5
18

Modulation of apoptosis signalling for cancer therapy

63%
Fulda S., Debatin K. M.
Archivum Immunologiae et Therapiae Experimentalis
|
2006
|
tom 54
|
nr 3
19

Tumor-associated macrophages as target for antitumor therapy

51%
Sawa-Wejksza K., Kandefer-Szerszen M.
Archivum Immunologiae et Therapiae Experimentalis
|
2018
|
tom 66
|
nr 2
20

Anticancer and antioxidant effects of fructooligosaccharide (FOS) on chemically-induced colon cancer in rats

51%
Moharib S. A.
Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine
|
2016
|
tom 19
|
nr 1
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