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1

Metabolic changes in rat brain synaptosomes after exposure to normobaric hyperoxia in vitro

100%
Gordon-Majszak W. L., Rafalowska U., Lazarewicz J. W.
Bulletin of the Polish Academy of Sciences. Biological Sciences
|
1987
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tom 35
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nr 4-6
2

Synaptosomal sodium pump activity depends on microfilament cytoskeleton integrity

100%
Nedvetsky P. I., Mongin A. A.
Acta Neurobiologiae Experimentalis
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1997
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tom 57
|
nr 3
3

Hyperoxia intensifies postischemic lipid peroxidation in gerbil brain synaptosomes

84%
Gordon-Majszak W. L., Lazarewicz J. W.
Bulletin of the Polish Academy of Sciences. Biological Sciences
|
1990
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tom 38
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nr 1-12
4
Content available remote

Age-related changes of Na plus, K plus - ATPase, Ca plus2 - ATPase and Mg plus2 - ATPase activities in rat brain synaptosomes

84%
Torlinska T., Grochowalska A.
Journal of Physiology and Pharmacology
|
2004
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tom 55
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nr 2
Cerebral metabolism of glucose, one of the determinants of tissue ATP level, is crucial for central nervous system function. The activity of P-type pumps, namely Na+, K+ - ATPase, Ca+2 - ATPase and Mg+2 - ATPase were examined in brain synaptosomes of 5 - day, 3 - month and 18 - month - old rats to determine if changes in enzyme activity related to aging are potentially associated with alterations in glucose homeostasis. Activities of all the ATPases studied in isolated brain synaptosomes were expressed in µmol of Pi liberated from ATP by 1 mg of synaptosome protein during one hour. Serum glucose concentration was measured by the glucose oxidase method and insulin level was estimated by the RIA. Our results demonstrate that 18 - month - old rats are characterized by hyperglycemia and hyperinsulinemia. Their serum glucose concentration was significantly increased approx. 62.3% and 135.8 % as compared to 3 - month - old rats and 5 - day, newborn rats, respectively. An enormous increase in serum insulin concentration in the old, hyperglycemic rats was observed concomitantly. As a result of these changes the insulin - to - glucose ratio in the old rats was greatly increased approx. (270% and 230%) compared to young, mature and newborn rats. Hyperglycemia and hyperinsulinemia occurring in the old rats, had a different impact on activities of the ATPases tested. Our results have revealed that Na+, K+ - ATPase activity remains almost unchanged with age, the activity of Ca+2 - ATPase decreases, whereas that of Mg+2 - ATPase increases significantly in old, insulin resistant rats. In conclusion it seems that changes in activity of different P - type pumps may differ with aging and that adaptation of specific ATPases to internal environment alterations is not identical.
5
Content available remote

In vivo and in vitro effects of hyperglycemia on Naplus-Kplus, Caplus2, Mgplus2-dependent ATPases activity in brain synaptosomes of aging rats

67%
Torlinska T., Grochowalska A., Kupisz J., Skoracka J., Kojo S.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 7
145-158
Cerebral metabolism of glucose, one of the determinants of tissue ATP level, is crucial for the CNS function. The activity of P-type pumps: Na+, K+-ATPase, Ca+2-ATPase and Mg+2-ATPase were examined in rat brain synaptosomes to determine if changes in the enzyme activity related to aging are potentially associated with alterations in glucose homeostasis. Male Wistar rats (newborn, 3- and 18-month-old) were sacrificed by decapitation and synaptic plasma membranes were isolated from brains. In vivo study demonstrated that 18-month-old rats were characterized by hyperglycemia, hyperinsulinemia and increased total antyoxidative status (TAS) level. These conditions had a different impact on activities of the ATPases tested in vivo: only the activity of Ca+2-ATPase decreased whereas that of Mg+2-ATPase increased significantly. In vitro experiments, prior incubation of isolated synaptosomes with glucose of concentrations corresponding to normoglycemia in vivo (4.5 - 6.5 mM), stimulated Ca+2-ATPase activity, whereas higher glucose concentrations (10.0 - 12.5 mM) inhibited significantly the enzyme activity. The most sensitive to hyperglycemia appeared Na+, K+-ATPase in old rats synaptosomes with the progressive decline starting at 6.5 mM glucose. The activity of Mg+2-ATPase was not inhibited in vitro even at high glucose concentrations that may explain the increased in vivo, activity of this enzyme in old, hyperglycemic rats.
6

Histamine and histidine effects on the transport of dopamine in the rat brain synaptosomes

67%
Waskiewicz J., Rafalowska U.
Bulletin of the Polish Academy of Sciences. Biological Sciences
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1992
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tom 40
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nr 2
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