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1
Content available remote

Increased gene expression of selected vesicular and glial glutamate transporters in the frontal cortex in rats exposed to voluntary wheel running

100%
Graban J., Hlavacova N., Jezova D.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 5
2
Content available remote

Effect of dehydroepiandrosterone (DHEA) on memory and brain derived neurotrophic factor (BDNF) in a rat model of vascular dementia

100%
Sakr H. F., Khalil K. I., Hussein A. M., Zaki M. S. A., Eid R. A., Alkhateeb M.
Journal of Physiology and Pharmacology
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2014
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tom 65
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nr 1
3
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Brain derived neurotrophic factor, a link of aerobic metabolism to neuroplasticity

100%
de Assis G. G., Gasanov E. V., de Sousa M. B. C., Kozacz A., Murawska-Cialowicz E.
Journal of Physiology and Pharmacology
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2018
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tom 69
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nr 3
4
Content available remote

The presence of tau protein in blood as a potential prognostic factor in stroke patients

84%
Lasek-Bal A., Jedrzejowska-Szypulka H., Rozycka J., Bal W., Kowalczyk A., Holecki M., Dulawa J., Lewin-Kowalik J.
Journal of Physiology and Pharmacology
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2016
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tom 67
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nr 5
5

The influence of BDNF on human umbilical cord blood stem/progenitor cells: Implications for stem cell-based therapy of neurodegenerative disorders

84%
Paczkowska E., Luczkowska K., Piecyk K., Roginska D., Pius-Sadowska E., Ustianowski P., Cesarska E., Dolegowska B., Celewicz Z., Machalinski B.
Acta Neurobiologiae Experimentalis
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2015
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tom 75
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nr 2
Umbilical cord blood (UCB)-derived stem/progenitor cells (SPCs) have demonstrated the potential to improve neurologic function in different experimental models. SPCs can survive after transplantation in the neural microenvironment and induce neuroprotection, endogenous neurogenesis by secreting a broad repertoire of trophic and immunomodulatory cytokines. In this study, the influence of brain-derived neurotrophic factor (BDNF) pre-treatment was comprehensively evaluated in a UCB-derived lineage-negative (Lin-) SPC population. UCB-derived Lin- cells were evaluated with respect to the expression of i) neuronal markers using immunofluorescence staining and ii) specific (TrkB) receptors for BDNF using flow cytometry. Next, after BDNF pre-treatment, Lin- cells were extensively assessed with respect to apoptosis using Western blotting and proliferation via BrdU incorporation. Furthermore, NT-3 expression levels in Lin- cells using RQ PCR and antioxidative enzyme activities were assessed. We demonstrated neuronal markers as well as TrkB expression in Lin- cells and the activation of the TrkB receptor by BDNF. BDNF pre-treatment diminished apoptosis in Lin- cells and influenced the proliferation of these cells. We observed significant changes in antioxidants as well as in the increased expression of NT-3 in Lin- cells following BDNF exposure. Complex global miRNA and mRNA profiling analyses using microarray technology and GSEA revealed the differential regulation of genes involved in the proliferation, gene expression, biosynthetic processes, translation, and protein targeting. Our results support the hypothesis that pre-treatment of stem/progenitor cells could be beneficial and may be used as an auxiliary strategy for improving the properties of SPCs.
6
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The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies

67%
Zoladz J. A., Pilc A.
Journal of Physiology and Pharmacology
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2010
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tom 61
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nr 5
It is well documented that physical activity can induce a number of various stimuli which are able to enhance the strength and endurance performance of muscles. Moreover, regular physical activity can preserve or delay the appearance of several metabolic disorders in the human body. Physical exercise is also known to enhance the mood and cognitive functions of active people, although the physiological backgrounds of these effects remain unclear. In recent years, since the pioneering study in the past showed that physical activity increases the expression of the brain derived neurothophic factor (BDNF) in the rat brain, a number of studies were undertaken in order to establish the link between that neurothrophin and post-exercise enhancement of mood and cognitive functions in humans. It was recently demonstrated that physical exercise can increase plasma and/or serum BDNF concentration in humans. It was also reported that physical exercise or electrical stimulation can increase the BDNF expression in the skeletal muscles. In the present review, we report the current state of research concerning the effect of a single bout of exercise and training on the BDNF expression in the brain, in both the working muscles as well as on its concentrations in the blood. We have concluded that there may be potential benefits of the exercise-induced enhancement of the BDNF expression and release in the brain as well as in the peripheral tissues, resulting in the improvement of the functioning of the body, although this effect, especially in humans, requires more research.
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