Wyniki wyszukiwania - AGRO

1

Acrylamide-induced changes of granulopoiesis in porcine bone marrow

100%

Grzybowska D., Snarska A.

Journal of Veterinary Research

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2021

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tom 65

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nr 3

2

Atypical cytomorphology of Gaucher cells is frequently seen in bone marrow smears from untreated patients with Gaucher disease type 1

100%

Markuszewska-Kuczynska A., Klimkowska M., Regenthal S., Bulanda A., Bjorkvall C. K., Machaczka M.

Folia Histochemica et Cytobiologica

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2015

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tom 53

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nr 1

3

Successful mafosfamide purging of bone marrow from chronic myelogenous leukemia [CML] cells

100%

Nieborowska-Skorska M., Skorski T., Ratajczak M. Z., Szczylik C., Malaguarnera L., Calabretta B.

Folia Histochemica et Cytobiologica

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1993

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tom 31

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nr 4

4

Expression of metallothionein [MT] and glutathione s-transferase pi [SGTP] in the bone marrow of patients with myeloproliferative disorders [MPD]

100%

Wrobel T., Mazur G., Dziegiel P., Surowiak P., Kuliczkowski K., Zabel M.

Folia Morphologica

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2004

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tom 63

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nr 1

Overexpression of SGTP and/or MT may contribute to various carcinogenic processes and to resistance to anticancer treatment. The importance of these proteins, although clearly established in solid tumours, has not been fully understood in haematopoietic neoplasm. The aim of this study was to determine the expression of MT and SGTP in the bone marrow of patients with MPD. Twenty paraffin-embedded bone marrow core biopsy specimens from newly diagnosed patients with MPD were evaluated — osteomyelofibrosis (OMF), n = 9 and chronic myelocytic leukaemia (CML), n = 11. We demonstrate increased SGTP and MT expression in the bone marrow of MPD patients. In our study levels of MT in OMF patients were higher than in CML. This suggests that MT expression may correlate with bone marrow fibrosis. These data, although based on a relatively small number of patients, raise the possibility that SGTP and MT may play a role in the pathogenesis of MPD. The clinical significance of this phenomenon needs further investigation.

5

Interferon alpha in the treatment of chronic myelogenous leukemia

100%

Robak T.

Archivum Immunologiae et Therapiae Experimentalis

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1998

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tom 46

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nr 6

6

Endothelial progenitor cells as a new agent contributing to vascular repair

100%

Miller-Kasprzak E., Jagodzinski P. P.

Archivum Immunologiae et Therapiae Experimentalis

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2007

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tom 55

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nr 4

7

Transplantation of autologous bone marrow stromal cells (BMSC) for ischemic stroke - strategy and tactics for clinical application

86%

Kuroda S.

Acta Neurobiologiae Experimentalis

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2013

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tom 73

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nr 1

Objective: There is increasing evidence that the transplanted bone marrow stromal cells (BMSC) significantly promote functional recovery after central nervous system damage in the animal models of various kinds of CNS disorders, including cerebral infarct. However, there are several shortages of information when considering clinical application of BMSC transplantation for patients with neurological disorders. In this meeting, therefore, we discuss what we should clarify to establish cell transplantation therapy in clinical situation and describe our recent works for this purpose. Methods and Results: The BMSC have multiple abilities to differentiate into the neural cells and to promote neuronal survival and axon elongation, contributing to rebuild the neural circuits in the injured CNS. Using optical imaging and MRI techniques, the transplanted BMSC can non-invasively be tracked in the living animals for at least 8 weeks after transplantation. Clinical MR apparatus can visualize the tagged BMSC in the brain. FDG PET is quite valuable to monitor the recovery of brain metabolism after transplantation. The BMSC can be expanded using the animal protein-free culture medium within a clinically relevant period. G-CSF is useful to enhance their proliferation when the BMSC are obtained from the aged patients. There are optimal dose and timing of BMSC transplantation to yield significant therapeutic benefits. Conclusion: It is urgent issues to develop clinical imaging technique to track the transplanted cells in the CNS and evaluate the therapeutic significance of BMSC transplantation to establish it as a definite therapeutic strategy in clinical situation in very near future.

8

Bone marrow transplantation in Polish conditions. Method for removal of red cells from the transplant in the case of major blood group incompatibility

86%

Wiktor-Jedrzejczak W., Ratajczak M. Z., Szczylik C.

Archivum Immunologiae et Therapiae Experimentalis

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1989

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tom 37

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nr 3-4

9

The influence of high and low doses of acrylamide on porcine erythropoiesis

86%

Snarska A., Palus K., Wysocka D., Rytel L.

Journal of Veterinary Research

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2020

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tom 64

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nr 4

10

The expression of the SLIT–ROBO family in adult patients with acute myeloid leukemia

86%

Golos A., Jesionek‑Kupnicka D., Gil L., Braun M., Komarnicki M., Robak T., Wierzbowska A.

Archivum Immunologiae et Therapiae Experimentalis

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2019

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tom 67

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nr 2

11

86%

Barcew K., Kacinska E., Marchlewicz M., Wiszniewska B., Machalinski B.

Folia Morphologica

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2004

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tom 63

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nr 1

The aim of the work was to examine the morphology of the bone marrow of mice during stimulation with G-CSF. Experimental Balb C mice were daily injected subcutaneously with 250 μg/kg b.w. G-CSF (Neupogen). After 2, 4 and 6 days of the experiment femurs were obtained for morphological study. On day 2 of the mobilization the amount of haematopoietic cells in the bone marrow increased and dilatation of the sinusoids was observed. Only single leukocytes were observed in the lumen of the vessels. There were numerous leukocytes in the lumen of the sinusoids on day 4 of the mobilization. The morphology of the bone marrow on day 6 was similar to that of the control. Mobilization of mice with G-CSF resulted in migration of haematopoietic cells from the bone marrow and the process is most pronounced on day 4.

19

The influence of chemotherapy on bone marrow in patients with chronic lymphocytic leukaemia

86%

Lemancewicz D., Dzieciol J., Kloczko J., Piszcz J.

Folia Morphologica

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2004

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tom 63

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nr 4

In chronic lymphocytic leukaemia (CLL) bone marrow trephine biopsy (BMT) is not required for diagnosis but can have a significant prognostic value and can be used for the detection of the minimal residual disease (MRD) and for assessment of the effectiveness of the treatment applied. The aim of the study was to evaluate the morphological changes in bone marrow after treatment with purine nucleoside analogues cladribine and fludarabine. Bone marrow trephine biopsy was taken routinely from 15 patients with CLL. Bone marrow trephine biopsy was performed on every patient before as well as after chemotherapy. The number of cell elements of the marrow (the degree of atrophy), the patterns of bone marrow infiltration, the presence of reticulin and collagen fibres and the disturbances in bone marrow stroma were assessed. The infiltration of bone marrow by neoplastic cells was observed in all the patients before administration of chemotherapy. The infiltration was followed by an increase in the number of reticulin fibres. After the treatment a regression of the reticulin fibres was observed with the lessening of the infiltration. After the treatment the levels of marrow infiltrate were decreased. Increased hypoplasia of the bone marrow was observed after the chemotherapy.

20

Induction of micronuclei in rat bone marrow after subchronic inhalation exposure to mixture of benzene, cyclohexanone and cyclohexane

86%

Kovalkovicova N., Sutiakova I., Legath J., Legath L., Falis M., Pistl J., Kovac G.

Bulletin of the Veterinary Institute in Puławy

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2004

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tom 48

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nr 3

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