Wyniki wyszukiwania

1

Modelling the state of bone cysts by statistical analysis of intensities of X-ray images

100%

Brecelj J., Bole V.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr 2

The subject of this article is the state of a benign bone disease. The principle aim of this study is the construction of a statistical model for estimating the otherwise unobservable variable for the state of the disease. The distribution of intensity of X-ray images of the affected part and the healthy part of the bone are evaluated. Quantiles of both distributions are used in the estimation of a multinomial logit model by which the variable for the state of the disease is quantified.

2

Lansoprazole is an uncompetitive inhibitor of tissue-nonspecific alkaline phosphatase

84%

Delomenede M., Buchet R., Mebarek S.

Acta Biochimica Polonica

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2009

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tom 56

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nr 2

301-305

Lansoprazole, a known H+/K+-ATPase inhibitor, is currently used as a therapeutical option for the initial treatment of gastroesophageal reflux disease. Recently, lansoprazole has been found to be an inhibitor of cytosolic PHOSPHO1 (a phosphatase which hydrolyses phosphocholine and phosphoethanolamine), providing a possible therapeutical target to cure pathological mineralization. Since PHOSPHO1 is present inside matrix vesicles, we tested the effect of lansoprazole on matrix vesicles containing several key enzymes for the mineralization process including tissue-nonspecific alkaline phosphatase. We found that lansoprazole can inhibit in an uncompetitive manner tissue-nonspecific alkaline phosphatase. A Ki value of 1.74 ± 0.12 mM has been determined for the inhibition of tissue-nonspecific alkaline phosphatase by lansoprazole. Lansoprazole, currently used for treating gastroesophageal disease, by inhibiting PHOSPHO1 and tissue-nonspecific alkaline phosphatase could prevent hydroxyapatite-deposition disease and could serve as an adjunct treatment for osteoarthritis.

3

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Prevalence of skeletal fluorosis in fishermen from Kutch coast, Gujarat, India

84%

John J., Hariharan M., Remy V., Haleem S., Thajuraj P. K., Deepak B., Rajeev K. G., Divakar D. D.

Roczniki Państwowego Zakładu Higieny

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2015

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tom 66

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nr 4

Background. In health terms, consuming fluoride is well recognised to be a double-edged sword. Consumption of optimal amounts is beneficial to health, however an excess constitutes a health hazard. Objectives. To assess the prevalence of skeletal fluorosis in fishermen from the Kutch coast, Gujarat, India. Materials and method. A descriptive cross-sectional survey was conducted on 653 fishermen from the Kutch District, Gujarat, India, from October 2014 to December 2014. Clinical skeletal fluorosis was assessed using three diagnostic tests. Drinking water fluoride concentrations in different regions of the study area were determined. General information regarding age, gender and adverse habits were also collected. The Chi square test was used for comparisons and the confidence level and critical p-value were set at 95% and 5% respectively. Results. Fluoride concentrations in water from the study area ranged between 3.4- 6.9 ppm. The prevalence of skeletal fluorosis was 30.3%, out of which, the majority of the subjects had mild skeletal fluorosis (18.4%). This condition was found to be significantly associated with age and gender along with tobacco and alcohol consumption; depending on the habit’s duration. Conclusion. Being a public health problem in the fishermen community, skeletal fluorosis requires a-priori attention. Measures for preventing this disease should be undertaken on a communitywide basis.

4

Fragmented coronary process as an element of elbow dysplasia. Balance of two years of experience

84%

Biezynski J., Skrzypczak P., Kosciolek N., Piatek A., Drozdzynska M.

Bulletin of the Veterinary Institute in Puławy

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2010

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tom 54

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nr 3

This article aims to compare the treatment of fragmented coronary process in the context of clinical results. Forty-two dogs of both sexes, aged from 5 months to 2 years, all belonging to the predisposed breeds, were tested. Each patient was subjected to radiological and clinical examination on the basis of which was classified into one of four degrees of dysplasia according to criteria of the International Elbow Working Group. Then the decision towards specific therapeutic procedures, operational or pharmacological, was taken. About 4-12 weeks after the surgery, the control examination was performed. It allowed to assess the post-surgery mobility. The results depended on the age of animal at which treatment was carried out, and the degree of degenerative changes in the joint. The studies have shown that the best results were obtained in a group of dogs aged 5-9 months, in whom a dynamic ulna osteotomy was performed. This indicates the need for early diagnosis of disease and rapid implementation of the treatment, to eradicate the problem of radial- ulnar incongruity, thereby preventing the development of further changes within the joint.

5

Plasma level of protein C, fibrinogen concentration, and platelet number in dogs with Leg-Calve-Perthes disease and osteochondrosis. Preliminary studies

84%

Szponder T., Wessely-Szponder J.

Bulletin of the Veterinary Institute in Puławy

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2010

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tom 54

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nr 3

The possible role of coagulatory disorders in pathogenesis of Legg-Calve-Perthes disease (Lepo) and osteochondrosis (OC) was examined. A decrease in protein C level in dogs with LCPD (94.31±4.74%) in comparison with healthy dogs (95.8±6.35%) was observed. Moreover, in OC affected animals, the value varied between 92.25±2.5% and 94.33±5.5%. The mean plasma fibrinogen level in control group was 2.69±0.65 mg/mL, whereas in OC groups significantly higher values were found. Platelets number varied between individuals but was within normal range in all groups. Taking into account a decrease in protein C plasma level and an increase in fibrinogen concentration, the relationship between developmental diseases and coagulation disorders was revealed in dogs.

6

Osteoporosis risk factors in rural and urban women from the Lublin Region of Poland

84%

Filip R. S., Zagorski J.

Annals of Agricultural and Environmental Medicine

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2005

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tom 12

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nr 1

In various epidemiological and clinical studies, bone quality, bone mineral density (BMD), as well as risk of falling have been associated with lifestyle and anthropometric/demographic characteristics. The objective of this study was to evaluate the osteoporosis risk factors occurrence and its association with BMD in rural and urban women from the Lublin Region in Poland. A cross-sectional study of risk factors of osteoporosis and fracture was carried out in a cohort of 900 rural and urban women aged 30-79 years, representative of the general population the Lublin Region. Data pertaining to osteoporosis risk factors as well as medical history were taken using a specially designed 31 item questionnaire divided in seven sections: social history, past medical history, reproductive history, drug history, family history of osteoporosis, nutritional habits and lifestyle factors. The lumbar spine (L2-L4) was examined in a-p position using the dual X-ray absorptiometry- DXA (LUNAR Corp.). The differences between urban and rural women in the appearance of particular osteoporosis risk factors, such as gynecological, dietary calcium intake, smoking and coffee consumption, was noticeable. Age, years of menopause and family history of osteoporosis (in mothers) were found to have strong negative independent associations with lumbar spine BMD. Body Mass Index (BMI) was found to have strong positive association with BMD. Dietary calcium intake, coffee consumption and level of physical activity had noticeable positive and independent, but not significant association with BMD.

7

Mutations in type I collagen genes resulting in osteogenesis imperfecta in humans

84%

Gajko-Galicka A.

Acta Biochimica Polonica

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2002

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tom 49

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nr 2

Osteogenesis imperfecta (OI), commonly known as "brittle bone disease", is a dominant autosomal disorder characterized by bone fragility and abnormalities of connective tissue. Biochemical and molecular genetic studies have shown that the vast majority of affected individuals have mutations in either the COL1A1 or COL1A2 genes that encode the chains of type I procollagen. OI is associated with a wide spectrum of phe- notypes varying from mild to severe and lethal conditions. The mild forms are usually caused by mutations which inactivate one allele of COL1A1 gene and result in a reduced amount of normal type I collagen, while the severe and lethal forms result from dominant negative mutations in COL1A1 or COL1A2 which produce structural defects in the collagen molecule. The most common mutations are substitutions of glycine residues, which are crucial to formation and function of the collagen triple helix, by larger amino acids. Although type I collagen is the major structural protein of both bone and skin, the mutations in type I collagen genes cause a bone disease. Some reports showed that the mutant collagen can be expressed differently in bone and in skin. Since most mutations identified in OI are dominant negative, the gene therapy requires a fundamentally different approach from that used for genetic-recessive disorders. The antisense therapy, by reducing the expression of mutant genes, is able to change a structural mutation into a null mutation, and thus convert severe forms of the disease into mild OI type I.

8

Health promotion and health education with particular emphasis on bone diseases among rural population in Poland

84%

Filip R. S., Bylina J., Zagorski J.

Annals of Agricultural and Environmental Medicine

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2006

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tom 13

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nr 1

Osteoporosis and osteoarthrosis are the most common diseases of bone tissue affecting both rural and urban populations. The aim of the study was to investigate the level of education and requirement for health promotion within the scope of common diseases of the skeletal system among rural population in Poland. This was an exploratory study with a cross-sectional design performed between May 2004–September 2005 in rural areas of 16 Voivodeships (main provinces) of Poland. The study population comprised of 404 (62.9%) rural women and 238 (37.1%) rural men (total 642). All subjects were randomly sampled and recruited by personal contact in primary health care centres. Study data were obtained using a specially prepared questionnaire. The most commonly reported diseases were: arterial hypertension (26.1%), joint degenerative disease (24.6%) and osteoarthritis (14.7%). The occurrence of osteoarthritis and joint degenerative disease increased with age and was highest in the group aged over 50 (21% and 38.7% respectively). Osteoarthitis was more frequent in women compared to men (16% and 12.2% respectively). In most cases, the basic information about methods of prevention and treatment given by a General Practitioner or a specialist was characterized as “satisfactory” (73.6% and 62.9% respectively). The most popular prophylactic action performed in local communities was bone densitometry (14.1%), and the most important source of knowledge - TV and radio (65%). Populations living in rural areas have limited access to health education and health prophylaxis actions, irrespective of the geographical region of Poland. Inhabitants with secondary or higher education, as well as those with a higher household income, have better knowledge about skeletal system diseases compared to those with a lower educational level. The practical implications of this study suggest the necessity for paying more attention to etiology, symptoms and methods of prevention and treatment of bone diseases when attending to patients in specialist practice.

9

Interleukin-6 is not essential for bone turnover in hypothyroid mice

67%

Mysliwiec J., Zbucki R., Winnicka M. M., Sawicki B., Nikolajuk A., Kaminski K., Mysliwiec P., Musial W., Bondyra Z., Walecki J., Gorska M.

Folia Histochemica et Cytobiologica

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2007

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tom 45

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nr 4

387-392

10

Bone as a source of organism vitality and regeneration

67%

Mackiewicz Z., Niklinska W. E., Kowalewska J., Chyczewski L.

Folia Histochemica et Cytobiologica

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2011

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tom 49

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nr 4

11

Mleko i przetwory mleczne chronia przed osteoporoza

51%

Debinski A., Sawicki A.

Żywność, Żywienie a Zdrowie

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1997

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tom 06

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nr 1

81-84

Ograniczanie wyników

Modelling the state of bone cysts by statistical analysis of intensities of X-ray images

Lansoprazole is an uncompetitive inhibitor of tissue-nonspecific alkaline phosphatase

Prevalence of skeletal fluorosis in fishermen from Kutch coast, Gujarat, India

Fragmented coronary process as an element of elbow dysplasia. Balance of two years of experience

Plasma level of protein C, fibrinogen concentration, and platelet number in dogs with Leg-Calve-Perthes disease and osteochondrosis. Preliminary studies

Osteoporosis risk factors in rural and urban women from the Lublin Region of Poland

Mutations in type I collagen genes resulting in osteogenesis imperfecta in humans

Health promotion and health education with particular emphasis on bone diseases among rural population in Poland

Interleukin-6 is not essential for bone turnover in hypothyroid mice

Bone as a source of organism vitality and regeneration

Mleko i przetwory mleczne chronia przed osteoporoza