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Periods of no activity between 02.00 and 10.00 and lasting for up to 7 h 40 min are reported for two captive Crocidura flavescens (I. Geoffroy, 1827). During one of these periods, the weight specific energy requirement of the shrew dropped to 25.1% of the usual, indicating a period of spontaneous torpor. Nest-box temperatures also drop during the periods of prolonged inactivity suggesting a lowered body temperature. Data for a younger animal suggest shorter periods of torpor. The timing of the torpor spans the coldest period of the day when the animal would expend most energy maintaining a constant body temperature.
Grucza R. and Hänninen O.: Importance of dynamics of sweating in men during exercise. Acta Physiol. Pol. Influence of dynamics of sweating on rectal temperature increase was tested in 3 groups of men performing cycle exercise with intensity of 65, 90 and 120 W, respectively, in 22°C chamber temperature and 30% of relative air humidity. During exercise at 65 and 90 W the subjects wore suits while exercising with intensity of 120 W they wore only shorts. The dynamics of sweating was described by delay in onset of sweating and time constant of the reaction. Wearing caused significant increase in skin humidity and decreased evaporative rate of sweating. Sweat rate during steady state was related to the metabolic rate in naked (r = 0.89, p < 0.002) as well as in wearing subjects (r = 0.93, p < 0.01). Delay in onset of sweating was, in average, 5 min with a time constant of 7 min. Both factors showed a tendency to be shorter with increasing work intensity. Mean increase in rectal temperature was proportional to the intensity of exercise although the individual ATre correlated well with the dynamics of sweating in naked (r = 0.83, p < 0.01) and wearing subjects (r = 0.84, p < 0.01). Since ΔTre was smaller in subjects with shorter inertia time of sweating in response to beginning of exercise at the same intensity it is concluded that the dynamics of sweating can play an important role in limiting body temperature increase in working men.
Ectothermal vertebrates regulate their body temperature within definite limits to maintain physiological processes at their optimal levels. Among others, food processing and absorption are strongly temperature-dependent. Deficiency of adequate temperatures limits ectotherms in growth and maintenance. On the other hand, thermoregulatory behavior is costly and should be constrained by many factors. Using artificial thermal gradients (26–44℃ ), we measured temperature preferences of 10 spiny-tailed agamas (Uromastyx acanthinura) in controlled indoor experiment. Each lizard could choose place in the terrarium before and after feeding. Then, temperature preferences during pre-feeding and post-feeding periods were compared. We found significant increase of preferred temperature after feeding. Detailed view revealed that there is consistent influence of body size: bigger lizards maintained higher temperature during the whole experiment. We hypothesize that bigger potential predation risk on smaller lizards due to their size would force them to choose less optimal conditions.
Applications of continuous body temperature measurements in pigs – a review.The temperature measurement is one of the most important indices in estimating the state of health both in humans and animals. Nowadays along with the development of technical knowledge and its implementation, increasingly more attention is paid to the continuously measurement of body temperature. This solution seems to be especially needed for the animal production.Continuous body temperature measurementsprovide a better control of the herd and a precise determination of the environmental impact on animal. Moreoverthis measurement may be very useful method in different animal studies enabling to obtain a large amount of data. The aim of this paper is to review the current state of knowledge on the topic of the most widely used methods of continuous body temperature measurement in pigs and also to show the directions of studies for the future.
This is a review of thermal imaging methods used for the measurement of body surface temperatures, including the most important medical applications, papers on thermal maps of people with various body compositions, and the applicability of thermal imaging in sport training.
Kruk. В., Szczypaczewska M., Opaszowski В., Kaciuba Uściłko H., Nazar K. Thermoregulatory and metabolic responses to repeated bouts of prolonged cycle-ergometer exercise in man. Acta Physiol. Pol., Changes in body temperature, oxygen uptake (VO₂ ), heart rate (HR), sweating rate and plasma osmolality were examined in 10 human subjects, performing four successive 30 min exercise-bouts of the same intensity (50% VO₂ max) separated by 30 min rest periods. In spite of the rest intervals and replacement of body fluid loss there was a progressive increase in VO₂ . HR, rectal (Tre) and mean body (Tb) temperatures in consecutive exercise bouts. The thermoregulatory efficiency showed an increasing tendency, and a delay in the sweating response at the beginning of each exercise was shortened. It is concluded that a drift in metabolic and temperature responses to exercise, reported throughout a long-term continuous work, occurs also in the euhydrated subjects performing a prolonged intermittent exercise. It is not caused by an impaired thermoregulation during exercise but rather by insufficient restitution of metabolic processes during rest intervals.
A large body of evidence has implicated prostaglandin E2 (PGE2) in fever production. However, the role of PGD2 in this context is only poorly understood. We therefore determined by LC-MS/MS analyses the content of PGD2 and PGE2 in cerebrospinal fluid (CSF), plasma and lungs of rats over 5 hours after fever induction by intraperitoneal injection of lipopolysaccharide (LPS, 50 µg/kg). Both PGD2 and PGE2 were detected in CSF, plasma and lungs of saline-treated control animals. The injection of LPS evoked fever and an increase of PGE2 in the CSF, while the CSF content of PGD2 was not significantly altered. However, both PGE2 and PGD2 levels were elevated in plasma and lungs after LPS injection. Interestingly, pretreatment with a novel selective inhibitor of hematopoietic prostaglandin D synthase (H-PGDS), EDJ300520 (10-40 mg/kg p.o.), selectively and dose-dependently prevented the LPS-induced increase of PGD2 in plasma and lungs but did not affect the PGE2 content. Most remarkably, EDJ300520 pretreatment led to an hypothermic response after LPS injection during the first 3 h and prevented fever induction. These data indicate that PGD2 produced peripherally by H-PGDS essentially contributes to LPS-induced fever.
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Role of prostaglandins in heme-induced fever

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Brain stroke is often accompanied by a high fever, which is insensitive to a blockade with classic antipyretic drugs known to inhibit the synthesis of prostaglandin E2 (PGE2), a proximal mediator of fever associated with infection. The molecular mechanism of fever associated with stroke is mostly unknown, and has not been thoroughly investigated. One characteristics of the stroke is an extravasation of the erythrocytes into the brain tissue followed by a release of hemoglobin and free heme. In the present study we have tested the hypothesis that free heme itself can induce fever after releasing into the brain. The study was conducted on Sprague Dawley rats instrumented with biotelemetry devices to monitor deep body temperature, and implanted with brain cannulae projected to the lateral ventricle. We demonstrate that heme-L-lysinate microinfused intraventricularly (icv) induces a dose-dependent fever lasting ca. 8 hours. Injection of heme-L-lysinate provoked a significant elevation of PGE2 in the rat cerebro-spinal fluid collected 3 hours post-injection. The fever induced by heme-L-lysinate was blocked by an icv injection of anti- PGE2 antibody. It was not affected, however, by intraperitoneal administration of indomethacin, a cyclooxygenase inhibitor. We conclude that heme-induced fever may underlie the stroke fever.
This paper presents the first recorded measures of resting metabolic rate and body temperature in the tenrec Limnogale mergulus Major, 1896. The preliminary results suggest that, although this is the only aquatic species within the family Tenrecidae, it does not maintain either resting metabolic rate or body temperature at an elevated level. Further studies of this rare, aquatic insectivore are recommended.
Nitric oxide (NO) has been shown to be an important mediator of febrile response to lipopolisaccharide (LPS). To clarify the role of different isoforms of NO synthase (NOS) in febrile response to immune challenge, effects of selective iNOS and nNOS inhibitors on fever to LPS were examined in freely moving biotelemetered rats. Vinyl-L-NIO (N5 - (1-Imino-3-butenyl) - ornithine (vL-NIO), a neuronal nitric oxide synthase (nNOS) inhibitor, and aminoguanidine hydrochloride, an inducible nitric oxide synthase (iNOS) inhibitor, were injected intracerebroventricularly at a dose of 10 µg/rat just before intraperitoneal injection of LPS at a dose of 50 µg/kg. Both inhibitors injected at a selected doses had no effect on normal day-time body temperature (Tb) and normal night-time Tb. vinyl-L-NIO and aminoguanidine injected intracerebroventricularly at a dose of 10 µg/animal suppressed the LPS-induced fever in rats. The fever index calculated for rats pretreated with v-LNIO or with aminoguanidine and injected with LPS was reduced by 43% and 72%, respectively, compared to that calculated for water-pretreated and LPS-injected rats. Whereas vL-NIO partly attenuated both phases of febrile rise in Tb, administration of aminoguanidine into the brain completely prevented fever induced by LPS. These data indicate that activation of iNOS inside the brain is not only responsible for triggering but also for maintaining of LPS-induced fever in rats. It is, therefore, reasonable to hypothesize that, activation of iNOS inside the brain is more important in fever development than activation of nNOS.
The purpose of this study was to investigate the role of neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS) in the brain during development of fever in response to localized tissue inflammation caused by injection of turpentine in freely moving biotelemetered rats. To determine the role of both NOSs in turpentine-induced fever, we injected vinyl-L-NIO (N5 – (1-Imino-3-butenyl) – ornithine (vL-NIO), a selective nNOS inhibitor, and aminoguanidine hydrochloride, a selective iNOS inhibitor, intracerebroventricularly (i.c.v.) 5 h after turpentine injection. Rats responded with fever to intramuscular injection of 20 µl of turpentine that commenced about 5 - 6 h after injection and reached peak value between 9 - 11 h post-turpentine. The inhibition of nNOS as well as iNOS in the brain did not affect fever induced by turpentine. Fevers in control rats (treated i.c.v. with pyrogen-free water) and iNOS or nNOS inhibitor-i.c.v. treated rats injected with turpentine were essentially the same. Furthermore, on the basis of these data, we concluded that iNOS and nNOS inside the brain do not participate in generation of fever to turpentine in rats.
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