Ograniczanie wyników

Czasopisma help
Autorzy help
Lata help
Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 382

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 20 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  biosynteza
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 20 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
The synthesis of estrogens from androgens is catalyzed by an enzyme complex called aromatase, and therefore has a unique potential to influence the physiological balance between the sex steroid hormones. This enzyme complex consists of two components: aromatase cytochrome P450 and NADPH-cytochrome P450 reductase. Aromatase is conserved amongst all vertebrates and mammals in particular. It is a member of the cytochrome P450 super-family of enzymes. Within this, aromatase cytochrome P450 is presently the sole member of family 19, and is encoded by the gene known as CYP19 which contains a number of tissue-specific promoters that direct aromatase expression in different tissues via alternative splicing. A number of tissues in mammals have the capacity to express aromatase. These include the ovaries and testes, the placenta, adipose tissue, osteoblasts of bone, vasculature smooth muscle, and numerous sites in the brain.
The effect of different levels of inorganic nitrogen sources (0.15,0.21 and 0.25% nitrogen content) on the synthesis of cellulase-free ß-1,4-xylanase by Aureobasidium pullulans DSM-73015 was examined. Among inorganic nitrogen compounds tested, ammonium nitrate (NH4NO3) was the best inorganic nitrogen source at 0.21% nitrogen content that gave the highest volumetric and specific activities (8830.09 nkat mL-1; 10767.15 nkat/mg protein) after 96 h of cultivation, while urea displayed the lowest effect. Partial characterization of this crude enzyme produced after optimization processes on two different buffer systems showed that its optimum pH activity was 4, while the thermoactivity had its maximum at 50°C in both buffers. The highest volumetric and specific activities obtained were 20102.35 nkat mL-1; 23000.40 nkat/mg protein for sodium acetate buffer and 19852.30 nkat mL-1; 22714.31 nkat/mg protein for sodium citrate buffer.
The strain Aureobasidium pullulans A.p.-3 was subjected to mutagenesis to improve its ability to pullulan biosynthesis. The mutagenesis of 18-h old culture was carried out in two variants using ethylen imine (EI) and ultraviolet (UV) radiation at the EI concentration and UV exposure times of 2.0 mg/mL and 1.5 min (variant I), and 2.0 mg/mL and 2.0 min (variant II). Among 240 cultures examined, the positive mutants made 26% for variant I and 13% for variant II. Two best black mutants Dy-17 and Dx-30 synthesized the polysaccharide with the yields greater than those of parent strain by 24 and 21%, respectively. White mutant was also obtained, the pullulan yield for which was on the level as for strain A.p.-3, but free from melanin contaminants. Acquired characteristic of black mutants was found stable when re-examined after 3- and 6-month storage at 4°C. The kinetics of pullulan biosynthesis by black mutants indicated that the pullulan production was intensified beginning from the second day of culturing, as compared to strain A.p.-3.
On the basis of the literature the results of experimental investigations on hypocholesterolemic action of saponins are demonstrated. Also the theories explaining the mechanism of this action are discussed.
The current data on the occurrence, synthesis, liberation and specific receptors of cholecistokinine in tissues and body fluids have been presented. The potential of known competive antagonists of cholecistokinine in relation to the role it plays in animals and man was also discussed.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 20 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.