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1

A novel, stable, helical scaffold as an alternative binder - construction of phage display libraries

100%
Cyranka-Czaja A., Otlewski J.
Acta Biochimica Polonica
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2012
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tom 59
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nr 3
 Specific, high affinity binding macromolecules are of great importance for biomedical and biotechnological applications. The most popular classical antibody-based molecules have recently been challenged by alternative scaffolds with desirable biophysical properties. Phage display technology applied to such scaffolds allows generation of potent affinity reagents by in vitro selection. Here, we report identification and characterization of a novel helical polypeptide with advantageous biophysical properties as a template for construction of phage display libraries. A three-helix bundle structure, based on Measles virus phosphoprotein P shows a very favourable stability and solubility profile. We designed, constructed and characterized six different types of phage display libraries based on the proposed template. Their functional size of over 109 independent clones, balanced codon bias and decent display level are key parameters attesting to the quality and utility of the libraries. The new libraries are a promising tool for isolation of high affinity binders based on a small helical scaffold which could become a convenient alternative to antibodies.
2

Anti-bacterially pre-treated polyethylene by discharge plasma

100%
Novak I., Popelka A., Lehocky M., Sedliacik J., Matyasovsky J., Chodak I., Kleinova A.
Annals of Warsaw University of Life Sciences - SGGW. Forestry and Wood Technology
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2012
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tom 79
3

Biodegradable polymeric micelles based on thermosensitive poly[[methacrylamido]alkyl oligolactate] for delayed drug delivery

100%
Van Nostrum C. F., Soga O., Rijcken C. J. F., Ramzi A., Veldhuis T. F. J., Hennink W. E.
Cellular and Molecular Biology Letters
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2005
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tom 10
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nr Suppl.
4

Can silver nanoparticles affect the mineral content, structure and mechanical properties of chicken embryo bones?

80%
Sikorska J., Szmidt M., Sawosz E., Niemiec T., Grodzik M., Chwalibog A.
Journal of Animal and Feed Sciences
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2010
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tom 19
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nr 2
286-291
Biomedical application of silver nanoparticles has recently gained much attention. In this study, we investigated whether hydrocolloids of silver nanoparticles (nano-Ag) are deposited in chicken bones during embryogenesis and to what extent they can affect biochemical characteristics, mineral content, structure, and mechanical properties of bones. Hydrocolloids (0.3 ml), containing 50 ppm of nano-Ag, were injected in ovo prior to incubation of eggs. After 20 days of incubation, blood and thigh bones were isolated and analysed. Nano-Ag was deposited in embryo thigh bones, but did not affect the structure or mechanical properties of the bone. There was no effect of nano-Ag on the selected biochemical indices, but there was a tendency towards increasing mineral content, indicating that nanoparticles may influence bone mineralization. Considering that nano-Ag is absorbed by the embryo skeleton without affecting bone properties, these particles might be a good candidate for carriers of micronutrients or drugs into bones.
5
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Exploring the potential of Crotalaria juncea flower extracts as a source of antioxidants, antimicrobials, and cytoprotective agents for biomedical applications

80%
Mahasawat P., Boukaew S., Prasertsan P.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2023
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tom 104
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nr 4
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