Wyniki wyszukiwania - AGRO

1

Binding of histamine by gastric juice

100%

Zak-Nejmark T., Malolepszy J., Kuczynska-Sekieta K., Liebhart E., Liebhart J.

Archivum Immunologiae et Therapiae Experimentalis

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1989

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tom 37

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nr 1-2

2

Factors determining an efficacy of chitosan in the control of plant pathogens

100%

Pospieszny H., Struszczyk H.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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2003

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tom 51

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nr 3

3

Self-organizing neural network for modelling 3D QSAR of colchicinoids

100%

Polanski J.

Acta Biochimica Polonica

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2000

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tom 47

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nr 1

A novel scheme for modeling 3D QSAR has been developed. A method involving multiple self-organizing neural network adjusted to be analyzed by the PLS (partial least squares) analysis was used to model 3D QSAR of the selected colchicinoids. The model obtained allows the identification of some structural determinants of the biological activity of compounds.

4

Isothermal titration calorimetry studies of solubilizatin of DPPC vesicles by amphiphilic quaternary ammonium salts

100%

Pruchnik H., Rozycka-Roszak B.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.

5

Assessment of the biological activity and toxic properties of the herbal preparation Naran N

100%

Matysik G., Wojciak-Kosior M., Paduch R., Soczewinski E.

Herba Polonica

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2003

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tom 49

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nr 3-4

The toxicity and biological activity of aqueous extracts of herbal medicine Naran N were investigated using human skin fibroblast cells culture (HSF) of 2 x 104 and 1 x 10s cells/ml densities. The herbal drag Naran N is composed of four herbs: Flos Calendulae, Folium Plantaginis lanceolatae, Anthodium Chamomillae, Herba Euphrasiae; it was elaborated in the Department of Chemistry, Pharmaceutical Falcuty of Medical University of Lublin (Poland) and distributed on permission ofthe Polish Department of Hygiene (PZH) in 2001. Naran N is produced by Dyspak (Dys near Lublin, Poland) on licence of the Medical University of Lublin (PL-409218-B,). The investigations in the Institute of Microbiology and Biotechnology of UMCS of Lublin have shown that the aqueous extract of Naran N stimulates the proliferation of HSF cells of 1 x TO5 cells/ml density, the viability of cells remained on the control level. Similar viability was observed also for HSF culture of 2 x 10" cells/ml density. The results explain the healing activity of Naran N for chronic vascular diseases.

6

Biological activities of mixtures of organophosphorous herbicides

100%

Kleszczynska H., Bonarska D., Bielecki K., Sarapuk J.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

7

Determination of theoretical retention times for peptides analyzed by reversed-phase high-performance liquid chromatography

88%

Dziuba J., Minkiewicz P., Mogut D.

Acta Scientiarum Polonorum. Technologia Alimentaria

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2011

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tom 10

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nr 2

Background. Peptides are important components of foods mainly due to their biological activity. The basic method of their identification is reversed phase high-performance liquid chromatography coupled with electrospray-ionization mass spectrometry (RP-HPLC- -ESI-MS). Retention time (tR) prediction in silico is very helpful in analysis of multicomponent peptide mixtures. One of problems associated with RP-HPLC-ESI-MS is deterioration of mass spectra quality by trifluoroacetic acid (TFA). This problem can be avoided through the use of chromatographic columns designed for work with low TFA concentrations in mobile phase. The objective of this study was to determine the correlations between peptide retention times predicted with the use of a program available on-line and experimental retention times obtained using the column working with low TFA concentrations. Material and methods. The set of synthetic peptides and bovine α-lactalbumin fragments (18 peptides) was used in the experiment. Theoretical retention times were calculated using Sequence Specific Retention Calculator (SSRC) program. The experimental retention times were measured via RP-HPLC-ESI-MS method using column working with low TFA content. The dependence between theoretical and experimental tR was expressed via empirical equations. Results. The best correlation between theoretical and experimental retention times of peptides containing at least four amino acid residues has been obtained when third order polynomial (R2 = 0.9536). Prediction quality for diand tripeptides was significantly lower. The method described can be applied for cysteine-containing peptides although our sample preparation procedure did not include modification of this amino acid, taken into attention by SSRC program. Conclusions. The results of this study validate the usefulness of a third degree polynomial as a simple function describing the correlation between peptide retention times predicted by an on-line application and experimental retention times. The above function can effectively predict retention times in situations when experimental conditions differ from the computational environment (various columns, mobile phase composition, use or resignation from chemical modifications during sample preparation, various HPLC equipments). On-line available tR predicting application with correction based on user’s own data may be a useful tool in food peptidomics.

8

Gamma-lactones with potential biological activity

88%

Koziol A., Mroczko L., Niewiadomska M., Lochynski S.

Polish Journal of Natural Sciences

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2017

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tom 32

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nr 3

γ-Lactones are well known organic compounds. They can be isolated from many different plants, e.g. from Asteraceae (Compositae) family. They are used as active ingredients of various medicinal herbs and exhibit a variety of biological activities, i.e. antiviral, antibacterial, anticancer, antimalarial, anti-inflammatory and others. Among described compounds vernolide (7) is characterized by high antimicrobial activity; epoxy compounds like glaucolide (13) and hirsutinolide (24, 25, 26) possess high anticancer activity. Other noteworthy γ-lactone is vernopicrin (14) that shows antimalarial activity. Some of the γ-lactones possess interesting aromatic and flavon properties, which make them desirable ingredients in perfumery and food industry. Further studies to determine relationship between properties and complex composition are caused by diversity of structures and potential activities of γ-lactones. It can be used to design new analogues with interesting pharmacological, flavon and olfactory properties. This paper reviews selected studies concerning γ-lactones and their various biological activities.

9

Antibacterial properties of 4-N,N-dimethylaminoquinazoline derivatives

88%

Zielinski W., Kudelko A.

Pestycydy

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2006

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nr 1-2

29-36

10

Exchange of mercury between water and the wall of a vessel and its effect on the results of determinations

88%

Wrembel H. Z.

Oceanologia

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1981

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tom 13

11

Staphylococcal enterotoxins

88%

Bystron J., Molenda J.

Advances in Agricultural Sciences

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2004

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tom 09

12

Antibacterial activity of alkyltriphenylphosphonium salts

88%

Golebiewski W. M., Wilkowska E., Cieniecka-Roslonkiewicz A.

Pestycydy

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2002

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nr 1-4

13

Functional properties and biological activities of bovine casein proteins and peptides

88%

Darewicz M., Dziuba J., Dziuba M.

Polish Journal of Food and Nutrition Sciences

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2006

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tom 15/56

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nr Spec.Issue 1

This review is a brief description of the current state of research on the functional and bioactivite properties of caseins, their hydrolysates and peptides. The functional properties of casein and casein-originated hydrolysates and peptides reflect the natural features of their molecules and environmental characteristics. Many proteolytic enzymes are used for modifying functional and biological properties of caseins. Enzymatic modifications influence the conformation of casein molecules and, in consequence, their properties. The functional properties of caseins may improve upon partial hydrolysis. Peptides derived from casein proteins are capable of affecting the biological functions of an organism. These effects can be antihypertensive, antimicrobial, antithrombotic, immunoregulating and opioid.

14

The influence of alkylresorcinols on phospholipase A2 activity

88%

Czajkowska D., Mika J., Stasiuk M., Kozubek A.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.

15

Visual and archaeal rhodopsins: similarities, differences and controversy

88%

Bryl K.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 2

Rhodopsins are currently known to belong to two distinct protein families. The visual rhodopsins, found in eyes throughout the animal kingdom, are photosensory pigments. Archaeal rhodopsins, found in extreme halophiles, function as light-driven proton pumps (bacteriorhodopsins), chloride ion pumps (halorhodopsins), or photosensory receptors (sensory rhodopsins). Light absorption by rhodopsins triggers their characteristic photoconversion extending into the (milli)second time range. There are three main paradigms of rhodopsins photoconversion. (1) Initiation of the trans-cis isomerization is the very primary consequence of light absorption. (2) Rhodopsins store light energy via the charge-separation mechanism (the charge of Schiff base is separated from its counterion). (3) Full trans-cis isomerization of the chromophore is a prerequisite for the full biological activity of rhodopsins. These paradigms will be questioned.

16

The interaction of amphiphilic quaternary ammonium salts with model membranes: the counterion effect

88%

Rozycka-Roszak B., Zylka R.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

17

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Lichens as a source of chemical compounds with anti-inflammatory activity

75%

Studzinska-Sroka E., Dubino A.

Herba Polonica

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2018

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tom 64

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nr 1

Symptoms of inflammation accompany a number of diseases. In order to mitigate them, folk medicine has used a variety of medicinal substances, including herbs and mushrooms. Lichens are less known organisms, containing specific secondary metabolites with interesting biological properties. One of their biological actions is the anti-inflammatory activity that has been confirmed by in vitro and animal studies. It has been proven that compounds and extracts from lichens inhibit the enzymes involved in the inflammatory process. The following paper is a review of research on the little-known anti-inflammatory properties of lichens.

18

The role of cathelicidin LL-37 in cancer development

75%

Piktel E., Niemirowicz K., Wnorowska U., Watek M., Wollny T., Gluszek K., Gozdz S., Levental I., Bucki R.

Archivum Immunologiae et Therapiae Experimentalis

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2016

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tom 64

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nr 1

19

The macromolecular aggregate as a drug carrier

75%

Langer M., Ugorski M.

Cellular and Molecular Biology Letters

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2000

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tom 05

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nr 4

433-440

Traditionally, a drug is expected to be biologically active and at the same time be able to ensure some sort of tissue or organ specificity. The latter property is necessary to avoid undesirable side effects when toxic drugs are being used. Such requirements are difficult to achieve only by changing the chemical formula of the drug. For these reasons, within the last few years a new pharmacological concept has been developed regarding delivery of biologically active compounds by the use of macromolecular aggregates. The purpose-specific design of macromolecular aggregates, able to deliver drugs to a desired location, is based on the assumption that different functions can be assigned to the separate chemical entities forming the aggregate. With the help of such an aggregate, the biologically active compound can be designed with solely its pharmacological potency in mind and without considering any limitations imposed by inaccurate delivery, such as undesired side effects. Specific molecules of the aggregate would ensure desired compound distribution within the organism. Furthermore, other molecules forming the aggregate should fulfill additional functions, e.g. protecting the drug from degradation. Additionally, aggregates formed from amphiphilic molecules should be capable of carrying drugs that are difficult to use as therapeutic agents due to low solubility in biological fluids (e.g. Taxol) or degradation (e.g. peptides, DNA). Such aggregates can be constructed from natural or/and synthetic compounds. Taken together, this creates possibilities of extending the spectrum of drug application and allows for the introduction of new technological modifications.

20

Formulation of multipesticide emulsifiable concentrates

75%

Turos-Biernacka M., Walcerz L.

Pestycydy

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1990

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nr 2-3

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