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Estradiol and progesterone release from biodegradable copolymer: effect on activity of microsomal mixed function oxidase system in rat liver

100%

Plewka A., Kaminski M., Glogowska-Szelag J., Nowak M., Buntner B., Gorski J., Kajdaniuk D.

Polish Journal of Environmental Studies

1996

tom 05

nr 4

The cytochrome P-450 dependent monooxygenase system is responsible for metabolism of exo- and endogenous compounds. It is induced or inhibited by many factors, including hormones. The effects of hormones on this system depend on the dose, manner and route of administration. The aim of this study was to test a controlled long-acting system of estradiol-progesterone release from a biodegradable copolymer and to evaluate the influence of the copolymer alone, or the copolymer with estradiol or progesterone on the hepatic enzymatic system responsible for biotransformation of xenobiotics. We have shown that the copolymer slightly affects the activity of the cytrochrome P-450 - dependent mixed oxygenase system (MFO), but not the desaturase system. Estradiol and progesterone modified the MFO activity in a typical manner.

In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers

84%

Kryczka T., Bero M., Kasperczyk J., Dobrzynski P., Marciniec B., Popielarz-Brzezinska M., Grieb P.

Acta Biochimica Polonica

2002

tom 49

nr 1

The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37°C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics of nucleoside release from the copolymers were measured over 50 days. Four copolymers exhibited relatively constant release of nucleosides in micromolar concentrations during the entire observation period. Sterilization with either ethylene oxide or gamma radiation only slightly influenced nucleoside release. Further development of these copolymers as an intracerebral nucleoside delivery system for local treatment of brain tumors is indicated.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Polish Journal of Environmental Studies

1 Bero M.

1 Buntner B.

1 Dobrzynski P.

1 Glogowska-Szelag J.

1 Gorski J.

1 Grieb P.

1 Kajdaniuk D.

1 Kaminski M.

1 Kasperczyk J.

1 Kryczka T.

1 Marciniec B.

1 Nowak M.

1 Plewka A.

1 Popielarz-Brzezinska M.

1 2002

1 1996

Wyniki wyszukiwania

Estradiol and progesterone release from biodegradable copolymer: effect on activity of microsomal mixed function oxidase system in rat liver

In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers