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Arginase isoenzymes in human cirrhotic liver

100%

Chrzanowska A., Gajewska B., Baranczyk-Kuzma A.

Acta Biochimica Polonica

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2009

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tom 56

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nr 3

465-469

Cirrhosis leads to an inability of the liver to perform its biochemical functions. It can also lead to hepatocellular carcinoma in which, as we showed lately, arginase isoenzyme pattern changes. The present work presents our results on arginase isoenzymes and their possible role in liver cirrhosis. The study was performed on tissues obtained during liver transplantation from 60 patients with liver cirrhosis, and on samples of histologically normal liver (control) from 40 patients with benign or colorectal cancer liver metastases removed during surgery, 6-7 cm from the tumor border. Arginase isoenzymes AI (so-called liver-type arginase) and AII (called extrahepatic arginase) were identified by Western blotting and isolated by ion-exchange chromatography. Their expression on mRNA level was studied by RT-PCR. A significant decrease in arginase activity, dependent of the liver clinical stage, was observed in cirrhotic tissue. Arginase AI activity and its mRNA level were significantly decreased in cirrhotic liver, whereas the activity and expression of arginase AII were concurrently raised, as compared to normal liver. Since arginase AI is a key enzyme of the urea cycle, whereas arginase AII most probably takes part in the biosynthesis of ornithine and polyamines, the defective ammonia inactivation and increased collagen biosynthesis observed in cirrhotic liver may be related to the changes in arginase AI and AII levels, respectively.

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Using X-ray fluoresces analysis to assess level of major and trace elements in cultivated vegetables at Baghdad city

100%

Mutter M. M.

International Letters of Natural Sciences

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2016

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tom 52

The aim of this study was determine the current levels of major and a trace element in vegetables was grown in Baghdad city, two region check in this study (Al-Taji, north of Baghdad and Al-Rashid south of Baghdad).Qualitative X-ray fluorescence analysis was used as technique for analysis of samples. Six different samples of plant are selected to study, which was tubers, leafy and fruiting .Samples checking was Lettuce, Bean, Apples, Potato, Cabbage and pear. Elements analysis as major elements were (Ca, K and Mn) and trace elements were (Fe, Cu, Pb, Sr and Zn). Results showed that concentrations of elements are in relative agree with the concentrations in neighbor countries and the standards of IAEU.

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Arsen i nikiel w srodowisku i w organizmie zwierzat

75%

Zasadowski A., Spodniewska A.

Acta Academiae Agriculturae ac Technicae Olstenensis. Veterinaria

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1995

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tom 22

121-133

W pracy przedstawiono najważniejsze aspekty związane z występowaniem arsenu i niklu w środowisku naturalnym i organizmie zwierząt. Uwzględniono przede wszystkim okoliczności skażeń środowiska, podstawowe funkcje biochemiczne i mechanizm działania, znaczenie w środowisku naturalnym i organizmie zwierząt, a także podstawowe efekty toksykologiczne związane z intoksykacją tymi pierwiastkami.

Ograniczanie wyników

1 Acta Academiae Agriculturae ac Technicae Olstenensis. Veterinaria

1 Acta Biochimica Polonica

1 International Letters of Natural Sciences

1 Baranczyk-Kuzma A.

1 Chrzanowska A.

1 Gajewska B.

1 Mutter M. M.

1 Spodniewska A.

1 Zasadowski A.

1 2016

1 2009

1 1995

Arginase isoenzymes in human cirrhotic liver

Using X-ray fluoresces analysis to assess level of major and trace elements in cultivated vegetables at Baghdad city

Arsen i nikiel w srodowisku i w organizmie zwierzat