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The chicken alpha- and beta-globin gene domains and their chromatin organization

100%

Recillas-Targa F.

Cellular and Molecular Biology Letters

2000

tom 05

nr 4

451-467

The eukaryotic genome is organized into discrete chromatin domains. The globin groups of genes have been two of the classical biological systems to study the relationship between gene regulation and chromatin structure during development. The individual promoters, enhancers and silencers of the globin genes are stage- and tissue-specific regulatory elements that are controlled by the interaction of ubiquitous and erythroid nuclear factors. Such regulated activation requires an optimal chromatin organization. Erythroid and constitutive DNase I hypersensitive sites (DHs) contribute to chromatin domain remodeling mediated by locus control region (LCR) activity and defined by domain boundaries. A comparative analysis of the chicken α-and β-globin domains will outline the relevance and effect of chromatin structure on gene regulation.

Modification of pre-mRNA splicing by antisense oligonucleotides

100%

Kole R.

Acta Biochimica Polonica

1997

tom 44

nr 2

Antisene oligonucleotides have been extensively studied as agents that inhibit the expression of undesirable genes in a sequence specific manner. Results reviewed in this article show that antisene oligonucleotides can also restore the expression of genes inactivated by mutations causing genetic diseases. In this novel application, antisene oligonucleotides block aberrant splice sites created by the mutations, forcing the spliceosomes to form at correct splice sites, thus restoring the proper splicing pathway and consequently the activity of the damaged gene.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Cellular and Molecular Biology Letters

1 Kole R.

1 Recillas-Targa F.

1 2000

1 1997

Wyniki wyszukiwania

The chicken alpha- and beta-globin gene domains and their chromatin organization

Modification of pre-mRNA splicing by antisense oligonucleotides