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A comprehensive review on bergenin, a potential hepatoprotective and antioxidative phytoconstituent

100%

Rastogi S., Rawat A. K. S.

Herba Polonica

2008

tom 54

nr 2

Bergenin (1) is a C-glucoside of 4-O-methylgallic acid that has been reported to occur naturally in several genera. It exhibits a wide array of biological activities and also in several cases is responsible for the traditional use of its natural sources. It has been shown to exhibit various pharmacological activities, and thus has several possible applications in clinical research. This review presents a comprehensive literature search of different studies carried out on this secondary metabolite, especially its hepatoprotective potential, antioxidative and antiviral effects as well as antiulcerogenic and antiarthritic activities. Bergenin seems to be a potent phytotherapeutic agent as demonstrated by experimental data in animal models. Therefore, further investigations may help in exploiting its properties and developing phyto-pharmaceuticals based on it.

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Effect of bergenin on the kidney of C57BL/6J mice with high fat-diet induced oxidative stress

84%

Sagadevan A., Ramalingam S.

International Letters of Natural Sciences

2016

tom 54

The present study evaluated the protective effect of bergenin on high fat diet (HFD) induced diabetic mice. C57BL/6J mice were segregated in two groups, one fed standard diet (NC) and the other fed HFD for 16 weeks. Mice were fed continuously with high fat diet for 16 weeks and subjected to intragastric administration of bergenin (10, 20 and 40 mg/kg body weight (BW)), metformin (25 mg/kg BW) 9 to 16 weeks. At the end of the treatment nephritic markers, lipid peroxidation product, antioxidant and histopathological examination were carried out to assess the efficacy of the treatment. HFD fed mice showed increased plasma glucose, insulin, altered nephritic markers, antioxidant and histopathological abnormalities. Oral Treatment with bergenin (40 mg/kg BW) showed near normalized levels of plasma glucose, lipid peroxidation product, antioxidants, improved insulin and reduced kidney damage. The effects of bergenin were comparable with standard drug, metformin. These data suggest that bergenin protect kidney from deleterious effect of glucose.

Ograniczanie wyników

1 Herba Polonica

1 International Letters of Natural Sciences

1 Ramalingam S.

1 Rastogi S.

1 Rawat A. K. S.

1 Sagadevan A.

1 2016

1 2008

Wyniki wyszukiwania

A comprehensive review on bergenin, a potential hepatoprotective and antioxidative phytoconstituent

Effect of bergenin on the kidney of C57BL/6J mice with high fat-diet induced oxidative stress