Propolis is produced by bees; it is a viscous, resinous substance mainly derived from trees, shrubs, and flower buds, enriched in wax, essential oils, pollen, and bee saliva. The composition of propolis varies widely depending on the region of origin and vegetation that occurs in the area, the climate, and the season in which it is produced. So far, more than 400 substances have been identified in propolis and among them are phenols, flavonoids, phenolic acids and their esters and flavones. Propolis is divided into several types; the most common types are poplar, European, Brazilian, and pacific propolis. Antimicrobial, antifungal, and antiviral effects of propolis have been demonstrated. Propolis inhibits Gram-positive bacteria and, to a lesser extent, Gram-negative bacteria. Propolis also inhibits the growth of mold (Aspergillus and Penicillium) and yeast (Candida). The antiviral activity of propolis against poliovirus, influenza A and B viruses, reoviruses, and HIV has been demonstrated.