A mixture containing Xylazine (30 mg), Ketamine (150 mg), fentanyl (0.1 mg), and guaifenasin (5000 mg) in 100 ml of 5% glucose solution was infused intra venously in 7 healthy adult dogs. Anesthesia was induced with an initial dose (0.55 ml/kg) of the mixture administered rapidly as a bolus and then maintained by a constant infusion at a rate of 2 ml/kg/h. The induction was without excitation, the state of surgical tolerance was stable at the level 3/III, and after an average of 40 min afer the end of the infusion the dogs were able to stand up. There was noted bradycardia in the first period of anesthesia. This was connected with a decrease of cardiac output. At the same time the frequency of breaths and the minute ventilation volume decreased causing a temporary respiratory acidosis. The dose of both Xylazine and Ketamine needed for performance of anesthesia was 5 times lower than the doses of these agents used separately in a traditional way. This composition, in the suggested concentrations and used as a drip facilitated control of the level and time of anesthesia, is an alternative to the simple and safe procedure of infusion anesthesia.
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