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Cytoplasmatic bacterial membrane responses to environmental perturbations

100%

Mrozik A., Piotrowska-Seget Z., Labuzek S.

Polish Journal of Environmental Studies

2004

tom 13

nr 5

Bacteria can adapt to various environmental factors such as temperature, pressure, ions, nutrients and toxic substances by modifying their membranes to maintain them in a fluid state. These modifications within the cytoplasmatic membrane particularly result from changes in the fatty acid composition and interaction between proteins and lipids. Fatty acids, mainly phospholipid fatty acids, play a role as a good biomarker of changes of physiological status of microorganisms caused by external factors. A greater understanding of the detailed physiological mechanisms of bacterial membrane lipid adaptation, especially to toxic substances and solvents, are important for researchers who use bacteria in bioremediation and biotransformation processes.

Construction and optimisation of a computer model for a bacterial membrane

72%

Murzyn K., Pasenkiewicz-Gierula M.

Acta Biochimica Polonica

1999

tom 46

nr 3

The main steps in the construction of a computer model for a bacterial membrane are described. The membrane has been built of 72 lipid molecules, 54 of which being 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphatidylethanolamine (POPE) and 18 - 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphatidyl-rac-glycerol (POPG) molecules (thus in the proportion of 3:1). The membrane was hydrated with 1955 water molecules (approximately 27 water molecules per lipid). To neutralise the electronic charge (-e) on each POPG molecule, 18 sodium ions (Na+) were added to the membrane close to the POPG phosphate groups. The atomic charges on the POPE and POPG headgroups were obtained from ab initio quantum mechanical restrained electrostatic potential fitting (RESP) (Bayly et al., 1993, J. Phys. Chem. 97, 10269) using the GAMESS program at the 6-31G* level (Schmidt et al., 1993, J. Comput. Chem. 14, 1347). The model constructed in this way provided an initial structure for subsequent molecular dynamics simulation studies intended to elucidate the atomic level interactions responsible for the structure and dynamics of the bacterial membrane.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Polish Journal of Environmental Studies

1 Labuzek S.

1 Mrozik A.

1 Murzyn K.

1 Pasenkiewicz-Gierula M.

1 Piotrowska-Seget Z.

1 2004

1 1999

Wyniki wyszukiwania

Cytoplasmatic bacterial membrane responses to environmental perturbations

Construction and optimisation of a computer model for a bacterial membrane