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Background: Frontal sinuses are 2 irregular cavities, placed between 2 lamina of frontal bone. Expansion continues during childhood and reaches full size after puberty. Persistent metopic suture is one of the factors that are related to abnormal frontal sinus development. In this study, we want to discuss about the coexistence of persistent metopic suture and abnormal frontal sinus development using radiological techniques. Materials and methods: In this retrospectively planned study, images of 631 patients were examined, 217 (34.4%) of them were men and 414 (65.6%) of them were women. Brain computed tomography and magnetic resonance images were retrieved from the electronic archive for analysis. Results: In this study, frontal sinus development is categorised as right side atrophy, left side atrophy, bilateral atrophy and bilaterally developed sinuses. The presence of metopic suture was accepted as persistent metopic suture. Frontal sinus atrophy was found in 22.7% and persistent metopic sutures were found in 9.7% of overall. Conclusions: In this study, no significant results were detected that were related to the frontal sinus agenesis or dismorphism associated with persistent metopic suture. We conclude that, although publications propounding metopism that leads to abnormal frontal sinus development are present in the literature, no reasonable explanation has been mentioned in these articles; and we believe that these findings are all incidental. (Folia Morphol 2013; 72, 4: 306–310)
Spinobulbar muscular atrophy (SBMA) is an X-linked form of motor neuron disease characterized by progressive atrophy of the muscles, dysphagia, dysarthria and mild androgen insensitivity. SBMA is caused by CAG repeat expansion in the androgen receptor gene. CAG repeat polymorphism was analysed in a Polish control group (n = 150) and patients suspected of SBMA (n = 60). Normal and abnormal ranges of CAG repeats were established in the control group and in 21 patients whose clinical diagnosis of SBMA was molecularly confirmed. The ranges are similar to those reported for other populations.
This paper describes clinical and pathomorphological features of myasthenia gravis in a 7-year-old male German Shepherd dog. At clinical examination, many neurological deficits as well as swallowing and urinating problems were detected. Radiological examination revealed megaoesophagus and the ELISA test showed an elevated serum acetylcholine receptor (AChR) antibody titer. No improvement was observed after the administration of edrophonium hydrochloride. The diagnosis of myasthenia gravis was confirmed by electromyography. Despite the administration of pyridostygmine bromide, dexamethasone and antibiotics, no improvement followed, and the dog died. Necropsy was conducted: histopathological changes in the esophagus, cranial tibial muscle and lungs were described as muscular atrophy, muscular fibrosis and aspiration pneumonia. The dog’s littermate was examined and showed an elevated AChR antibody titer too, but was asymptomatic.
The present study deals with the influence of experimental ZEA mycotoxicosis on histopathological lesions in ovaries of bitches, which were administered zearalenoneperos during anestrus phase for one hundred days. The experiment was performed on 9 sexually mature, clinically healthy bitches. The animals assigned into two experimental groups received zearalenone per os at two doses, 25 μg/kg b.w. and 50 μg/kg b.w., respectively: the bitches from control group received placebo per os. On the last day of zearalenone intoxication, the bitches were ovariohystorectomized. Histopathology and immunohistochemistry were performed. The study revealed that zearalenone and its metabolites caused profound regressive lesions: granular cells degeneration and atrophy. Numerous edemas and blood extravasations were also found. The intensity of these changes was significantly dose dependent. Furthermore, in ovarian cells and tissues of both experimental groups, no reaction for PCNA antigen was observed. In conclusion, zearalenone and its metabolites exerts unfavorable effects on the morphology of ovaries in bitches.
The studies were carried out in the Włoszczowa Forest Unit, in 9 ash stands differing in respect of age, origin (natural, artificial), site and in the nursery on 3 quarters differing due to a silvicultural method (transplanted and not transplanted) and seedlings age. In each stand an analysis of disease symptoms was carried out on 100 trees (2 - 20 years old stands) or 50 trees (21 - 80 years old stands) growing side by side in central part of the stand, while in the nursery in each block 200 seedlings were analyzed (4 sectors with 50 seedlings each). From the infected seedlings and trees 120 fragments of dead branches, living branches with cankers, and dead roots were taken. Identification of fungi was made on the basis of fructification and over 300 isolations of fungi on malt agar medium. The most frequent disease symptoms in ash stands were: the dead top (34.7% trees), the dying of whole branches (83.5%), the dying of the top of branches (20.1%), the occurrence of healed (36.0%) and unhealed cankers (18.9%) and the slime flux (23.7%) on the trunk, also the chlorosis of leaves (7.5%) and their atrophy (11.2%). Most of the types of disease symptoms appeared irrespectively of the tree age, origin and site, sometimes showing only a difference in the frequency of occurrence. On the seedlings in the nursery the shoot discolouration, healed and unhealed cankers on shoots and necrosis of a part of leaves were recorded most frequently. Disease symptoms occurred more frequently on 4-year-old seedlings in comparison with 3-year-old. In respect of transplanted seedlings the leaves dying was more frequent. Within cankers and on dead tops of shoots the most frequent were: Alternaria alternata, Chalara sp., Cytospora ambiens, Diplodia mutila, Fusarium lateritium, Gloeosporidiella turgida, Phomopsis controversa and Phomopsis scobina. In sparsely found dead roots of living trees appeared mostly: Cryptosporiopsis radicicola, Cylindrocarpon destructans and Phialocephala sp.
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