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1

The impact of left main coronary artery morphology on the distribution of atherosclerotic lesions in its branches

100%
Ajayi N. O., Lazarus L., Vanker E. A., Satyapal K. S.
Folia Morphologica
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2013
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tom 72
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nr 3
Background: Atherosclerotic occlusion of a coronary vessel is the commonest cause of ischaemic heart disease. The distribution of atherosclerotic lesions is not random, with stenoses preferentially situated at branch ostia, bifurcation points, and the proximal segments of daughter vessels. The aim of this study was to determine the effect of the intrinsic anatomical properties of the left main coronary artery (LMCA) on the distribution of atherosclerotic lesions in its branches. Materials and methods: A retrospective review of 170 consecutive coronary angiograms obtained from the cardiac catheterisation laboratories of private hospitals in the eThekwini Municipality area of KwaZulu-Natal, South Africa was performed. The LMCA was absent in 19/170 (11.2%). The remaining angiograms (n = 151) were divided into two groups: normal 63/151 (41.7%) and those with coronary artery disease (CAD) 88/151 (58.3%). The CAD group was sub-divided into proximal 42/88 (47.7%), mixed (proximal and distal) 26/88 (29.6%) and distal 20/88 (22.7%) sub-groups based on the location of atherosclerotic lesions in the branches of the LMCA. Results and Conclusions: The mean length, diameter and angle of division of the LMCA were as follows: Total angiograms: 10.4 mm, 3.8 mm and 86.2°; normal group: 10.5 mm, 3.9 mm and 85.7°, CAD group: 10.2 mm, 3.7 mm and 86.3°; proximal sub-group: 10.9 mm, 3.7 mm and 91.6°, mixed sub-group — 9.8 mm, 3.7 mm and 85° and distal sub-group — 9.1 mm, 3.8 mm and 79.4°, respectively. The vessels with proximally located lesions were recorded to have longer lengths and wider angles of division than vessels with distal lesions. Coronary angiographic delineation of the LMCA anatomy may be predictive of a coronary arterial arrangement that may favour the progression of proximally located lesions. (Folia Morphol 2013; 72, 3: 197–201)
2

Haemoglobin scavenger receptor: function in relation to disease

100%
Zuwala-Jagiello J.
Acta Biochimica Polonica
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2006
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tom 53
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nr 2
Highly efficient systems remove the toxic and proinflammatory haemoglobin from the circulation and local sites of tissue damage. Macrophages are major haemoglobin-clearing cells; CD163 was recently recognized as the specific haemoglobin scavenger receptor (HbSR). It is tightly involved in both physiological as well as pathophysiological processes, such as cytoprotection and inflammation. Haemoglobin functions as a double-edged sword. In moderate quantities and bound to haptoglobin, it forms a ligand for haemoglobin scavenger receptor CD163/HbSR, but when unleashed in large amounts, it can become toxic by mediating oxidative stress and inflammation. CD163/HbSR plays a crucial role in the control of inflammatory processes, probably in part through its effects on both ferritin induction and subsequent induction of antiinflammatory pathways through interleukin-10 and haem oxygenase. Besides the observation that the haemoglobin scavenger receptor provides a promising target for new treatment possibilities, it offers a novel view on the aetiology of diverse physiological as well as pathophysiological processes. In addition, monocyte CD163/HbSR and soluble CD163/HbSR are potential diagnostic tools in a variety of disease states, such as inflammation, atherosclerosis, transplant rejection, and carcinoma.
3

Circulating monocyte chemoattractant protein-1 in women with gestational diabetes

67%
Telejko B., Kuzmicki M., Zonenberg A., Niedziolko-Bagniuk K., Nikolajuk A., Szamatowicz J., Gorska M.
Folia Histochemica et Cytobiologica. Supplement
|
2007
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tom 45
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nr 1
153-156
4

Czynniki ryzyka stresu oksydacyjnego oraz rozwoju zmian miazdzycowych w grupie otylych kobiet po menopauzie

59%
Grygiel-Gorniak B., Przyslawski J., Gorna I., Chuchracki M.
Bromatologia i Chemia Toksykologiczna
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2009
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tom 42
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nr 3
937-940
5

The effect of diet supplementation with beta-carotene, vitamin C and E on peroxidation processes and atherosclerosis development in the model of experimental hypercholesterolaemia

59%
Ziemlanski S., Panczenko-Kresowska B.
Żywienie Człowieka i Metabolizm
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1995
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tom 22
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nr 1
The purpose of the study was the assessment of the intensity of peroxidation processes during experimental hypercholesterolaemia and the comparison of the antioxidative action of beta-carotene with that of vitamins C and E. The experiment was cairied out on 50 guinea pigs receiving a diet containing 0.2% of cholesteroli A part of the animals received additionally beta-carotene (50 mg per 100 g of lhe diet), another part was given vitamin E (10 mg/ 100 g of the diet), vitamin C (500 mg/100 g of the diet) and beta-carotene (50 mg/ 100 g of the diet). Histological examinations of the thoracic and abdominal aorta demonstrated in hypercholesterolemia animals a significant reduction of lipid infiltrations in the group receiving supplements of these vitamins. Beta-carotene was found to inhibit the development of atherosclerotic lesion in the same degree as all three antioxidative vitajnins ailmitiislered jointly. In biochemical investigations it was shown that the administration of beta-carotene or the complex of antioxidative vitamins inhibited in the same degree the rise of TBA-IiS produced by high-cliolesterol diet. The study confirmed also a positive correlation between TBA-RS concentration an the activity of CK and CK-MB enzymes. The presence of vitamin C and E in the atherogenic diet exerted a more beneficial effect than beta-carotene on the distribution of cholesterol in HDL and LDL fractions.
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