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1

Homocysteine in atherogenesis

100%
Szostak W. B., Olszewski A. J.
Żywienie Człowieka i Metabolizm
|
1990
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tom 17
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nr 4
Omówiono rolę homocysteiny w powstawaniu miażdżycy. Inni autorzy opisali zaawansowaną miażdżycę u pacjentów z homocystynurią. Wykazano także, że eksperymentalną miażdżycę można wywołać poprzez karmienie zwierząt homocysteiną i jej pochodnymi. Pirydoksyna jest istotnym składnikiem odżywczym odpowiedzialnym za przemianę homocysteiny do kwasu taurocholowego. Wykazano, że zbyt niskie spożycie pirydoksyny powoduje homocystynurię u ludzi i miażdżycę u zwierząt. Autorzy wykazali zwiększone stężenie homocysteiny w surowicy osób, które przebyły zawał mięśnia sercowego. Hipercholesterolemii towarzyszy szczególnie wysoki poziom homocysteiny we frakcji LDL. In vitro LDL modyfikowane tiolaktonem homocysteiny wykazują szczególne powinowactwo do makrofagów mysich. Pirydoksyna podana razem z niektórymi innymi witaminami powoduje u osób po zawale mięśnia sercowego znaczny spadek poziomu homocysteiny w surowicy. Autorzy wnioskują, że genetycznie uwarunkowane łagodne zaburzenia w metabolizmie homocysteiny mogą w pewnej części populacji przyczyniać się do rozwoju przedwczesnej miażdżycy w przypadku, kiedy dieta jest bogata w metioninę i niedoborowa w pirydoksynę.
2
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Content available

Isoprostanes in atherosclerosis

100%
Oguogho A., Sinzinger H.
Journal of Physiology and Pharmacology
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2000
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tom 51
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nr 4,1
3

A study of the interaction of the C-reactive protein monomer with the U937 monocyte

84%
Zhao J., Shi X.-H.
Cellular and Molecular Biology Letters
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2010
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tom 15
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nr 3
485-495
C-reactive protein (CRP) has two structurally distinct isoforms, the CRP pentamer and the CRP monomer. A role for the CRP monomer in atherosclerosis is emerging, but the underlying mechanisms are only beginning to be understood. Monocytes are an important contributor to atherosclerosis, and foam cell formation is the hallmark of atherogenesis. However, whether the CRP monomer can directly interact with the monocytes and modulate their responses remains unknown. Furthermore, although FcγRIII (CD16) has been identified as the receptor for the CRP monomer on neutrophils, its role in mediating the CRP monomer’s biological effects in other cell types has been questioned. In this study, we investigated the interaction of the CRP monomer with the monocytes using the U937 monocytic cell line. The CRP monomer specifically binds to U937 cells. This binding is unique in that it is independent of FcγRs and insensitive to protease digestion of the cell surface proteins. Further assays revealed that the CRP monomer directly incorporates into the plasma membrane. Interestingly, the presence of the CRP monomer efficiently retards oxidized low-density lipoprotein-induced foam cell formation of PMA-differentiated U937 macrophages and peripheral blood monocytic cell-derived macrophages. These findings provide additional evidence for the notion that the CRP monomer is an active CRP isoform that plays a role in atherogenesis via the direct modulation of the behavior of the monocytes.
4
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The effect of nebivolol on atherogenesis in apoE - knockout mice

84%
Kus K., Gajda M., Pyka-Fosciak G., Toton-Zuranska J., Pawlowska M., Suski M., Niepsuj A., Nowak B., Wolkow P., Olszanecki R., Jawien J., Korbut R.
Journal of Physiology and Pharmacology
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2009
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tom 60
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nr 4
163-165
Nebivolol is a novel beta1-blocker with a nitric oxide (NO) - potentiating, vasodilatory effect that is unique among beta-blockers. It was already shown that nebivolol ameliorates atherosclerosis in cholesterol-fed rabbits. We, therefore, wanted to investigate whether this is the case in the fine experimental model of atherosclerosis: apolipoprotein E (apoE)- knockout mice. Nebivolol attenuated atherogenesis, measured both by "en face" method (9.23±1.8% vs. 14.6±2.1%) and "cross-section" method (63125±8455 µm2 vs. 91416±8357 m2). This is the first report showing the effect of nebivolol on atherogenesis in gene-targeted mice.
5
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Propionate reduces the cytokine-induced VCAM-1 and ICAM-1 expression by inhibiting nuclear factor-kappaB (NF-kappaB) activation

84%
Zapolska-Downar D., Naruszewicz M.
Journal of Physiology and Pharmacology
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2009
|
tom 60
|
nr 2
123-131
Adhesion and migration of leukocytes into the surrounding tissue are crucial steps in inflammation, immunity and atherogenesis. Expression of cell adhesion molecules by endothelial cells plays a role in these processes. Propionate is a naturally occurring short chain fatty acid produced by bacterial fermentation of dietary fibre. High intake of dietary fibre has been associated with an improved bowel function and with a reduced risk of cardiovascular disease. However, the molecular mechanisms responsible for these effects remain unknown. In this study, the effects of propionate on the expression of endothelial leukocyte adhesion molecules by cytokine-stimulated human umbilical vein endothelial cells (HUVEC) were investigated. Pretreatment of HUVEC with propionate significantly inhibited the tumor necrosis factor-alpha (TNF-)-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) in a time- and dose-dependent manner. At 10 mM, propionate also inhibited the interleukin-1 (IL-1)-mediated VCAM-1 and ICAM-1 expression, with the latter effect being more pronounced, as well as decreased the TNF--induced VCAM-1 and ICAM-1 mRNA expression in a similar manner. The decrease in VCAM-1 and ICAM-1 expression was associated with a reduction of adherence of monocytes and lymphocytes to the cytokine-stimulated HUVEC. In addition, propionate significantly inhibited the TNF--induced activation of nuclear factor-kappa B (NF-B) and significantly increased the expression of peroxisome proliferator-activated receptor alpha (PPAR) in HUVEC. These results demonstrate that propionate may have antiinflammatory and possibly antiatherogenic properties. Our findings warrant further investigation into the therapeutic effects of propionate on a number of pathological events involving leukocyte recruitment.
6
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AVE 0991 - angiotensin-(1-7) receptor agonist, inhibits atherogenesis in apoE - knockout mice

84%
Toton-Zuranska J., Gajda M., Pyka-Fosciak G., Kus K., Pawlowska M., Niepsuj A., Wolkow P., Olszanecki R., Jawien J., Korbut R.
Journal of Physiology and Pharmacology
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2010
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tom 61
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nr 2
Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes. It was also proved that Ang II promotes atherogenesis. Angiotensin-(1-7) [Ang-(1-7)] opposites Ang II action. Therefore, we would like to find out whether Ang-(1-7) receptor agonist: AVE 0991, could ameliorate atherosclerosis progression in an experimental model of atherosclerosis: apolipoprotein E (apoE) - knockout mice. AVE 0991 inhibited atherogenesis, measured both by “en face” method (7.63±1.6% vs. 14.6±2.1%) and “cross-section” method (47 235±7 546 µm2 vs. 91 416±8 357 µm2). This is the first report showing the effect of AVE 0991 on atherogenesis in gene-targeted mice.
7
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Evaluation of fatty acids daily intake and diets atherogenicity of dietetics students of Wroclaw Medical University

84%
Regulska-Ilow B., Ilow R., Kawicka A., Rozanska D., Salomon A., Dudziak K., Konikowska K.
Roczniki Państwowego Zakładu Higieny
|
2013
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tom 64
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nr 3
Background. Dietary and lifestyle risk factors play an important role in the pathogenesis of cardiovascular disease (CVD). The excessive intake of products that could affect atherogenic effect and are rich sources of saturated fatty acids (SFA) and cholesterol conductive the occurrence of lipid metabolism disturbances in the body. Objective. Evaluation of fatty acids dietary intake and assessment of the students’ diets atherogenicity in the aspect of the CVD risk. Material and methods. The study was conducted in 2011-2012. The study group included 100 females, dietetic students of the Wroclaw Medical University. The average age of the students was 21 years. Dietary habits were evaluated by the 3-day diet record method including one weekend day. Results. Average energy intake was 1673.9 kcal per day. The average daily total fat intake was 65.4 g and provided 34.5% of total energy intake. The percentage of energy from SFA in the diets of 82% students exceeded the recommended 10% and averaged 13.1%. The average percentage of energy from monounsaturated fatty acids (MUFA) in the students diets was 12.9% and in the diets of 5% students did not exceeded recommended 10%. The average percentage of energy from polyunsaturated fatty acids (PUFA) was 5.7% and in the diets of 66% students did not fulfilled the recommended 6-10%. About 80% of the students consumed less than recommended 2 g of C18:3 per day. Insufficient intake of EPA and DHA was observed in 71% students’ diets. The average n-6/n-3 PUFA ratio was 7.2 and in the 76% of female diets exceeded the recommended value of 4:1. The diets of 80% of students were considered as atherogenic, because of elevated value of Keys score. The ratio between PUFA and SFA in the female diets was incorrect and amounted to 0.52 (recommended value >1.0). Conclusions. Incorrect energy intake from daily diet and improper dietary intake of selected fatty acids in the diets of students may contribute to the development of CVD.
8

Dietary gender differences in terms of the risk of atherogenesis in Poland

84%
Smidowicz A., Regula J.
Acta Scientiarum Polonorum. Technologia Alimentaria
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2015
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tom 14
|
nr 3
Introduction. Diet plays an important role in prevention of atherosclerosis. The objective of the study was to assess differences in the dietary intake and nutritional status in women and men in terms of atherogenesis risk. Material and methods. The study involved 41 women and 49 men aged 40+. The nutrient intake was assessed using 7-day dietary records. The nutritional status was estimated on the basis of antropometric measurements and biochemical blood parameters. The differences between diets and the nutritional status depending on sex was evaluated by oneway analysis of variance. The dependencies between the nutritional status and the diet factors were assessed using multiple regression. Results and discussion. It was found that a significant proportion of the women and men were overweight or obese, had lipid disorders and impaired fasting glucose. Diets of women and men were poorly balanced. A significant correlation between the level of energy from protein, as well as the energy supply and the LDL cholesterol concetration was found in the women. A positive correlation between energy from protein as well as total energy in the diet and body weight, was observed in women and men. Moreover, protein intake was positively correlated with BMI and waist circumference among the men. In the men, the level of serum triglycerides correlated with an increase in dietary cholesterol and a decrease in energy value. Conclusion. This study indicates that an inadequate diet among both men and women represents a real health danger of developing atherosclerotic plaque.
9

Rethinking oxidized low-density lipoprotein, its role in atherogenesis and the immune responses associated with it

84%
Shaw P. X.
Archivum Immunologiae et Therapiae Experimentalis
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2004
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tom 52
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nr 4
10

New concept on the role of dietary fatty acids in atherogenesis

84%
Cybulska B., Szostak W. B.
Polish Journal of Food and Nutrition Sciences
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1998
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tom 07
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nr 2
11

Nonalcoholic fatty liver disease as a feature of the metabolic syndrome

84%
Socha P., Wierzbicka A., Neuhoff-Murawska J., Wlodarek D., Podlesny J., Socha J.
Roczniki Państwowego Zakładu Higieny
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2007
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tom 58
|
nr 1
The main features of the metabolic syndrome are obesity, insulin resistance and disturbed lipid metabolism. The same disturbances are regarded to be involved into the pathomechanism of nonalcoholic fatty liver disease which is shown by epidemiological studies and animal models. Thus NAFLD can be regarded a specific feature of the metabolic syndrome and it should be looked for in high risk populations.
12
Content available remote

Transcriptomic analysis of aorta from a short-term high-fat diet fed mouse reveals changes in the expression of vessel structure genes

67%
Dejeans N., Auclair S., Chauvet S., Milenkovic D., Mazur A.
Journal of Physiology and Pharmacology. Supplement
|
2009
|
tom 60
|
nr 1
37-45
High-density microarrays were recently used to identify the genomic profiles of vascular cells during atherogenesis. This strategy succeeded in identifying both biomarkers and underlying biological processes of the pathological development. However, data documenting the early stages of disease are sparse. To identify the mechanisms involved in atherogenesis, we examined differential gene expression in the aorta of C57BL/6J mice fed a high-fat diet (HFD) or a low-fat diet (LFD), for a short period of time of three weeks. The cDNA microarray analysis revealed that the expression of 448 genes was significantly different between the two groups. As expected, key genes involved in lipid synthesis or catabolism were down- and upregulated, respectively, representing a normal gene expression response to increased cellular lipid levels. Overrepresented biological processes were identified by Gene Ontology (GO) analysis, which revealed that aortic cells differentiate into a new phenotype in mice fed the HFD. This phenotype was represented by changes in the expression of 81 genes associated with extracellular matrix and cytoskeletal modifications. Some of these genes were previously shown to be involved in the cardiovascular diseases process. In conclusion, short-term HFD consumption results in metabolic disturbances leading to a broad induction of genes involved in vessel architecture remodelling.
13
Content available remote

The current view on the role of leukotrienes in atherogenesis

67%
Jawien J., Korbut R.
Journal of Physiology and Pharmacology
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2010
|
tom 61
|
nr 6
14
Content available remote

The effect of doxycycline on atherogenesis in apoE-knockout mice

67%
Pawlowska M., Gajda M., Pyka-Fosciak G., Toton-Zuranska J., Niepsuj A., Kus K., Bujak-Gizycka B., Suski M., Olszanecki R., Jawien J., Korbut R.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 2
Doxycycline at subantimicrobial doses inhibits matrix metalloproteinases (MMPs) activity, and is the only MMP inhibitor which is widely available in clinical practice. The aim of the study was to reveal whether non-specific MMPs inhibition by tetracycline could ameliorate development of atherosclerosis in apolipoprotein E (apoE)-knockout mice. Doxycycline (1.5 mg/ kg b.w./day) administered orally attenuated atherogenesis, measured both by "en face" method (10.25±1.7% vs. 15.7±2.0%, p<0.05) and "cross-section" method (66,254±7,468 µm2 vs. 90,687±8,521 µm2, p<0.05). In-situ zymography showed decrease of the extent of non-specific gelatinase activity in doxycycline-treated mice This is the first report to date describing the effect of doxycycline on atherogenesis in apoE-targeted mice.
15
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The effect of montelukast on atherogenesis in APOE-LDLR-double knockout mice

67%
Jawien J., Gajda M., Wolkow P., Zuranska J., Olszanecki R., Korbut R.
Journal of Physiology and Pharmacology
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2008
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tom 59
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nr 3
633-639
We have shown that inhibitors of five lipoxygenase activating protein (FLAP) - MK-886 and BAYx1005 inhibit atherosclerosis in apolipoprotein E / LDL receptor - double knockout mice. We, therefore, investigated whether cysteinyl leukotrienes receptor inhibitor - montelukast, given at a dose of 0.125 µg per 100 mg of body weight per day during 16 weeks, could also attenuate atherogenesis. In apoE/LDLR - DKO mouse model montelukast significantly decreased atherogenesis, measured both by "en face" method (25.5±2.% vs. 17.23 ± 1.8%) and "cross-section" method (455 494 ± 26 477 µm2 vs. 299 201 ± 20 373 µm2). The results were, however, less pronounced, comparing to FLAP inhibitors. This is the first report showing the effect of montelukast on atherogenesis in gene-targeted mice.
16
Content available remote

Angiotensin-(1-7) receptor Mas agonist ameliorates progress of atherosclerosis in apoE-knockout mice

67%
Jawien J., Toton-Zuranska J., Gajda M., Niepsuj A., Gebska A., Kus K., Suski M., Pyka-Fosciak G., Nowak B., Guzik T. J., Marcinkiewicz J., Olszanecki R., Korbut R.
Journal of Physiology and Pharmacology
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2012
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tom 63
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nr 1
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