Wyniki wyszukiwania

1

BCL2 and BAX mRNA concentration profile in fibrillary astrocytoma

100%

Mazurek U., Bierzynska-Macyszyn G., Gola J., Orchel J., Slowinski J., Wilczok T.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

2

Cytokines regulate plasminogen activation system in astrocytoma cells

86%

Kasza A., Koj A.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 1

We report here that human astrocytoma cell line U373-MG is able to express genes of the following components of plasminogen activation system:PAI-1,PN-1,u-PA and t-PA. Treatment of these cells with IL-1 ß results in accumulation of PAI-1,PN-1 and u-PA mRNAs,whereas t-PA mRNA remains unaffected.IFN preferentially enhances PN-1 and PAI-1,EGF enhances PAI-1,u-PA and t-PA expression.Simultaneous addition of anti-inflammatory cytokines IL-4,IL-13 and IL-10 has little effect on the tested components,except induction of u-PA mRNA wich was further enhanced by IL-4.We have confirmed interesting time-dependent regulation of plasminogen activation system by EGF/IFN .Cells stimulated with EGF/IFN show at first increased proteolytic activity but after 24 h inhibition of proteolysis with PAI-1 would prevail.To understand the co- operative effect of EGF and IFN in PAI-1 induction the kinetics of activation of STAT1 was studied.It was found that although EGF alone does not activate STAT1,the STAT1 binding activity in the cells treated with the mixture of EGF/IFN was considerably prolonged.Our results indicate the importance of inflammatory cytokines and EGF in gene regulation of plasminogen activation system in astrocytoma cells.

3

VCAM-1 expression on reactive and tumour astrocytes

72%

Kaluza J., Krupinski J., Kumar P., Kumar S., Wang J. M.

Folia Histochemica et Cytobiologica

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1994

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tom 32

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nr 1

4

Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue [anaplastic astrocytoma and glioblastoma multiforme]

72%

Kotonski B., Wilczek J., Madej J., Zarzycki A., Hutny J.

Acta Biochimica Polonica

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2001

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tom 48

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nr 4

An approximately threefold increase in glycogenolytic activity of the neutral a-1,4-glucosidase and a twofold increase in the same activity of the acid isoform have been found in extracts of anaplastic astrocytoma and glioblastoma multiforme tumors of brain tissue. "Maltase activity" of the respective enzymes increased by 60-80% in both kinds of tumor extracts. However a significant decrease in a-amylase and almost complete disappearance of phosphorylase activities have also been found in both kinds of tumors.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Folia Histochemica et Cytobiologica

1 Folia Histochemica et Cytobiologica. Supplement

1 Journal of Physiology and Pharmacology

1 Bierzynska-Macyszyn G.

1 Gola J.

1 Hutny J.

1 Kaluza J.

1 Kasza A.

1 Koj A.

1 Kotonski B.

1 Krupinski J.

1 Kumar P.

1 Kumar S.

1 Madej J.

1 Mazurek U.

1 Orchel J.

1 Slowinski J.

1 Wang J. M.

1 Wilczek J.

1 Wilczok T.

1 Zarzycki A.

1 2002

2 2001

1 1994

BCL2 and BAX mRNA concentration profile in fibrillary astrocytoma

Cytokines regulate plasminogen activation system in astrocytoma cells

VCAM-1 expression on reactive and tumour astrocytes

Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue [anaplastic astrocytoma and glioblastoma multiforme]