Wyniki wyszukiwania

1

Work related asthma in Finnish farmers and contribution of working conditions

100%

Hanhela R. A., Iivonen E. J.

Annals of Agricultural and Environmental Medicine

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1994

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tom 01

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nr 2

2

Asthma, toxic alveolitis and respiratory symptoms among 1005 young farmers and 412 non farming rurals

88%

Sigsgaard T., Hjort C., Omland O.

Annals of Agricultural and Environmental Medicine

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1994

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tom 01

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nr 2

3

Eosinophil - epithelial cell interaction augments cysteinyl leukotrienes synthesis

88%

Jawien J., Chlopicki S., Olszanecki R., Lorkowska B., Gryglewski R. J.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 1

Eosinophils accumulation in the airways and sustained eosinophil-derived cysteinyl leukotrienes production represent key elements of the inflammatory response seen in asthma.However,it is not known whether activated epithelial cells influence cysteinyl leukotrienes production by eosinophils from healthy valunteers.The aim of the present study was therefore to analyse the effects of interactions between non-atopic eosinophils and epithelial cells on cysteinyl leukotrienes production in vitro .We measured cysteinyl leukotrienes released by phorbol 12-myristate 13-acetate (PMA)–activated human eosinophils or epithelial cells (human bronchial epithelial cell line -BEAS-2B)cultured alone or together.While activated BEAS-2B cells barely formed leukotrienes (1.39 pg/ml ± 0.2))(n=32),activated eosinophils produced considerable amount of them (62.25 pg/ml ± 10.29))(n=32).Interestingly,when activated eosinophils and epithelial cells were co-incubated,production of cysteinyl leukotrienes increased substantially (571.1 pg/ml ± 80.9))(n=32).Thus,eosinophil-epithelial cell interactions,when occur,are associated with increased biosythesis of cysteinyl leukotrienes.

4

The overproduction of nitric oxide associated with neutrophilic predominance is relevant to airway mycotic infections in asthmatics undergoing prolonged glucocorticoid treatment

88%

Cembrzynska-Nowak M., Liebhart J., Bienkowska-Haba M., Liebhart E., Kulczak A., Siemieniec I., Dobek R., Dor A., Barg W., Panaszek B.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr 4

5

Airway remodeling in chronic obstructive pulmonary disease and asthma: the role of matrix metalloproteinase-9

75%

Grzela K., Litwiniuk M., Zagorska W., Grzela T.

Archivum Immunologiae et Therapiae Experimentalis

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2016

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tom 64

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nr 1

6

Bronchial hyper-responsiveness, subepithelial fibrosis, and transforming growth factor-beta1 expression in patients with long-standing and recently diagnosed asthma

75%

Tomkowicz A., Kraus-Filarska M., Bar J., Rabczynski J., Jelen M., Piesiak P., Fal A., Panaszek B.

Archivum Immunologiae et Therapiae Experimentalis

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2008

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tom 56

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nr 6

401-408

7

Effects of inhaled corticosteroids on cough in awake guinea pigs with experimental allergic rhinitis - the first experience

75%

Brozmanova M., Calkovsky V., Plevkova J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2004

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tom 55

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nr 3

23-30

Allergic rhinitis is a common cause of chronic cough. Topical corticosteroids are regarded as the most effective first-time treatment in allergic rhinitis. In this study we evaluated the cough sensitivity during the early and late allergic responses in guinea pigs with experimental allergic rhinitis. Another aim of the study was to follow up the effect of inhaled beclomethasone dipropionate on the cough in guinea pigs with allergic rhinitis. 31 guinea pigs were sensitized with ovalbumin (OA). Animals were intranasally challenged with OA (experiment) or saline (control) in 7-day intervals for 9 weeks. Cough was induced by inhalation of citric acid aerosols in gradually increasing concentrations for 30 s and was evaluated 1 h after the 8th nasal challenge (NCH) and 17 h after the 9th NCH. Cough was significantly increased only during an early allergic response, 1 h after repeated NCH [18 (14-23) vs. 8 (3-10); P<0.001]. Five experimental animals were inhaling aerosol of beclomethasone dipropionate seven days between the 8th and the 9th NCH and cough was evaluated 1 h after the 9th NCH. Inhaled corticosteroids significantly inhibited the enhanced allergic rhinitis related cough [4 (1-9) vs.19 (9-37) vs. 6 (3-9); P<0.05].

8

Eosinophilic airway inflammation in chronic obstructive pulmonary disease and asthma

75%

Gorska K., Krenke R., Korczynski P., Kosciuch J., Domagala-Kulawik J., Chazan R.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

261-270

9

Bond disorders of a patient with asthma: a case study

75%

Wilczynska-Kwiatek A.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

739-749

10

The effect of short-term and chronic glucocorticoid therapy on lymphocyte glucocorticoid receptor number in patients with asthma

75%

Grzanka A., Rogala B.

Archivum Immunologiae et Therapiae Experimentalis

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2003

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tom 51

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nr 5

11

Intracellular signalling pathways in IgE-dependent mast cell activation

75%

Kopec A., Panaszek B., Fal A. M.

Archivum Immunologiae et Therapiae Experimentalis

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2006

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tom 54

|

nr 6

12

Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin

75%

Choi S., Park H. S., Cheon M. S., Lee K.

Archivum Immunologiae et Therapiae Experimentalis

|

2005

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tom 53

|

nr 2

13

Multi-organ manifestation of hay fever

75%

Buczylko K. M.

Annals of Agricultural and Environmental Medicine

|

1996

|

tom 03

|

nr 2

14

The use of magnesium in bronchial asthma: a new approach to an old problem

75%

Kowal A., Panaszek B., Barg W., Obojski A.

Archivum Immunologiae et Therapiae Experimentalis

|

2007

|

tom 55

|

nr 1

15

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Prevalence of asthma and some respiratory symptoms in the years 1995 and 2001 in school children from rural regions of Poland

75%

Emeryk A., Chojna E., Bartkowiak-Emeryk M., Postepski J.

Annals of Agricultural and Environmental Medicine

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2004

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tom 11

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nr 1

The aim of our study was to estimate the prevalence of asthma and some respiratory symptoms and diseases in schoolchildren from rural regions of Poland in 2001 and to compare these data with previous estimations in 1995. Repeated cross-sectional epidemiological studies were performed among 594 primary schoolchildren in 1995 and 541 in 2001 using the same standardized questionnaire. Lifetime prevalence of "doctor's-diagnosed asthma" increased significantly from 3.4% in 1995 to 9.6% in 2001. This trend may be due to the real increase in the prevalence of asthma and also may be a result of better physician's diagnosis and/or better parents' health education. A substantial increase of asthma-related symptoms (post-exercise breathlessness, wheezing and dyspnoea) was also observed between these years (8.3-17.7%, 6.2-13.2% and 7.6-13.3%, respectively). These results suggest that asthma in Polish schoolchildren is still underdiagnosed.

16

Serum concentration of C-reactive protein is not a good marker of bronchial hyperresponsiveness

75%

Panaszek B., Liebhart E., Liebhart J., Pawlowicz R., Fal A. M.

Archivum Immunologiae et Therapiae Experimentalis

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2007

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tom 55

|

nr 5

17

Respiratory symptoms and peak expiratory flow rates among furniture-decoration students

75%

Arbak P., Bilgin C., Balbay O., Yesildal N., Annakkaya A. N., Ulger F.

Annals of Agricultural and Environmental Medicine

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2004

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tom 11

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nr 1

This study was designed to evaluate the effects of furniture production, mainly including fir tree (aberia mulleriana), on respiratory health of young workers and to compare the results with those obtained from previous studies. Sixty-four furniture-decoration students (57 males and 7 females) and 62 controls (54 male, 8 female) from different departments in the same school were included into the study. All participants were assessed with a questionnaire (concerning history of occupational exposure, work-related respiratory and other symptoms, smoking history, previous asthma history), full physical examination, spirometric evaluation and chest radiograph. Participants then performed serial monitoring of peak expiratory flow rates (PEFR) at work and away from work within a month. Mean age of students was 20.9 ± 3.7 years, 20.5 ± 2.6 years in controls. There was no difference between study and control groups with regard to age, gender, smoking status and previous asthma history. Reported cough (23.4% vs. 8.1%) and shortness of breath (18.8% vs. 6.5%) were significantly higher in furniture-decoration students than in controls (p = 0.016 and p = 0.034, respectively). Furniture-decoration students had higher conjunctivitis (34.4% vs. 9.7%, p = 0.001) and rhinitis (34.4% vs. 19.4%, p = 0.044) history when compared with controls. Both students and controls were normal in terms of respiratory examination. PEF recordings were performed for approximately one month. Diurnal variability greater than 20% was seen in 12/64 (18.7%) of students at work, whereas it was detected in 4/62 (6.4%) of controls (p = 0,034). When comparing for the presence of diurnal variability greater than 20% in weekends, no difference was found between groups (p = 0.457). In conclusion, early detection of work-related respiratory changes by serial monitoring of peak expiratory flows should save the workers from hazardous respiratory effects of the furniture production, especially in young population.

18

Occupational asthma diagnosis workers exposed to organic dust

75%

Sigsgaard T., Schlunssen V.

Annals of Agricultural and Environmental Medicine

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2004

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tom 11

|

nr 1

The clinical evaluation of newly developed asthma in an adult should always include consideration of his occupational environment, since an abundance of different exposures, which are known causes of asthma, occur in workplaces. Two types of occupational asthma (OA) are distinguished, by whether they appear after a latency period: 1) Immunological OA, characterised by a latency period, caused by high and low-molecular-weight agents, with or without an IgE mechanism 2) Non-immunological, i.e. irritant induced asthma. The first step of the clinical evaluation is to confirm a diagnosis of asthma. Second step is to find out if there is a temporo-spatial distribution of symptoms and lung function that are indicative of OA. Third step is to determine if the disease at hand is an IgE or a non-IgE mediated disease. Last step is a challenge test that can be either unspecific, in order to assess the responsiveness of the lung, or specific challenge test, especially for the non-IgE mediated OA. The depth of clinical evaluation may vary from a situation in which a classical history confirms the clinical symptoms in e.g. a baker with confirmed allergy towards well-known allergens and a characteristic pattern in serial measurements of lung function, to more elaborate investigations in a situation with no or unknown allergen. In the latter situation, a specific challenge test might be necessary in order to find the offending agent. Finally, challenge tests are important in order to distinguish a causal relation from unspecific hyperresponsiveness in persons with pre-existing asthma. In these situations, extended sick leave and challenge tests can be the only way to find the answer.

19

MicroRNAs: potential biomarkers and targets of therapy in allergic diseases?

63%

Specjalski K., Jassem E.

Archivum Immunologiae et Therapiae Experimentalis

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2019

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tom 67

|

nr 4

20

Concentration of endothelin in plasma and BAL fluid from asthmatic patients

63%

Gawlik R., Jastrzebski D., Ziora D., Jarzab J.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

103-110

The bronchoconstrictive peptide endothelin-1 (ET-1) has been demonstrated in the airway epithelial and endothelial cells. In this study we investigated the pathophysiological significance of endothelin-1 in asthma. We addressed the issue by assessing the concentration of ET-1 in plasma and bronchoalveolar lavage fluid (BALF) in patients with a different intensity of asthma. Twenty one asthmatic patients (11 men,10 women) and 6 healthy control subjects (C) were included in the study. Eleven asthmatic patients were classified as moderate persistent asthma (SA), all of them were atopic, and another 10 were mild persistent asthmatics (AA). Lung function tests were carried out in all patients investigated. The ET-1 concentration was determined by an ELISA method in plasma and BALF. We found that the SA patients haed the highest level of ET-1 (SA - 11.4 ±3.6 fmol/ml; AA - 7.1 ±2.7 fmol/ml; C - 5.6 ±1.8 fmol/ml) in BALF. The same concerned the ET-1 level in plasma (SA - 27.8 ±3.8 fmol/ml; AA - 18.1 ±4.3 fmol/ml; C - 17.3 ±3.0 fmol/ml). A positive correlation between the plasma ET-1 level and lung function indices was observed. We conclude that the higher levels of ET-1 in more severe asthma suggest that endothelins may contribute to the pathophysiology of the disease, its severity, and the regulation of bronchial tone.

Ograniczanie wyników

Work related asthma in Finnish farmers and contribution of working conditions

Asthma, toxic alveolitis and respiratory symptoms among 1005 young farmers and 412 non farming rurals

Eosinophil - epithelial cell interaction augments cysteinyl leukotrienes synthesis

The overproduction of nitric oxide associated with neutrophilic predominance is relevant to airway mycotic infections in asthmatics undergoing prolonged glucocorticoid treatment

Airway remodeling in chronic obstructive pulmonary disease and asthma: the role of matrix metalloproteinase-9

Bronchial hyper-responsiveness, subepithelial fibrosis, and transforming growth factor-beta1 expression in patients with long-standing and recently diagnosed asthma

Effects of inhaled corticosteroids on cough in awake guinea pigs with experimental allergic rhinitis - the first experience