Introduction. Lowlevels of high-density lipoprotein (HDL) cholesterol is a risk factor for coronary artery disease. Besides lifestyle, some gene polymorphisms areknown to be related to the individual HDL-cholesterol concentration. Aim. An apolipoprotein AI gene promoterpolymorphism, related to an adenine (A) to guanine (G) transition 75 base pairs upstream from the transcription initiation site, was studied in the group of healthy men. Methods. Genotyping was performed by polymerase chain reaction method with MspI restriction enzyme. Lipid profile was determined by routine biochemical measurements and apolipoprotein AI concentration was obtain by an immunotubidymetric method. Results. Frequency of the rare A allele was 16% and in the study group only one case of the AA genotype was found, whereas GG variants was observed in 23 participants (68%). Statistically significant differences were noted in HDL concentrations between A allele carriers and GG homozygotes: 56 ± 12 mg/dL vs 46 ± 12 mg/dL, respectively. GG males had also about 20 mg/dL lower apolipoprotein AI levels and about 17 mg/dL higher triglyceride levels. Conclusions. In the studied men of Polish origin the A allele was associated with higher HDL-cholesterol and apolipoprotein AI levels compared to GG homozygotes.
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