The aim of the research was to show the immunocytochemical expression of MT and Ki-67 and the correlation between these markers in spontaneous epithelium mammary gland cancer in bitches. The samples used in the research were extracted during surgical procedures from 20 bitches of different breeds, ranging from 6 to 15 years of age who had been diagnosed with mammary gland tumors. The prepared samples were then photographed with a microscope, to be later analyzed by a workstation comprised of a computer hooked up to a Carl Zeiss microscope model: Axiophot. The workstation was able to register images and then digitally analyze them. The MultiScaneBase V 8.08 program working on a Microsoft Windows platform was used to gather readings. The average correlation value between the Ki-67 and MT expression confirmed by many tests indicated a high index value of Ki-67 antigen as the prognostic agent. The study concluded that the presence of metalotionein in adenocarcinamas of the mammary gland in bitches does not indicate its connection with an increased proliferation potential of the cancer cells as is in the case in womens mammary gland tumors.
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