Wyniki wyszukiwania

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Assessment of the efficiency of applying methisoprinol and vaccination of turkeys against the haemorrhagic enteritis virus using in ovo methods

100%

Koncicki A., Tykalowski B., Stenzel T., Andrzejewski M.

Bulletin of the Veterinary Institute in Puławy

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2009

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tom 53

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nr 1

13-15

The aim of the research was to determine the efficiency of in ovo immunisation of turkeys against the haemorrhagic enteritis virus, while simultaneously applying a synthetic immunomodulator - methisoprinol - by the same route of administration. Dindoral SPF vaccine, in a dose of 0.1 ml of the solution prepared ex tempore after dissolving the vaccine in 100 ml of water for injection, and methisoprinol in a dose of 5 mg per egg, were administered in ovo on the 26th d of incubation. The control groups consisted of turkeys hatched from eggs into which only the methisoprinol or the vaccine was administered, as well as birds hatched from eggs that were not interfered with. The susceptibility of turkeys to HE virus infection was determined on the basis of the presence of HE antibodies in serum, the evaluation of a splenic index, and attempts to register the virus presence in the spleen 120 h after the control infections. The research proved the effectiveness of immunising turkeys against the haemorrhagic enteritis virus by administering Dindoral SPF vaccine in ovo. It was also demonstrated that the simultaneous application of methisoprinol, showing an antiviral effect, and the vaccine inhibited the development of post vaccinal immunity against this virus.

2

Synthesis and anti-HIV properties of novel 6-phenylselenenyl-5-propyluracils

100%

Miazga A., Felczak K., Siwecka M. A., Lipniacki A., Piasek A., Kulikowski T.

Acta Biochimica Polonica

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2007

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tom 54

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nr 4

863-868

Novel 6-phenylselenenyl-5-propyluracils were synthesized from 5-propyluracil with the use of regioselective synthesis to give 1-[(2-hydroxyethoxy)-methyl]-6-phenylselenenyl-5-propyluracil (6), 1-ethoxymethyl-6-phenylselenenyl-5-propyluracil (9) and 1-benzyloxymethyl-6-phenylselenenyl-5-propyluracil (10). Interaction of these compounds with recombinant HIV-1 reverse transcriptase (RT) was evaluated using a non-isotopic colorimetric method. Compounds 9 and 10 exerted potent HIV RT inhibition (IC500.06 and 0.05 μM respectively) while compound 6 showed moderate inhibition (IC50=3.5 μM). Potent anti-HIV-1 activity in MT-2 cells inoculated by a syncythia-in-ducing HIV-1 (cat #3 strain) laboratory isolate was exerted by compounds 9 and 10 (EC500.62 μM and 0.025 μM, respectively), while compound 6 showed only moderate activity (IC50=4.1 μM). In addition, compound 10 showed very good in vitro therapeutic index (TI > 2046), indicating that it is a potential anti-HIV/AIDS drug.

3

The effect of volatile oil from Chinese mugwort leaf on human demodecid mites in vitro

100%

Du J., Gao R., Zhao J.

Acta Parasitologica

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2021

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tom 66

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nr 2

4

Antiviral activity of 2-chloro-2'-deoxyadenosine [2-CdA]

100%

Zahorska R., Mazur N., Skierski J. S., Grieb P.

Archivum Immunologiae et Therapiae Experimentalis

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1996

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tom 44

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nr 2-3

5

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The influence of precursors and elicitor feeding on lignans accumulation in cultures of Taxus × media roots carrying a taxadiene synthase transgene

80%

Wencel A., Syklowska-Baranek K., Lysik K., Pietrosiuk A.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2015

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tom 96

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nr 1

6

Inhibition of human immunodeficiency virus type 1 replication by human interferons alpha, beta and gamma

80%

Yamamoto J. K., Kruzel M. L., Louie H., Georgiades J. A.

Archivum Immunologiae et Therapiae Experimentalis

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1993

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tom 41

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nr 3-4

7

Morphological and chemical evaluation of St.John's wort [Hypericum perforatum L.] populations from Lithuania

80%

Bagdonaite E., Zygmunt B., Radusiene J.

Herba Polonica

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2001

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tom 47

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nr 4

Przedstawiono wyniki testowania zmienności 27 populacji Hypericum perforatum występujących na terenie Litwy. Dotyczyły one 15 parametrów morfologicznych i wartości gospodarczej. Wyniki zostały poddane wielokierunkowej analizie statystycznej w celu oznaczenia ich zmienności między populacjami. Wyniki testu Scheffe pozwoliły wybrać spośród analizowanych populacji grupy podobne pod względem morfologicznym. Badania pokazały, że populacje istotnie różnią się w obrębie głównych cech. W badanych populacjach oznaczono zawartość ciał czynnych w kwiatach. Flawonoidy tj. rutynę, hyperozyd, kwercetynę i kemferol oraz hyperycynę i pseudohyperycynę oznaczono metodą HPLC. Metodą spektrofotometryczną oznaczono natomiast sumę wszystkich flawonoidów. Ilościowa zmienność substancji aktywnych w różnych populacjach pozwoliła na wyselekcjonowanie najlepszych roślin do uprawy i zachowania kolekcji polowej.

Ograniczanie wyników

Assessment of the efficiency of applying methisoprinol and vaccination of turkeys against the haemorrhagic enteritis virus using in ovo methods

Synthesis and anti-HIV properties of novel 6-phenylselenenyl-5-propyluracils

The effect of volatile oil from Chinese mugwort leaf on human demodecid mites in vitro

Antiviral activity of 2-chloro-2'-deoxyadenosine [2-CdA]

The influence of precursors and elicitor feeding on lignans accumulation in cultures of Taxus × media roots carrying a taxadiene synthase transgene

Inhibition of human immunodeficiency virus type 1 replication by human interferons alpha, beta and gamma

Morphological and chemical evaluation of St.John's wort [Hypericum perforatum L.] populations from Lithuania