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1

Recent avenues of chemoterapeutic research

100%
Echardt S.
Acta Biochimica Polonica
|
1996
|
tom 43
|
nr 2
2

The experimental and theoretical study of 6-thioguanine and their derivatives

100%
Rubin Y., Leszczynski J.
Cellular and Molecular Biology Letters
|
1999
|
tom 04
|
nr 3
3

The geometry of intercalation complex of antitumor mitoxantrone and ametantrone with DNA: Molecular dynamics simulations

86%
Mazerski J., Martelli S., Borowski E.
Acta Biochimica Polonica
|
1998
|
tom 45
|
nr 1
Intercalative binding of the antitumor drugs ametantrone and mitoxantrone to the dodecamer duplex d(CGCGAGCTCGCG)2 was studied by applying molecular dynamics in water with the GROMOS 87 force field. A number of reasonable binding orientations were tested by short pre-simulations. It was shown that in energetically favorable orientation the anthraquinone chromophore is perpendicular to the direction of inter-base hydrogen bonds. Helically shaped side-chains of the drugs fit to the minor groove. The best orientation obtained in pre-simulations was applied in the main simulations. Small but significant differences were found between structures of intercalation complexes of the two drugs with the dodecamer duplex, the mitoxantrone complex possessing more favorable energy. The molecular nature of interactions responsible for those differences has been discussed.
4

Synthetic analogues of netropsin and distamycin-synthesis of a new pyridine and carbocyclic analogues of the pyrrolecarboxamide antitumour antibiotics

86%
Bartulewicz D., Bielawski K., Markowska A., Zwierz K., Puckowska A., Rozanski A.
Acta Biochimica Polonica
|
1998
|
tom 45
|
nr 1
A new series of pyridine-containing analogues III-XXII of distamycin A and netropsin was investigated by the molecular mechanics technique and molecular modelling. A pyridine analogue of netropsin (VII) is described, the first compound based on molecular studies, and two carbocyclic analogues of distamycin A with an N-terminal chloro- or bromoacetyl group (VIa, VIIa) were synthesized, as well as carbocyclic analogues of netropsin (VIIIb, Xb), potential carriers of alkylating elements. The potential use of VIa, VII, VIIa, VIIIb and Xb as carriers to place into the minor groove of DNA chemical groups capable of modifying DNA, is discussed.
5

The effect of new anthracycline derivatives on the induction of apoptotic processes in human neoplastic cells

86%
Gruber B. M., Anuszewska E. L., Priebe W.
Folia Histochemica et Cytobiologica
|
2004
|
tom 42
|
nr 2
6

Transplantable mouse mammary adenocarcinoma 16/C as a model in experimental cancer therapy. III. Sensitivity to antitumor drugs

72%
Rak J., Kusnierczyk H., Strzadala L., Klosiewicz S., Radzikowski C.
Archivum Immunologiae et Therapiae Experimentalis
|
1989
|
tom 37
|
nr 3-4
7

Biological evaluation of mitoxantrone dihydrochloride synthesized by a new method. II. Comparison of Now 85/34 and novantrone (Lederle) acute toxicity and antitumor activity

72%
Matuszyk J., Kusnierczyk H., Radzikowski C.
Archivum Immunologiae et Therapiae Experimentalis
|
1989
|
tom 37
|
nr 1-2
8

Lack of squamous cell lung carcinoma in vitro chemosensitivity to various drug regimens in the adenosine triphosphate cell viability chemosensitivity assay

72%
Vogt U., Striehn E., Bosse U., Klinke F., Falkiewicz B.
Acta Biochimica Polonica
|
1999
|
tom 46
|
nr 2
A pilot study on squamous cell lung carcinoma (LC) chemosensitivity in adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA) was performed. Besides the histological investigation, a modified ATP-CVA was used for the analysis of cancer cell chemosensitivity to four drug regimens, including topotecan, a promising agent for non-small-cell lung cancer (NSCLC) chemotherapy. Results of in vitro chemosensitivity testing showed chemoresistance or only weak response in the predominant amount of tumors.
9

Molecular modeling of singlet-oxygen binding to anthraquinones in relation to the peroxidating activity of antitumor anthraquinone drugs

72%
Liwo A., Jeziorek D., Ossowski T., Dyl D., Tempczyk A., Tarasiuk J., Nowacka M., Borowski E., Woznicki W.
Acta Biochimica Polonica
|
1995
|
tom 42
|
nr 4
Anthraquinone derivatives are important anti-cancer drugs possessing, however, undesirable peroxidating and, in consequence, cardiotoxic properties. This results from the mediation by these compounds of the one-electron reduction processes of the oxygen molecule, which produces the highly toxic superoxide anion radical and other active oxygen species. This article summarizes the results of our studies on the molecular aspects of the mechanism of anthraquinone-mediated peroxidation which were carried out using enzymatic-assay, electrochemical, and quantum-mechanical methods.
10

Binding of SPXK- and APXK-peptide motifs to At-rich DNA. Experimental and theoretical studies

72%
Brzeski J., Grycuk T., Lipkowski A. W., Rudnicki W., Lesyng B., Jerzmanowski A.
Acta Biochimica Polonica
|
1998
|
tom 45
|
nr 1
The binding properties of the SPXK- and APXK-type peptides to the AT-rich DNA fragments of different length were studied by measuring the competition of peptides with Hoechst 33258 dye for DNA binding and by the gel shift assay analysis. In parallel to the experimental studies, molecular modeling techniques were used to analyze possible binding modes of the SPXZ and APXK motifs to the AT-rich DNA. The results of the competition measurements and gel shift assays suggest that serine at the i-1 position (i is proline) can be replaced by alanine without affecting the binding properties of the motif. Thus, the presence of the conserved serine in this motif in many DNA-binding proteins is probably not dictated by structural requirements. Based on the results of molecular modeling studies we propose that the binding mode of the SPXK- type motifs to the AT-rich DNA resembles closely that between the N-terminal arm of the homeodomain and DNA. This model confirms that serine in the SPXK motifs is not essential for the DNA binding. The model also indicates that if X in the motif is glutamic acid, this residue is probably protonated in the complex with DNA.
11

DNA-protection cross-linking induced by nitracrine in two strains of mouse lymphoma L5178Y cells

72%
Ciesielska E., Walicka M., Pastwa E., Szmigiero L.
Acta Biochimica Polonica
|
1992
|
tom 39
|
nr 1
12

Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay

72%
Vogt U., Falkiewicz B., Bielawski K., Bosse U., Schlotter C. M.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 1
A pilot study on relationships of selected molecular factors [erbB-1, erbB-2, erbB-3, and c-myc oncogene average gene copy numbers (AGCN); steroid receptors and pS2 gene expression; tumor cells' DNA values] to the ex vivo chemosensitivity of ovarian cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Despite the relatively small number of patients, numerous correlations among the factors tested were found. Nevertheless, only c-myc gene dosage positively affected ex vivo chemosensitivity of tumors tested.
13

Cis-DDP induced alteration of DNA structure studied by scanning tunneling microscopy

72%
Zastawny T. H., Olejniczak W., Olinski R.
Acta Biochimica Polonica
|
1993
|
tom 40
|
nr 4
Scanning tunneling microscopy (STM) was used to study the structural changes of DNA induced by the antitumor drug cts-diamminedichloroplatinum. The STM image showed a dramatic structural perturbation of the DNA by complexed Pt with the characteristic bend of the double helix.
14

Effect of structural modification at the 4,3', and 2' positions of doxorubicin on topoisomerase II poisoning, apoptosis, and cytotoxicity in human melanoma cells

72%
Gruber B. M., Anuszewska E. L., Bubko I., Gozdzik A., Fokt I., Priebe W.
Archivum Immunologiae et Therapiae Experimentalis
|
2007
|
tom 55
|
nr 3
15

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

58%
Zhang Y.-W., Shi J., Li Y.-J., Wei L.
Archivum Immunologiae et Therapiae Experimentalis
|
2009
|
tom 57
|
nr 6
435-445
16

Inhibitory effect of Greenland shark liver oil combined with squalen and Arctic birch ashes on angiogenesis and L-1 sarcoma growth in Balb/c mice

58%
Skopinska-Rozewska E., Chorostowska-Wynimko J., Krotkiewski M., Rogala E., Sommer E., Demkow U., Skurzak H.
Polish Journal of Veterinary Sciences
|
2003
|
tom 06
|
nr 3 Suppl.
17

Biological evaluation of mitoxantrone dihydrochloride synthesized by a new method. I. Acute toxicity and antitumor activity in mouse transplantable tumor systems

58%
Matuszyk J., Kusnierczyk H., Radzikowski C.
Archivum Immunologiae et Therapiae Experimentalis
|
1989
|
tom 37
|
nr 1-2
18

The effect of angiogenesis inhibitor TNP-470 on the blood vessels of the lungs, kidneys and livers of treated hamsters

58%
Mysliwski A., Kubasik-Juraniec J., Koszalka P., Szmit E.
Folia Morphologica
|
2004
|
tom 63
|
nr 1
The growth of solid tumours and their metastases is dependent on the development of new blood vessels (angiogenesis). Therefore angiogenesis inhibitors are potential antitumour drugs. In our previous studies it was found that the angiogenesis inhibitor TNP-470 given to transplantable melanoma-bearing hamsters can decrease the rate of the tumour growth, although the survival time of the animals treated was not significantly affected. It was found finally that TNP-470 given in the vicinity of the growing tumour can cause complete remission of the melanoma in hamsters treated in this way. To check what side-effects could be evoked by such treatment, an examination of the morphology of the blood vessels of the lungs, kidneys and livers of the treated animals was carried out. It was found that the angiogenesis inhibitor applied did not cause any changes which could be observed by light and electron microscopes in the structure of the examined blood vessels of the treated animals.
19

The ability of new formamidine sugar-modified derivatives of daunorubicin to stimulate free radical formation in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome p450 reductase and xanthine oxidase

58%
Pawlowska J., Tarasiuk J., Borowski E., Wasowska M., Oszczapowicz I., Wolf C. R.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 1
Some sterically hindered N-substituted derivatives of daunorubicin are known to be poor substrates for NADH dehydrogenase, NADPH cytochrome P450 reductase and xanthine oxidase. In consequence, poor oxygen radical generation by these compounds is observed. In this study we examined a new family of sugar-N-substituted derivatives of daunorubicin bearing a bulky substituent introduced on the nitrogen atom through the amidine spacer. These compounds were found to be very active in radical formation catalyzed by all three studied enzymes. Thus, the introduction of a heterocyclic ring, even if it is bulky but flexible, on the nitrogen atom of daunosamine moiety through the one-atom spacer (amidine group), does not induce the steric hindrance effect on the interaction of daunorubicin derivatives with these flavoprotein enzymes.
20

C-myc oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer

58%
Falkiewicz B., Schlotter C. M., Bosse U., Bielawski K., Vogt U.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 1
A pilot study on relationships of selected molecular factors (c-myc oncogene average gene copy numbers (AGCN); serum CEA and CA 15.3 antigen levels; tumor cells' DNA values), to the ex vivo chemosensitivity of primary female human breast cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Four drug combinations were tested. A group of 75 cases of female primary breast cancer was assessed. Numerous correlations were found among molecular factors tested but none, with the exception of tumor grading, of these reflected ex vivo chemosensitivity of tumors tested. The results suggest that the parameters tested may not be important factors related to adjuvant chemoresponsiveness of primary human breast cancer to tested drug combinations
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