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O możliwości wykorzystania morszczynu pęcherzykowatego (Fucus vesiculosus L.)

100%
Bulinski R., Artamonow E.
Roczniki Państwowego Zakładu Higieny
|
1957
|
tom 08
|
nr 1
2

Effect of Sphaeranthus indicus ethanol extract on tissue antioxidant activity in gentamicin induced nephrotoxic rats

100%
Mathew J. E., Mantri A., Vachala S. D., Srinivasan K. K., Movaliya V.
Herba Polonica
|
2009
|
tom 55
|
nr 4
86-95
The purpose of the present study is to investigate whether the alcoholic extract of Sphaeranthus indicus could decrease the intensity of toxicity in albino rats. Gentamicin at a dose of 80mg/kg body weight was administered intraperitonially to albino male Wistar rats for 8 days. Then another set of animals were given the alcoholic extracts of S. indicus along with gentamicin treatment. The antioxidant levels, serum creatinine, serum urea etc were analyzed. The extracts could significantly decrease the gentamicin induced nephrotoxicity as inferred from the tissue antioxidant status in the drug administered animals. Remarkable change was observed in serum creatinine and urea levels. Lipid peroxidation in the kidney and liver tissues was also considerably reduced in S. indicus extract treated animals. The nephrotoxic rats showed lower activities of superoxide dismutase, catalase, glutathione transferase and reduced glutathione content in the liver and kidney which were restored to normal levels by treatment with S. indicus extract. The increased levels of lipid peroxidation in nephrotoxic rats were reverted back to normal levels after the treatment with S. indicus ethanol extract. These results suggest that it has protective effect against gentamicin induced nephrotoxicity which may be attributed to its antioxidant potential.
3

Anti-inflammatory effect of some cucurbitaceous plants

100%
El-Gengaihi S., Abd El-Hamid S. R., Kamel A. M.
Herba Polonica
|
2009
|
tom 55
|
nr 4
119-126
The anti-inflammatory effect of three plants of Cucurbitaceae family: Ecballium elaterium, Cucumis prophetarum and Luffa cylindrica were studied using their petroleum ether and alcohol extracts. The recorded LD50 due to i.p. administration of petroleum ether of E. elaterium and L. cylindrica and alcohol of C.prophetarum, as representative extracts, were 3.4, 0.45 and 1.5 g/kg b.wt., respectively. The carrageenan induced edema in rats was significantly reduced by pre-treatment with petroleum ether extract of E. elaterium, C.prophetarum herbs and Luffa cylindrica fruits after 2h, while alcohol extract of E. elaterium herb caused a maximum inhibition of edema which amounted to 76.9% in comparison with the other extracts.
4

Effect of Willow herb [Epilobium angustifolium L.] extract on gene expression of selected P450 cytochromes in rat liver - preliminary study

88%
Kujawski R., Ozarowski M., Derebecka-Holysz N., Bartkowiak-Wieczorek J., Bogacz A., Karasiewicz M., Mikolajczak P. L., Bobkiewicz-Kozlowska T., Mrozikiewicz P. M.
Herba Polonica
|
2009
|
tom 55
|
nr 4
52-64
One of alternative strategies in prevention and therapy of Benign Prostatic Hyperplasia (BPH) is the usage of a number of traditional herbal plants. In recent years, there is an increasing interest in some members of the Epilobium genus in the treatment of BPH. So far there is no data about molecular mechanisms of action of Epilobium angustifolium L. extracts in liver. The aim of this study was to investigate the influence of the standardized water extract from the Epilobium angustifolium L. on expression level of selected P450 cytochromes encoding genes (CYP3A1 and CYP7A1) in rats liver tissues, which protein products are involved in steroids metabolism. The most abundant fraction of active compounds obtained from the extract was a phenolic fraction (24.36% m/m phenolic compounds and small amounts of flavonoglycosides – 0.91% and sterols – 0.09%). The plant extract showed the strongest and significant inhibitory CYP3A1/2 mRNA expression effect in rat liver. Our results suggest that a standardized E. angustifolium extract can regulate transcription level of investigated CYP genes in a different manner since a strong inhibition of CYP3A1 mRNA expression and slight induction of CYP7A1 may be a result of different extract action on the investigated CYP’s transcription machinery in rat liver cells.
5

Non-opioid peptides for analgesia

88%
Chrubasik J., Chrubasik S., Martin E.
Acta Neurobiologiae Experimentalis
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1993
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tom 53
|
nr 1
6

Antinociceptive and anti-inflammatory activities of Trigonella foenum-greacum seeds

75%
Laroubi A., Farouk L., Aboufatima R., Bensalah A., Zyad A., Benharref A., Bagri A., Chait A.
Herba Polonica
|
2009
|
tom 55
|
nr 4
105-118
Trigonella foenum-graecum L.(Leguminosae), known in Morocco as “Helba”, is used in folk medicine for its anti-ulcer, anti-inflammatory, cicatrizing activities and to treat various pain-related physiological states. In present study, we attempted to verify the possible antinociceptive and anti-inflammatory activities of different extracts obtained from the seeds of this plant. Three experimental models were used (i.e. acetic acid, formalin, and hot-plate tests) in order to characterize both the analgesic and the anti inflammatory effects. Dichloromethane (350 and 500 mg/kg), ethyl acetate [(EAE) (350 and 500 mg/kg)], aqueous (500 mg/kg) and butanolic (500 mg/kg) extracts significantly and in a dose-dependent manner reduced the pain induced by IP injection of acetic acid. In the formalin test, the extracts, except EAE, significantly reduced the painful stimulus but only in the early phase of the test. On the contrary, these extracts, except EAE, were ineffective in increasing the latency of licking or jumping in the hot-plate test. These results suggest that the compounds present in the extracts activated both central and peripheral mechanisms to elicit the analgesic and anti-inflammatory effects. However, pharmacological and chemical studies are continued in order to characterize these mechanisms and also to identify the active principles present in each extract.
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