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Anti-tumor chemotherapy utilizing peptide-based approaches - apoptotic pathways, kinases, and proteasome as targets

100%

Mendoza F. J., Espino P. S., Cann K. L., Bristow N., McCrea K., Los M.

Archivum Immunologiae et Therapiae Experimentalis

2005

tom 53

nr 1

Combined delivery of an antiangiogenic protein [angiostatin] and an immunomodulatory gene [interleukin-12] in the treatment of murine cancer

84%

Wilczynska U., Kucharska A., Szary J., Szala S.

Acta Biochimica Polonica

2001

tom 48

nr 4

We investigated the feasibility of a novel therapeutic approach to treat neoplastic diseases in mice. This novel strategy consists in delivering a protein (angiostatin) with strong antiangiogenic properties, followed by administration of the interleukin 12 gene that is strongly immunomodulatory and has also some antiangiogenic effects. When angiostatin-mediated antiangiogenic therapy was used in combination with intratumor delivery of the IL-12 gene (a strategy much safer than IL-12 protein administration), this produced a synergistic therapeutic effect.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Archivum Immunologiae et Therapiae Experimentalis

1 Bristow N.

1 Cann K. L.

1 Espino P. S.

1 Kucharska A.

1 Los M.

1 McCrea K.

1 Mendoza F. J.

1 Szala S.

1 Szary J.

1 Wilczynska U.

1 2005

1 2001

Wyniki wyszukiwania

Anti-tumor chemotherapy utilizing peptide-based approaches - apoptotic pathways, kinases, and proteasome as targets

Combined delivery of an antiangiogenic protein [angiostatin] and an immunomodulatory gene [interleukin-12] in the treatment of murine cancer