Wyniki wyszukiwania

1

Free radical scavengers can modulate the DNA-damaging action of alloxan

100%

Blasiak J., Sikora A., Czechowska A., Drzewoski J.

Acta Biochimica Polonica

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2003

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tom 50

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nr 1

Alloxan can generate diabetes in experimental animals and its action can be associated with the production of free radicals. It is therefore important to check how different substances often referred to as free radical scavengers may interact with alloxan, especially that some of these substance may show both pro- and antioxidant activities. Using the alkaline comet assay we showed that alloxan at concentrations 0.01-50 uM induced DNA damage in normal human lymphocytes in a dose-dependent manner. Treated cells were able to recover within a 120-min incubation. Vitamins C and E at 10 and 50 uM diminished the extent of DNA damage induced by 50 uM alloxan. Pre-treatment of the lymphocytes with a nitrone spin trap, a-(4-pyridil-1-oxide)- .-t-butylnitrone (POBN) or ebselen (2-phenyl-1,2-benzisoselenazol-3(2.H)-one), which mimics glutathione peroxides, reduced the alloxan-evoked DNA damage. The cells exposed to alloxan and treated with formamidopyrimidine-DNA glycosylase (Fpg) and 3-methyladenine-DNA glycosylase II (AlkA), enzymes recognizing oxidized and alkyl- ated bases, respectively, displayed greater extent of DNA damage than those not treated with these enzymes. The results confirmed that free radicals are involved in the formation of DNA lesions induced by alloxan. The results also suggest that alloxan can generate oxidized DNA bases with a preference for purines and contribute to their alkylation.

2

Repression of the Notch pathway prevents liver damage in streptozotocin-induced diabetic mice

80%

Acikgoz E., Aktug H., Yigitturk G., Demir K., Guven U., Duzagac F., Oltulu F., Yavasoglu A., Oktem G.

Folia Histochemica et Cytobiologica

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2017

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tom 55

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nr 3

3

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Alloxan stimulation and subsequent inhibition of insulin release from in situ perfused rat pancreas

80%

Kliber A., Szkudelski T., Chichlowska J.

Journal of Physiology and Pharmacology

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1996

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tom 47

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nr 2

4

A comparative study of some early effects after alloxan or streptozotocin treatment in rats

80%

Pruszynska E., Kaczmarek P., Fabis M.

Acta Scientiarum Polonorum. Medicina Veterinaria

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2002

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tom 01

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nr 1

5

May the free-radical-mediated alloxan cytotoxicity affect erythrocyte membranes? - A brief hypothesis

70%

Watala C., Jozwiak Z.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1992

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tom 40

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nr 1

6

A comparison of sciatic nerve neuropathy in diabetic and aged rats

70%

Koura N. H.

Folia Biologica

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2003

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tom 51

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nr 3-4

Ograniczanie wyników

Free radical scavengers can modulate the DNA-damaging action of alloxan

Repression of the Notch pathway prevents liver damage in streptozotocin-induced diabetic mice

Alloxan stimulation and subsequent inhibition of insulin release from in situ perfused rat pancreas

A comparative study of some early effects after alloxan or streptozotocin treatment in rats

May the free-radical-mediated alloxan cytotoxicity affect erythrocyte membranes? - A brief hypothesis

A comparison of sciatic nerve neuropathy in diabetic and aged rats