It was demonstrated that the process of hemolysis of erythrocytes induced by resorcinolic lipids is inhibited by divalent cations present in the incubation medium. The extent of inhibition is dependent on the nature of both type of the cation and the hemolytic agent. Lysis most susceptible to divalent cations is that induced by short (C15) and medium-chained (C19) 5-n-alkylresorcinols, which also have the highest observed hemolytic potencies. Furthermore, the protection was the stronger the stronger lytic activity was exerted by studied compound. The homologs with the longest side chain studied, although exhibiting the lowest hemolytic activity by themself, were the least susceptible to inhibition of their hemolytic activity by cations. The effect of cobalt cation has been found to be intermediate between the effect of Mn2+ and Zn2+. The most effective in protection of erythrocytes was Zn2+ which almost completely protected the cells against alkylresorcinol-induced lysis at the concentrations of 10-6 M and above.
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