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Stem cells and their outstanding concerns

100%

Lukomska B.

Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii

2012

nr 1

Stem cells have captured considerable scientific and clinic interest because of their potential to renew themselves and to differentiate into one or more adult cell types. Thus stem cells have been recognized as a potential tool for the development of innovative therapeutic strategies in different disease disorders. Stem cells can be discriminating based on their differentiated potential as totipotent, pluripotent, multipotent or unipotent cells. There are in general three types of stem cells: embryonic, fetal and adult stem cells. While embryonic stem cell therapy has a lot of ethical concerns due to their obtaining but also unlimited proliferation and uncontrolled differentiation, fetal and adult stem cells have been used in the treatment of different diseases. The bone marrow, peripheral blood and umbilical cord blood are ideal sources of adult stem cells because there are easily accessible and contain two types of stem cells: hematopoietic stem cells giving rise to all blood cell types and mesenchymal stem cells differentiating into cells of mesodermal lineage. This review describes the general characteristics of these stem cell populations and their current applications in regenerative medicine. Additionally induced pluripotent stem cells generated through the reprogramming of differentiated adult cells are described.

Human adipose-derived stem cells for the treatment of intracerebral hemorrhage in rats via femoral intravenous injection

80%

Yang K. L., Lee J. T., Pang C. J., Lee T. Y., Chen S. P., Liew H. K., Chen S. Y., Chen T. Y., Lin P. Y.

Cellular and Molecular Biology Letters

2012

tom 17

nr 3

Human adipose-derived stem cells (huADSC) were generated from fat tissue of a 65-year-old male donor. Flow cytometry and reverse transcription polymerase chain reaction (RT-PCR) analyses indicated that the huADSC express neural cell proteins (MAP2, GFAP, nestin and β-III tubulin), neurotrophic growth factors (BDNF and GDNF), and the chemotactic factor CXCR4 and its corresponding ligand CXCL12. In addition, huADSC expressed the characteristic mesenchymal stem cell (MSC) markers CD29, CD44, CD73, CD90, CD105 and HLA class I. The huADSC were employed, via a right femoral vein injection, to treat rats inflicted with experimental intracerebral hemorrhage (ICH). Behavioral measurement on the experimental animals, seven days after the huADSC therapy, showed a significant functional improvement in the rats with stem cell therapy in comparison with rats of the control group without the stem cell therapy. The injected huADSC were detectable in the brains of the huADSC treated rats as determined by histochemistry analysis, suggesting a role of the infused huADSC in facilitating functional recovery of the experimental animals with ICH induced stroke.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii

1 Chen S. P.

1 Chen S. Y.

1 Chen T. Y.

1 Lee J. T.

1 Lee T. Y.

1 Liew H. K.

1 Lin P. Y.

1 Lukomska B.

1 Pang C. J.

1 Yang K. L.

2 2012

Wyniki wyszukiwania

Stem cells and their outstanding concerns

Human adipose-derived stem cells for the treatment of intracerebral hemorrhage in rats via femoral intravenous injection