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Therapeutical effect of modified adamantane copolymer compounds: Study of molecular mechanisms

100%

Rybalko S., Nesterova N., Diadiun S., Danylenko G., Danylenko V., Guzhova S., Maksimov Y., Arkadiev V., Ivans'ka N., Maksymenok O., Vrnycianu N., Zhtrebtsova E., Grygoreva T.

Acta Biochimica Polonica

2001

tom 48

nr 1

Copolymers of N-polyvinylpyrrolidone-acrylic acid (AB-1) and adamantane derivatives are known to possess marked antiviral activity in in vitro and in ovo models. Among the constructed preparations of AB-1 modified by adamantane derivatives some, especially AB-4 (modified by deitiforin), were found to show more extended antiviral activity and to inhibit markedly virus reproduction in susceptible permissive cell cultures and chicken embryos. In AB-4 treated cells and allantoic sacs, virus titers (influenza virus, herpes virus, and HIV) and virus antigen concentration were decreased. On the other hand, herpes virus-specific thymidine kinase and of DNA-polymerases isolated from Escherichia coli, Plectonema boryanum, and herpes virus type 1 infected murine brain tissue retained their activity after incubation with AB-4 or AB-2. The compounds investigated, in view of their effect on virus reproduction, are thought to be prospective as antiviral agents.

Synthesis and antimicrobial activity of new adamantane derivatives I

80%

Orzeszko A., Gralewska R., Starosciak B. J., Kazimierczuk Z.

Acta Biochimica Polonica

2000

tom 47

nr 1

A series of fourteen derivatives of adamantane was synthesised. The new compound 4-(adamant-1-ylmethoxycarbonyl)phthalanhydride obtained from 1-adamantane- methanol and trimellitic anhydride chloride appeared very useful for preparation of a number of N-substituted phthalimides. Antimicrobial activity of the newly obtained derivatives such as, for example, 4-(adamant-1-ylmethoxycarbonyl)-N-(5-carboxypentamethylene)phthalimide or 4-(adamant-1-ylmethoxycarbonyl)-N-(L-alanyl)phthalimide was tested against Staphylococcus aureus, Bacillus sp., Micrococcus flavus and Enterococcus faecium. The minimal inhibitory concentration (MIC) for these compounds against S. aureus were 0.022 and 0.05 µg/ml, respectively.

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Arkadiev V.

1 Danylenko G.

1 Danylenko V.

1 Diadiun S.

1 Gralewska R.

1 Grygoreva T.

1 Guzhova S.

1 Ivans'ka N.

1 Kazimierczuk Z.

1 Maksimov Y.

1 Maksymenok O.

1 Nesterova N.

1 Orzeszko A.

1 Rybalko S.

1 Starosciak B. J.

1 Vrnycianu N.

1 Zhtrebtsova E.

1 2001

1 2000

Wyniki wyszukiwania

Therapeutical effect of modified adamantane copolymer compounds: Study of molecular mechanisms

Synthesis and antimicrobial activity of new adamantane derivatives I