Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 20

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  Trichophyton mentagrophytes
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
Immunogenicity of six strains of Trichophyton mentagrophytes var. granulosum isolated from arctic foxes with ringworm was evaluated in guinea pigs and foxes. Two strains of T. mentagrophytes (Tm-3 and Tm-4) out of six examined (Tm- 1, Tm-2, Tm-3, Tm-4, Tm-5 and Tm-6) induced in the experimental foxes a strong cellular immune response measured by the leukocyte migration inhibition test (LMIT), lymphocyte transformation test (LTT), and by skin delayed-type hypersensitivity (DTH). The guinea pigs immunised with Tm-3 and Tm-4 were well protected against the artificial infection with the virulent strain of T. mentagrophytes (Tm-9). These two strains of T. mentagrophytes with high immunogenic properties were used for production of a vaccine against ringworm in foxes.
The aim of the research was to investigate the possibility of using oral medicines for the treatment of animals with skin mycoses. The administration of oral azole antifungal Itraconazole was conducted on guinea pigs. In the light microscopy investigation during treatment of guinea pigs with Itraconazole, mycelium were not observed 4 days after the time of the administration of the drug, both in the stratum corneum of the epidermis and in hair sheaths. Neither was mycelium confirmed in the subcutaneous layer. Only parakeratose, hyperkeratose was observed, as well as a small degree of akantose. The investigation with the use scanning microscope made it possible to additionally affirm the presence on the top of scraps of spherical forms the accumulations of drops of fat which is characteristic for azole antifungals. The administration of oral azole antifungal causes the rapid regression of pathological changes in the deep layers of the skin. Therapy of this type can be useful in veterinary medicine.
Dermatophytes have the ability to invade keratinized tissue (hair, nails and skin). The invasion elicits a host response ranging from mild to severe. Local anti-dermatophyte immunity includes activation of macrophages, sensitization of T lymphocytes and the production of antibodies. Dermatophytes are eliminated from the skin by a cell-mediated immune reaction. Although antibodies play a small part in dealing with dermatophytosis, they somehow support fagocytosis and suppress adhesion of the fungus to host cells. The development of cell-mediated immunity correlated with delayed hypersensitivity is associated with clinical cure. Dermatophytoses are considered as an important epidemiological problem. Therefore, all the latest efforts to develop an effective vaccine against ringworm are significant. However, the immunology of the dermatophyte infection still remains to be comprehensively examined.
The study aimed at assessing effect of dried root and aerial parts of Medicago spp. on growth of Trichophtyton mentagrophytes. Fungus strains were inoculated onto microcultures with Sabouraud agar supplemented each with l g of dried and pulverised roots or aerial parts of 3 species: Medicago arabica, M. sativa, and M. murex. The strongest inhibitory effect on T. mentagrophytes growth was that of aerial parts of M. arabica (median diameter 6 mm compared to 13 mm of control), followed by root of M. arabica (10 mm) and root of M. murex (10.5 mm) - in all cases p < 0.001. Slight inhibitory effect was also found in the case of aerial parts of M. murex (median diameter 12 mm, p = 0.03). In contrast, M. sativa has shown stimulating effect on growth of T. mentagrophytes (15 mm for root and 16.5 mm for aerial part, p < 0.001).
The synthesis and antimicrobial activity of 31 morpholinium chlorides, divided into five series depending on the substituents attached to the nitrogen atom, N-carboxyalkyl-morpholinium chlorides (la-e), N-carbalkoxymethyl-N-methyl-morpholinium chlorides (2a-f), N-carbethoxymethyl-N-alkyl-morpholinium chlorides (3a-g), N-carbalkoxymethyl-N-dodecyl-morpholinium chlorides (4a-f) and N-car-boxymethyl-N-alkyl-morpholinium chlorides (5a-g) is reported. The compounds investigated were tested for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Candida albicans and Trichophyton menthagwphytes. The most active are compounds with a long N-alkyl group and with the substituent CH2COOCnH2n-1 (n = 8-16).
Dermatophytic infection is a common infection that constitutes public health problem among children. Anti dermatophytic activity of aqueous, ethanolic and methanolic extracts of garlic (Allium sativum) was investigated against isolates of dermatophytic fungi obtained from sixty primary school children in Aba. The well in agar diffusion technique was used to determine the sensitivity patterns of the test organisms. The results were compared with the activity of a known antifungal drug nystatin. The isolates included Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum gypseum, Trichophyton verrucosum and Epidermophyton floccosum. The result of the antifungal activity of garlic showed high but varied levels of antifungal effectiveness on the different species of the dermatophytes at four different concentrations of 12.5 %, 25 %, 50 % and 100 % used. T. rubrum was the most susceptible followed by M. gypseum, T. mentagrophytes, T. verrucosum and E. floccosum respectivey. The diameter zones of inhibition exhibited by the extracts against test fungal species ranged between 4.50 mm and 30.67 mm. Further purification and extraction of active principle of garlic would give an antidermatophytic activity comparable to standard antifungal drugs.
The aim of the study was to evaluate the CD3, CD4, CD8, CD19, CD25 T lymphocyte subpopulations and the state of granulocytes activity in the peripheral blood of rabbits infected with Trichophyton mentagrophytes and immunized against trichophytosis by using the flow cytometry method. Our study revealed significant suppression of non-specific cellular antimycotic immunity in rabbits during the development of fungal lesions, which manifested a significant decrease in the phagocytic activity and oxygen metabolism of granulocytes and the decrease of CD3, CD4 subpopulations and CD25 T lymphocytes. Simultaneously, the increase of suppressor CD8 T cells and CD4/CD8 T-cells ratio were observed. The vaccine Alopevac can be used as an effective vaccine against rabbit trichophytosis. Alopevac restored non-specific cellular antimycotic immunity and proper CD4/CD8 T-cells ratio, which contributed to the effective elimination of fungal lesions.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.