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RNA modulation, repair and remodeling by splice switching oligonucleotides

100%

Kole R., Williams T., Cohen L.

Acta Biochimica Polonica

2004

tom 51

nr 2

Targeting splicing by antisense oligonucleotides allows RNA modifications that are not possible with RNA interference or other antisense techniques that destine the RNA for destruction. By changing the ratio of naturally occurring splice variants the expression of mRNA is modulated. By preventing the use of an aberrant splice site created by a mutation and enforcing re-selection of correct splice sites the RNA is repaired. Antisense induced skipping of the exon that carries a nonsense mutation remodels the mRNA and restores the reading frame of the defective protein. All of the above approaches have clinical applications. Modulation of splice variants is particularly important since close to 60% of all genes code for alternatively spliced pre-mRNA.

RNA binding proteins in prokaryotes

51%

Wolska K. I.

Acta Microbiologica Polonica

1994

tom 43

nr 1

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Acta Microbiologica Polonica

1 Cohen L.

1 Kole R.

1 Williams T.

1 Wolska K. I.

1 2004

1 1994

Wyniki wyszukiwania

RNA modulation, repair and remodeling by splice switching oligonucleotides

RNA binding proteins in prokaryotes