Wyniki wyszukiwania

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The effect of insertion/deletion polymorphisms within the promoter and intron 1 sequences of the PRNP gene on the breeding value of Holstein-Friesian bulls

100%

Czarnik U., Strychalski J., Olenski K., Barcewicz M., Hering D. M., Puckowska P., Pierzchala M., Urbanski P., Pareek C. S.

Animal Science Papers and Reports

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2015

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tom 33

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nr 1

The aim of this study was to verify the hypothesis that insertion/deletion (indel) polymorphisms within the promoter and intron 1 sequences of the prion protein (PRNP) gene can affect the breeding value of Holstein-Friesian bulls. The experimental material included 261 Holstein-Friesian bulls born between 1997 – 2002. It was shown that the polymorphism in the intron 1 (12 bp indel) sequence had a more significant effect on the analyzed traits than a polymorphism in the promotor (23 bp indel) sequence. A deletion allele within intron 1 (12del) significantly increased the bulls’ breeding value for milk yield (p=0.001), protein yield (p=0.042), type and conformation (p=0.018),udder width (p=0.003), dairy character (p=0.004), and decreased days open (p=0.022). A deletion allele (23del) at the polymorphic locus of the promoter significantly decreased the bulls’ breeding value for milk yield (p=0.001), udder width (p=0.029) and dairy character (p=0.033). Analysis of both alleles showed that 23del-12del haplotype increased the bulls’ breeding value for udder traits:udder (p=0.008), fore udder (p=0.043) and udder depth (p=0.041), and decreased for fat kontent (p=0.047) and conformation traits - body depth (p<0.001), chest width (p=0.029) and rear leg set - side view (p=0.029). Also positive effect of 23del-12ins haplotype for days open (p=0.003) and days between calving and first insemination (p=0.045) was observed.

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Polymorphism in the PRNP locus in prolific Olkuska sheep

100%

Kaczor U., Domon D., Martyniuk E., Murawski M.

Bulletin of the Veterinary Institute in Puławy

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2011

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tom 55

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nr 1

PCR-RFLP method was used to identify polymorphisms in the 136 (A/V), 154 (R/H), and 171 (R/H/Q) codons of the prion protein gene (PRNP) in 174 ewes and rams of the prolific Olkuska sheep breed from three nucleus flocks. Alanine (A) at codon 136, arginine (R) at codon 154, and arginine (R) or glutaminę (Q) at codon 171, responsible for the presence of two alleles (ARR and ARQ) and three genotypes, (ARR/ARR, ARR/ARQ and ARQ/ARQ) were found in the analysed population. In all flocks, ARR allele (the most resistant to scrapie) was the dominant haplotype regardless of sheep sex, and ARR/ARQ genotype had the highest frequency (60.92%). The proportion of the undesirable ARQ/ARQ genotype was only 4.02%. Simulation of genotype distribution for the next generations showed that the mating of ewes with ARR/ARR genotype rams will cause this genotype to appear in 99% of Olkuska ewes already in the sixth generation. However, the study showed no relationship between genotype in the PRPN locus and prolificacy potential of the ewes.

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The polymorphism of MSTN, PRNP and CSN3 genes in Charolais cattle

100%

Dvorak J., Filistowicz A., Hruska D., Horal P., Vrtkova I., Kubek A., Szulc T., Pomichal S.

Animal Science Papers and Reports. Supplement

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2002

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tom 20

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nr 1

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Codon 129 polymorphism of the PRNP gene in normal Polish population and in Creutzfeldt-Jakob disease, and the search for new mutations in PRNP gene

100%

Bratosiewicz J., Liberski P. P., Kulczycki J., Kordek R.

Acta Neurobiologiae Experimentalis

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2001

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tom 61

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nr 3

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The reference gene selection to study PRNP gene expression in sheep

80%

Piestrzynska-Kajtoch A., Smolucha G., Oczkowicz M., Kycko A., Polak M. P., Kazaczynski W., Kozubska-Sobocinska A., Zmudzinski J. F., Rejduch B.

Folia Biologica

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2017

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tom 65

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nr 3

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Detection of lethal effects linked with the PRNP locus

80%

Walawski K., Wojciechowski R., Czarnik U., Zabolewicz T., Pareek C. S.

Bulletin of the Veterinary Institute in Puławy

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2006

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tom 50

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nr 1

7

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Frequencies of alleles and genotypes of the PRNP gene in Polish Red, Czech Pied and Czech Black-and-White cattle

80%

Vrtkova I., Filistowicz A., Dvorak A., Wierzbicki H., Szulc T.

Journal of Applied Genetics

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2001

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tom 42

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nr 4

Ograniczanie wyników

The effect of insertion/deletion polymorphisms within the promoter and intron 1 sequences of the PRNP gene on the breeding value of Holstein-Friesian bulls

Polymorphism in the PRNP locus in prolific Olkuska sheep

The polymorphism of MSTN, PRNP and CSN3 genes in Charolais cattle

Codon 129 polymorphism of the PRNP gene in normal Polish population and in Creutzfeldt-Jakob disease, and the search for new mutations in PRNP gene

The reference gene selection to study PRNP gene expression in sheep

Detection of lethal effects linked with the PRNP locus

Frequencies of alleles and genotypes of the PRNP gene in Polish Red, Czech Pied and Czech Black-and-White cattle