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PDZ domains - common players in the cell signalling

100%

Jelen F., Oleksy A., Smietana K., Otlewski J.

Acta Biochimica Polonica

2003

tom 50

nr 4

PDZ domains are ubiquitous protein interaction modules that play a key role in cellular signaling. Their binding specificity involves recognition of the carboxyl-termi- nus of various proteins, often belonging to receptor and ion channel families. PDZ domains also mediate more complicated molecular networks through PDZ-PDZ interactions, recognition of internal protein sequences or phosphatidylinositol moieties. The domains often form a tandem of multiple copies, but equally often such tandems or single PDZ domain occur in combination with other signaling domains (for example SH3, DH/PH, GUK, LIM, CaMK). Common occurrence of PDZ domains in Metazoans strongly suggests that their evolutionary appearance results from the complication of signaling mechanisms in multicellular organisms. Here, we focus on their structure, specificity and role in signaling pathways.

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AtDeg2 - a chloroplast protein with dual protease/chaperone activity

75%

Jagodzik P., Adamiec M., Jackowski G.

Acta Societatis Botanicorum Poloniae

2014

tom 83

nr 3

Chloroplast protease AtDeg2 (an ATP-independent serine endopeptidase) is cytosolically synthesized as a precursor, which is imported into the chloroplast stroma and deprived of its transit peptide. Then the mature protein undergoes routing to its functional location at the stromal side of thylakoid membrane. In its linear structure AtDeg2 molecule contains the protease domain with catalytic triad (HDS) and two PDZ domains (PDZ1 and PDZ2). In vivo AtDeg2 most probably exists as a supposedly inactive haxamer, which may change its oligomeric stage to form active 12-mer, or 24-mer. AtDeg2 has recently been demonstrated to exhibit dual protease/chaperone function. This review is focused on the current awareness with regard to AtDeg2 structure and functional significance.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Acta Societatis Botanicorum Poloniae

1 Adamiec M.

1 Jackowski G.

1 Jagodzik P.

1 Jelen F.

1 Oleksy A.

1 Otlewski J.

1 Smietana K.

1 2014

1 2003

Wyniki wyszukiwania

PDZ domains - common players in the cell signalling

AtDeg2 - a chloroplast protein with dual protease/chaperone activity