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1

The course of the glucose tolerance curve in rats infected with Nippostrongylus brasiliensis

100%
Stpiczynska R.
Acta Parasitologica
|
1992
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tom 37
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nr 1
The effect of Nippostrongylus brasiliensis infection (3000 larvae) on the course of the glucose tolerance curve in rats was investigated. On the 4th and 9th day after infection (DAI) rats displayed severe fasting hypoglycemia. Following oral glucose administration after 30 min this sugar appeared in blood of all rats: controls and infected ones (4 and 9 DAI) at a similar rate; however, the glucose tolerance curves of the infected rats, in contrast to controls, failed to reach maximal values after 30 min from the time of oral glucose administration. The infected and control rats exhibited an approximately similar blood glucose concentration only after 150 min from this administration. The results presented indicate that in rats infected with N. brasiliensis the glucose requirement is increased; malabsorption exerts no effext on the course of the glucose tolerance curves, and glucose deficiencies are compensated only after a lapse of a sufficiently long period (150 min) after glucose administration.
2
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Wpływ ołowiu na inwazyjność i rozrodczość nicienia Nippostrongylus brasiliensis (Travassos, 1914)

75%
Gadomska K.
Wiadomości Parazytologiczne
|
1991
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tom 37
|
nr 4
Influence of the lead on the biology of Nippostrongylus brasiliensis was examined. N. brasiliensis larvae exposed to the action of 200 ppm lead during 9 days were used to infect rats. The first group of the rats were infected with 1000 larvae kept in the solution of PBS whereas the larvae contaminated with the lead were given to the second group of rats. Capability to invasion of the contaminated larvae decreased by 28.7-57,2%. Reproductiveness of the N. brasiliensis decreased by 40.6% and the maximum point of production of the eggs was moved back by one day.
3
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Adaptacje Nippostrongylus brasiliensis [Travassos, 1914] do skazenia olowiem

75%
Gadomska K.
Wiadomości Parazytologiczne
|
1994
|
tom 40
|
nr 1
53-58
It was investigated whether toxicity of lead (Pb) is so high that its effect on Nippostrongylus brasiliensis larvae could be transferred into subsequent (3) generations of the nematode. Wistar rats were infected with a dose 1000 N. brasiliensis larvae contaminated with Pb (9 days at 200 ppm in solution). The number of larvae in lungs after 24 and 42 hours and the number of adult nematodes in the small intestine after 90, 114 and 236 hours after infection were examined. To determine reproductiveness of the N. brasiliensis the number of eggs was determined. Eggs of the first generation subjected to Pb (P generation) were used to culture a subsequent generation of invasive larvae (F₁) which were used to infect rats. Eggs from that generation were used to culture the next invasive larvae generation (F₂) used again to infect rats. Lungs dissection after 24 hours has shown that the P generation produced 12 times less larvae than the control, while generations F₁ and F₂ produced 4,9-5 times less larvae than the control. Dissection data for the small intestine show the highest loss in invasive capability of this nematode in generation F₁. The dynamics of eggs excretion is the lowest in F₁ and excretion period is shorter by 1 day. In F₂, the number of eggs excreted is 5.8 times higher than in the control group. It seems that in F₂ generation mechanisms enabling the species to survive under unfavorable environmental conditions were started.
4

Effect of Ivermectin on the course of Nippostrongylus brasiliensis infection in rats

75%
Doligalska M., Bezubik B.
Acta Parasitologica
|
1995
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tom 40
|
nr 3
The effect of Ivermectin on the number of cells and the percentage of IgA⁺ cells in bronchial (BLN) and mesenteric (MLN) lymph nodes of rats infected with 3000 L3 of Nippostrongylus brasiliensis was examined. Rats were treated subcutaneously with a dose of 100 pg/kg, 24 h after infection. After treatment, the worm burden was reduced by 90.7% in the parenteral phase and by 98.4% in the enteral phase of the infection. The respiratory tract was still occupied by the fourth stage larvae on day 6 after infection (AI). Adult worms were present in the intestine on day 18 AI while in untreated rats the infection was over already on day 13. No susceptibility to Ivermectin was found in some L4 stage of N. brasiliensis. Larvae trapped in the lungs stimulated very high level of cellular infiltration and IgA⁺ cell proliferation in the BLN. A weak enteral phase, which occurred after treatment with Ivermectin, induced a weak IgA response in the MLN. A temporary effect of Ivermectin which reduced the number of cells in MLN and no effect on the percentage of IgA⁺ cells in the BLN and MLN, were observed.
5
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Metody hodowli pasożytniczych nicieni in vitro

63%
Jablonowski Z., Piechocki D.
Wiadomości Parazytologiczne
|
1988
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tom 34
|
nr 2
The review of literature referring to cultivating methods of some parasitic nematodes in vitro is presented (Ascaridia galli, Ascaris suum, Nippostrongylus brasiliensis, Strongyloides fülleborni). It refers general problems and initiate in subject of parasites cultivating in vitro. This work comprises terminology and elementary problems connected with the starting of culture of parasites in vitro, such as: obtaining of parasites to the starting of cultures, the types of cultures in vitro and forming of conditions to determine successful of culture of parasitic nematodes in vitro (sterilization, the selecting of medium, the forming of most favourable physical-chemical conditions).
6
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Effect of zinc on invasive capacity and reproduction of Nippostrongylus brasiliensis [Nematoda] in rats

63%
Gadomska K.
Wiadomości Parazytologiczne
|
1996
|
tom 42
|
nr 4
7

Vaccination of rats against the rodent hookworm Nippostrongylus brasiliensis with a recombinant superoxide dismutase fails to protect against infection

51%
Ball G., Knox D. P.
Acta Parasitologica
|
2009
|
tom 54
|
nr 3
281-287
Anti-oxidant enzymes including superoxide dismutase (SOD) protect cells from damage by oxygen radicals produced during respiration. There is also a substantial body of evidence that anti-oxidant enzymes facilitate the survival of parasitic helminths, including gastrointestinal nematodes, within the host. Superoxide dismutase has been shown to be released by a variety of parasitic helminths and may protect them from host mediated oxidative immune responses. As it may play a parasite protective role during infections SOD has been investigated as a vaccine candidate in a range of helminth parasites including Schistosoma mansoni, Acanthocheilonema viteae and Haemonchus contortus. Here, we sought to evaluate the protective potential of SOD against the rat hookworm Nippostrongylus brasiliensis, a commonly utilised laboratory infection, as a vaccination model. A cytosolic SOD from this parasite, with high sequence homology to a putative extracellular form of the enzyme was cloned and then expressed in bacteria. The resultant recombinant protein was assessed for enzyme activity and used to immunise rats prior to a single challenge infection with the parasite. No protection was observed and monitoring systemic and mucosal antibody responses and mast cell protease levels in superoxide dismutase vaccinated rats suggested that this recombinant SOD was only weakly immunogenic.
8
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Survival of larvae of Nippostrongylus brasiliensis [Nematoda] in solutions of toxic substances

51%
Gadomska K., Zakrzewska K.
Wiadomości Parazytologiczne
|
1997
|
tom 43
|
nr 1
The aim of this study was to determine the action of zinc, cooper, lead and cadmium compounds upon N. brasiliensis invasive nematode larvae. The tested larvae were kept in ZnCl2, CuCl2 , Pb(NO3)2 and CdCl2 solutions. The concentrations of toxic substances applied for the study corresponded with level of environmental pollulion. All toxins reduced live - space of larvae. In control group they survived about 69 days. In solutions of the Zn, contaminated with 10, 50, 100 and 200 ppm of toxic substance, they survived 42, 16, 14 days and 72 hours. In solution of Cu, contaminated with 5, 10, 50 and 200 ppm of toxin, live - space was reduced to 51, 21, 7 days and 54 hours, respectively. Lead reduced live - space of larvae to 26 days already at the low concentration of 10 ppm and in all higher concentrations (20, 50 and 200 ppm) their survival changed unsignificantly (to 22 days). In solution of Cd, contaminated with 0.1 and 0.3 ppm larvae died after 39 and 17 days, respectively, white at higher concentrations of this toxin (3 and 10 ppm) larvae survived only 54 and 30 hours, respectively.
9

Biological adaptation of the generations of Nippostrongylus brasiliensis nematode to the lead polluted environment

45%
Gadomska K.
Bulletin of the Polish Academy of Sciences. Biological Sciences
|
1993
|
tom 41
|
nr 3
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